Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VAX2
  • Mouse genes Vax2
  • Rat genes Vax2
  • Zfish genes vax2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vax2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031490	chromatin DNA binding	Vax2	IDA		Mouse	PMID:15905411
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Vax2	IDA		Mouse	MGI:MGI:3578573|PMID:15905411
Molecular Function	GO:0005515	protein binding	VAX2	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAX2	IPI	UniProtKB:Q6NVU6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAX2	IPI	UniProtKB:Q99471	Human	PMID:32296183
Molecular Function	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	Vax2	IDA		Mouse	MGI:MGI:3578573|PMID:15905411
Molecular Function	GO:0043565	sequence-specific DNA binding	vax2	IDA		Zfish	PMID:23669349
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	VAX2	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Vax2	IDA		Mouse	PMID:17043310
Cellular Component	GO:0005634	nucleus	Vax2	IDA		Mouse	PMID:17043310
Biological Process	GO:0007409	axonogenesis	Vax2	IMP	MGI:MGI:2159246	Mouse	PMID:11830579
Biological Process	GO:0043010	camera-type eye development	Vax2	IGI	MGI:MGI:1277163	Mouse	PMID:15905411
Biological Process	GO:0061386	closure of optic fissure	vax2	IMP		Zfish	PMID:12538521
Biological Process	GO:0009950	dorsal/ventral axis specification	Vax2	IMP	MGI:MGI:2159246	Mouse	PMID:11830579
Biological Process	GO:0009950	dorsal/ventral axis specification	Vax2	IMP	MGI:MGI:2388160	Mouse	PMID:11830578
Biological Process	GO:0048048	embryonic eye morphogenesis	Vax2	IDA		Mouse	PMID:10595508
Biological Process	GO:0048048	embryonic eye morphogenesis	Vax2	IMP	MGI:MGI:2159246	Mouse	PMID:11830579
Biological Process	GO:0030900	forebrain development	Vax2	IMP		Mouse	MGI:MGI:5289759|PMID:21856776
Biological Process	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	vax2	IGI	ZFIN:ZDB-MRPHLNO-130911-10,ZFIN:ZDB-MRPHLNO-130911-11	Zfish	PMID:23669349
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Vax2	IDA		Mouse	MGI:MGI:3578573|PMID:15905411
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Vax2	IGI	MGI:MGI:97486	Mouse	PMID:15905411
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Vax2	IGI	MGI:MGI:1277163	Mouse	PMID:15905411
Biological Process	GO:0021554	optic nerve development	vax2	IMP		Zfish	PMID:12538521
Biological Process	GO:0090259	regulation of retinal ganglion cell axon guidance	vax2	IMP		Zfish	PMID:12538521
Biological Process	GO:0060041	retina development in camera-type eye	Vax2	IDA		Mouse	PMID:10595508
Biological Process	GO:0060041	retina development in camera-type eye	vax2	IMP		Zfish	PMID:12538521
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	vax2	IGI	ZFIN:ZDB-MRPHLNO-130911-10,ZFIN:ZDB-MRPHLNO-130911-11	Zfish	PMID:23669349

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern