Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VCAN
  • Mouse genes Vcan
  • Rat genes Vcan
  • Zfish genes vcana,vcanb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vcan

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	VCAN	IPI	UniProtKB:P14780	Human	PMID:23601700
Molecular Function	GO:0019903	protein phosphatase binding	Vcan	IPI	PR:A2A8L5	Mouse	PMID:21976490
Cellular Component	GO:0009986	cell surface	Vcan	IDA		Rat	PMID:12586779|RGD:1299255
Cellular Component	GO:0062023	collagen-containing extracellular matrix	VCAN	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	VCAN	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	VCAN	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	VCAN	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	VCAN	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	VCAN	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Vcan	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Vcan	IDA		Rat	PMID:12586779|RGD:1299255
Cellular Component	GO:0031012	extracellular matrix	Vcan	IDA		Mouse	PMID:14620382
Cellular Component	GO:0005576	extracellular region	VCAN	IDA		Human	PMID:25122765
Cellular Component	GO:0005576	extracellular region	VCAN	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	VCAN	HDA		Human	PMID:20551380
Cellular Component	GO:0016020	membrane	VCAN	HDA		Human	PMID:16210410
Cellular Component	GO:0072534	perineuronal net	Vcan	IDA		Rat	PMID:16644727|RGD:9589827
Cellular Component	GO:0045202	synapse	Vcan	EXP		Rat	PMID:16507876|RGD:13702274
Cellular Component	GO:0045202	synapse	Vcan	IDA		Rat	PMID:16507876|RGD:13702274
Biological Process	GO:0031103	axon regeneration	Vcan	IEP		Rat	PMID:12526031|RGD:632591
Biological Process	GO:0003203	endocardial cushion morphogenesis	vcana	IMP	ZFIN:ZDB-MRPHLNO-120404-6	Zfish	PMID:22227723
Biological Process	GO:0007507	heart development	Vcan	IMP	MGI:MGI:1857689	Mouse	PMID:9758703
Biological Process	GO:0001957	intramembranous ossification	vcanb	IMP	ZFIN:ZDB-MRPHLNO-051230-1	Zfish	PMID:15003632
Biological Process	GO:0001649	osteoblast differentiation	VCAN	HDA		Human	PMID:16210410
Biological Process	GO:0035775	pronephric glomerulus morphogenesis	vcana	IMP	ZFIN:ZDB-MRPHLNO-120404-6	Zfish	PMID:27941332
Biological Process	GO:0003093	regulation of glomerular filtration	vcana	IMP	ZFIN:ZDB-MRPHLNO-120404-6	Zfish	PMID:27941332
Biological Process	GO:0009611	response to wounding	Vcan	IEP		Rat	PMID:11896162|RGD:625393
Biological Process	GO:0001501	skeletal system development	vcanb	IMP	ZFIN:ZDB-MRPHLNO-051230-1	Zfish	PMID:15003632
Biological Process	GO:0001657	ureteric bud development	Vcan	IEP		Mouse	MGI:MGI:3655805|PMID:16545622

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern