Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VCL
  • Mouse genes Vcl
  • Rat genes Vcl
  • Zfish genes vcla,vclb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vcl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	VCL	IDA		Human	PMID:16803572
Molecular Function	GO:0045294	alpha-catenin binding	VCL	IPI	UniProtKB:P35221	Human	PMID:9700171
Molecular Function	GO:0045296	cadherin binding	VCL	HDA		Human	PMID:25468996
Molecular Function	GO:0002162	dystroglycan binding	VCL	IPI	UniProtKB:Q14118	Human	PMID:18341635
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q9Y4G6	Human	PMID:10320934
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:O15144	Human	PMID:12473693
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q9Y490	Human	PMID:15070891
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q9Y3I0	Human	PMID:15163412
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:O43707	Human	PMID:15988023
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:P12814	Human	PMID:15988023
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q9NYB9	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:P11532	Human	PMID:16803572
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:P46939	Human	PMID:16803572
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q6XVZ2	Human	PMID:16826238
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q62417-2	Human	PMID:17082770
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q6XVZ2	Human	PMID:17289036
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:P18010	Human	PMID:17932491
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:O15061	Human	PMID:18028034
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:P18010	Human	PMID:21525010
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:B0BXR4	Human	PMID:21841197
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q5VW36	Human	PMID:22427331
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q969V4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:P33151	Human	PMID:26923917
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q9Y490	Human	PMID:26923917
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:Q9NYB9	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:P49023	Human	PMID:9054445
Molecular Function	GO:0005515	protein binding	VCL	IPI	UniProtKB:O60504	Human	PMID:9885244
Molecular Function	GO:0005515	protein binding	Vcl	IPI	UniProtKB:P49024|UniProtKB:Q8VI36	Mouse	MGI:MGI:5508567|PMID:20308429
Molecular Function	GO:0005515	protein binding	Vcl	IPI	UniProtKB:Q62417	Mouse	MGI:MGI:3694165|PMID:10085297
Molecular Function	GO:0005515	protein binding	Vcl	IPI	UniProtKB:P39447	Mouse	MGI:MGI:5578691|PMID:24413171
Molecular Function	GO:0005515	protein binding	Vcl	IPI	UniProtKB:P26039	Mouse	MGI:MGI:5508567|PMID:20308429
Molecular Function	GO:0005515	protein binding	Vcl	IPI	UniProtKB:Q61210	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Vcl	IPI	UniProtKB:P49024	Mouse	MGI:MGI:5512933|PMID:23260139
Molecular Function	GO:0005515	protein binding	Vcl	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Vcl	IPI	PR:Q8CDJ8	Mouse	PMID:26437238
Molecular Function	GO:0031267	small GTPase binding	Vcl	IPI	RGD:68416	Rat	PMID:15506980|RGD:1624304
Molecular Function	GO:0031625	ubiquitin protein ligase binding	VCL	IPI	UniProtKB:O60260	Human	PMID:19725078
Cellular Component	GO:0015629	actin cytoskeleton	Vcl	IDA		Mouse	PMID:21048959
Cellular Component	GO:0005884	actin filament	Vcl	IDA		Rat	PMID:15506980|RGD:1624304
Cellular Component	GO:0005912	adherens junction	VCL	IDA		Human	PMID:20086044
Cellular Component	GO:0005912	adherens junction	VCL	IDA		Human	PMID:26923917
Cellular Component	GO:0005912	adherens junction	Vcl	IDA		Mouse	PMID:12203715
Cellular Component	GO:0005912	adherens junction	vcla	IDA		Zfish	PMID:28767718
Cellular Component	GO:0005912	adherens junction	vclb	IDA		Zfish	PMID:28767718
Cellular Component	GO:0044291	cell-cell contact zone	VCL	IMP		Human	PMID:26923917
Cellular Component	GO:0005911	cell-cell junction	VCL	IMP		Human	PMID:25753039
Cellular Component	GO:0005911	cell-cell junction	Vcl	IDA		Mouse	PMID:14657280
Cellular Component	GO:0005911	cell-cell junction	Vcl	IDA		Mouse	PMID:22984613
Cellular Component	GO:0043034	costamere	VCL	IDA		Human	PMID:9415431
Cellular Component	GO:0043034	costamere	Vcl	IDA		Mouse	PMID:15128702
Cellular Component	GO:0005737	cytoplasm	Vcl	IDA		Mouse	MGI:MGI:5582864|PMID:24036928
Cellular Component	GO:0005829	cytosol	Vcl	IDA		Rat	PMID:12629171|RGD:152995492
Cellular Component	GO:0070062	extracellular exosome	VCL	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	VCL	HDA		Human	PMID:20458337
Cellular Component	GO:1903561	extracellular vesicle	VCL	HDA		Human	PMID:24769233
Cellular Component	GO:0005916	fascia adherens	Vcl	IDA		Mouse	PMID:16481394
Cellular Component	GO:0005916	fascia adherens	Vcl	IDA		Mouse	PMID:11732910
Cellular Component	GO:0005925	focal adhesion	VCL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	VCL	IDA		Human	PMID:15070891
Cellular Component	GO:0005925	focal adhesion	VCL	IDA		Human	PMID:20086044
Cellular Component	GO:0005925	focal adhesion	VCL	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	VCL	IMP		Human	PMID:26923917
Cellular Component	GO:0005925	focal adhesion	VCL	IDA		Human	PMID:29162887
Cellular Component	GO:0005925	focal adhesion	Vcl	IDA		Mouse	MGI:MGI:5582864|PMID:24036928
Cellular Component	GO:0005925	focal adhesion	Vcl	IDA		Mouse	MGI:MGI:3689788|PMID:15883197
Cellular Component	GO:0005925	focal adhesion	Vcl	IDA		Mouse	PMID:26437238
Cellular Component	GO:0005925	focal adhesion	Vcl	IDA		Mouse	PMID:25217619
Cellular Component	GO:0005925	focal adhesion	Vcl	IDA		Rat	PMID:15506980|RGD:1624304
Cellular Component	GO:0005925	focal adhesion	vcla	IMP	ZFIN:ZDB-MRPHLNO-100114-3	Zfish	PMID:26954676
Cellular Component	GO:0005925	focal adhesion	vcla	IDA		Zfish	PMID:26954676
Cellular Component	GO:0014704	intercalated disc	Vcl	IDA		Rat	PMID:1514597|RGD:8553384
Cellular Component	GO:0005886	plasma membrane	Vcl	IDA		Mouse	PMID:16481394
Cellular Component	GO:0002102	podosome	Vcl	IDA		Mouse	PMID:17893324
Cellular Component	GO:0061826	podosome ring	Vcl	IDA		Mouse	PMID:27505886
Cellular Component	GO:0032991	protein-containing complex	VCL	IDA		Human	PMID:9700171
Cellular Component	GO:0042383	sarcolemma	Vcl	IDA		Mouse	MGI:MGI:5908525|PMID:26359501
Cellular Component	GO:0042383	sarcolemma	Vcl	IDA		Rat	PMID:1514597|RGD:8553384
Cellular Component	GO:0001725	stress fiber	Vcl	IDA		Rat	PMID:15506980|RGD:1624304
Cellular Component	GO:0030018	Z disc	Vcl	IDA		Rat	PMID:1514597|RGD:8553384
Biological Process	GO:0034333	adherens junction assembly	VCL	IMP		Human	PMID:20086044
Biological Process	GO:0043297	apical junction assembly	VCL	IMP		Human	PMID:9700171
Biological Process	GO:0003181	atrioventricular valve morphogenesis	vcla	IMP	ZFIN:ZDB-GENO-200113-3	Zfish	PMID:30635353
Biological Process	GO:0048675	axon extension	Vcl	IGI	MGI:MGI:1861437	Mouse	PMID:24623780
Biological Process	GO:0048675	axon extension	Vcl	IGI	MGI:MGI:106658	Mouse	PMID:24623780
Biological Process	GO:0007155	cell adhesion	Vcl	IDA		Mouse	PMID:12473693
Biological Process	GO:0060977	coronary vasculature morphogenesis	vclb	IMP	ZFIN:ZDB-GENO-170321-9	Zfish	PMID:27578788
Biological Process	GO:0090136	epithelial cell-cell adhesion	VCL	IMP		Human	PMID:20086044
Biological Process	GO:0060047	heart contraction	vcla	IMP	ZFIN:ZDB-MRPHLNO-100114-3	Zfish	PMID:26954676
Biological Process	GO:0060047	heart contraction	vcla	IMP	ZFIN:ZDB-MRPHLNO-100114-3	Zfish	PMID:19800866
Biological Process	GO:0007507	heart development	vclb	IMP	ZFIN:ZDB-GENO-170321-9	Zfish	PMID:27578788
Biological Process	GO:0030032	lamellipodium assembly	Vcl	IDA		Mouse	PMID:12473693
Biological Process	GO:0086013	membrane repolarization during cardiac muscle cell action potential	vcla	IMP	ZFIN:ZDB-MRPHLNO-100114-3	Zfish	PMID:24952909
Biological Process	GO:0002009	morphogenesis of an epithelium	VCL	IMP		Human	PMID:20086044
Biological Process	GO:0070527	platelet aggregation	VCL	HMP		Human	PMID:23382103
Biological Process	GO:0034394	protein localization to cell surface	VCL	IMP		Human	PMID:20086044
Biological Process	GO:0030334	regulation of cell migration	Vcl	IDA		Mouse	PMID:12473693
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	VCL	IDA		Human	PMID:26923917
Biological Process	GO:0051893	regulation of focal adhesion assembly	VCL	IMP		Human	PMID:26923917
Biological Process	GO:1904702	regulation of protein localization to adherens junction	VCL	IMP	UniProtKB:P33151	Human	PMID:26923917
Biological Process	GO:0045214	sarcomere organization	vcla	IMP	ZFIN:ZDB-MRPHLNO-100114-3	Zfish	PMID:19800866

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern