Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VCAM1
  • Mouse genes Vcam1
  • Rat genes Vcam1
  • Zfish genes vcam1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vcam1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0098631	cell adhesion mediator activity	VCAM1	IDA		Human	PMID:22970700
Molecular Function	GO:0050839	cell adhesion molecule binding	VCAM1	IPI	UniProtKB:P15311	Human	PMID:12082081
Molecular Function	GO:0050839	cell adhesion molecule binding	VCAM1	IPI	UniProtKB:P26038	Human	PMID:12082081
Molecular Function	GO:0050839	cell adhesion molecule binding	VCAM1	IDA		Human	PMID:1377228
Molecular Function	GO:0005178	integrin binding	VCAM1	IDA		Human	PMID:1377228
Molecular Function	GO:0005178	integrin binding	VCAM1	IDA		Human	PMID:15220135
Molecular Function	GO:0005178	integrin binding	VCAM1	IMP		Human	PMID:19738201
Molecular Function	GO:0005178	integrin binding	VCAM1	IDA		Human	PMID:23620790
Molecular Function	GO:0005178	integrin binding	Vcam1	IMP		Rat	PMID:1377031|RGD:727551
Molecular Function	GO:0008131	primary amine oxidase activity	VCAM1	IDA		Human	PMID:23474851
Cellular Component	GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex	VCAM1	IDA		Human	PMID:15220135
Cellular Component	GO:0045177	apical part of cell	VCAM1	IDA		Human	PMID:12082081
Cellular Component	GO:0016324	apical plasma membrane	Vcam1	IDA		Mouse	PMID:30236446
Cellular Component	GO:0071944	cell periphery	Vcam1	IDA		Mouse	PMID:21464233
Cellular Component	GO:0009986	cell surface	VCAM1	IDA		Human	PMID:1715889
Cellular Component	GO:0009986	cell surface	VCAM1	IDA		Human	PMID:23474851
Cellular Component	GO:0009986	cell surface	Vcam1	IDA		Rat	PMID:11870719|RGD:2313113
Cellular Component	GO:0005769	early endosome	VCAM1	IDA		Human	PMID:23474851
Cellular Component	GO:0005783	endoplasmic reticulum	VCAM1	IDA		Human	PMID:23474851
Cellular Component	GO:0009897	external side of plasma membrane	VCAM1	IDA		Human	PMID:1377228
Cellular Component	GO:0070062	extracellular exosome	VCAM1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	VCAM1	IDA		Human	PMID:9290466
Cellular Component	GO:0005615	extracellular space	Vcam1	IDA		Rat	PMID:22521742|RGD:6903281
Cellular Component	GO:0030175	filopodium	VCAM1	IDA		Human	PMID:12082081
Cellular Component	GO:0005794	Golgi apparatus	VCAM1	IDA		Human	PMID:23474851
Cellular Component	GO:0005902	microvillus	VCAM1	IDA		Human	PMID:12082081
Cellular Component	GO:0002102	podosome	VCAM1	IDA		Human	PMID:15220135
Cellular Component	GO:0042383	sarcolemma	Vcam1	IDA		Rat	PMID:11870719|RGD:2313113
Biological Process	GO:0002526	acute inflammatory response	Vcam1	IEP		Rat	PMID:8867672|RGD:2313114
Biological Process	GO:0007568	aging	Vcam1	IEP		Rat	PMID:17873024|RGD:2313112
Biological Process	GO:0009308	amine metabolic process	VCAM1	IDA		Human	PMID:23474851
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	VCAM1	IGI	UniProtKB:P20160	Human	PMID:15879141
Biological Process	GO:0060945	cardiac neuron differentiation	Vcam1	IMP		Rat	PMID:12486170|RGD:628409
Biological Process	GO:0007155	cell adhesion	VCAM1	IDA		Human	PMID:16809613
Biological Process	GO:0007155	cell adhesion	Vcam1	IDA		Mouse	PMID:12021259
Biological Process	GO:0007155	cell adhesion	Vcam1	IMP		Rat	PMID:1377031|RGD:727551
Biological Process	GO:0060326	cell chemotaxis	Vcam1	IMP		Rat	PMID:23226762|RGD:7207782
Biological Process	GO:0140039	cell-cell adhesion in response to extracellular stimulus	VCAM1	IGI	UniProtKB:P13612,UniProtKB:Q15109	Human	PMID:11078691
Biological Process	GO:0007160	cell-matrix adhesion	VCAM1	IDA		Human	PMID:18308860
Biological Process	GO:1904646	cellular response to amyloid-beta	VCAM1	IGI	UniProtKB:P13612,UniProtKB:Q15109	Human	PMID:11078691
Biological Process	GO:0071333	cellular response to glucose stimulus	Vcam1	IDA		Mouse	PMID:17670746
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Vcam1	IEP		Rat	PMID:15980038|RGD:152025214
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Vcam1	IEP		Rat	PMID:23035855|RGD:7207794
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	Vcam1	IEP		Rat	PMID:23226762|RGD:7207782
Biological Process	GO:0060710	chorio-allantoic fusion	Vcam1	IMP	MGI:MGI:1857452	Mouse	PMID:7539357
Biological Process	GO:0060710	chorio-allantoic fusion	Vcam1	IMP	MGI:MGI:2153830	Mouse	PMID:7530222
Biological Process	GO:0002544	chronic inflammatory response	Vcam1	IEP		Rat	PMID:10706728|RGD:2313132
Biological Process	GO:0060669	embryonic placenta morphogenesis	Vcam1	IMP	MGI:MGI:2153830	Mouse	PMID:7530222
Biological Process	GO:0007507	heart development	Vcam1	IMP	MGI:MGI:1857452	Mouse	PMID:7539357
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	VCAM1	IDA		Human	PMID:1715889
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	Vcam1	IMP		Mouse	PMID:8145052
Biological Process	GO:0034113	heterotypic cell-cell adhesion	VCAM1	IGI	UniProtKB:P13612,UniProtKB:Q15109	Human	PMID:11078691
Biological Process	GO:0006954	inflammatory response	VCAM1	IDA		Human	PMID:22970700
Biological Process	GO:0060384	innervation	Vcam1	IMP		Rat	PMID:12486170|RGD:628409
Biological Process	GO:0007159	leukocyte cell-cell adhesion	VCAM1	IDA		Human	PMID:1381355
Biological Process	GO:0007159	leukocyte cell-cell adhesion	VCAM1	IDA		Human	PMID:1715889
Biological Process	GO:0007159	leukocyte cell-cell adhesion	VCAM1	IDA		Human	PMID:2688898
Biological Process	GO:0007159	leukocyte cell-cell adhesion	Vcam1	IMP		Mouse	PMID:8562500
Biological Process	GO:0050901	leukocyte tethering or rolling	VCAM1	IDA		Human	PMID:18308860
Biological Process	GO:0050901	leukocyte tethering or rolling	VCAM1	IEP		Human	PMID:2688898
Biological Process	GO:0001946	lymphangiogenesis	vcam1b	IGI	ZFIN:ZDB-MRPHLNO-160113-1,ZFIN:ZDB-MRPHLNO-160113-5,ZFIN:ZDB-MRPHLNO-160218-1	Zfish	PMID:25745057
Biological Process	GO:0001946	lymphangiogenesis	vcam1b	IGI	ZFIN:ZDB-MRPHLNO-160113-1,ZFIN:ZDB-MRPHLNO-160218-1	Zfish	PMID:25745057
Biological Process	GO:0022614	membrane to membrane docking	VCAM1	IEP		Human	PMID:12082081
Biological Process	GO:0042102	positive regulation of T cell proliferation	VCAM1	IDA		Human	PMID:1381355
Biological Process	GO:0045471	response to ethanol	Vcam1	IEP		Rat	PMID:22521742|RGD:6903281
Biological Process	GO:0001666	response to hypoxia	Vcam1	IEP		Rat	PMID:19465514|RGD:2312873
Biological Process	GO:0010212	response to ionizing radiation	Vcam1	IEP		Rat	PMID:19714308|RGD:2312872
Biological Process	GO:0032496	response to lipopolysaccharide	Vcam1	IEP		Rat	PMID:22433071|RGD:7207795
Biological Process	GO:0035094	response to nicotine	Vcam1	IEP		Rat	PMID:22218593|RGD:7207799
Biological Process	GO:0007584	response to nutrient	Vcam1	IEP		Rat	PMID:19199090|RGD:2313106
Biological Process	GO:0010043	response to zinc ion	Vcam1	IEP		Rat	PMID:20128680|RGD:2317375

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern