Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VDAC2
  • Mouse genes Vdac2
  • Rat genes Vdac2
  • Zfish genes vdac2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vdac2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097001	ceramide binding	VDAC2	IDA		Human	PMID:31015432
Molecular Function	GO:0015267	channel activity	vdac2	IDA		Zfish	PMID:24627492
Molecular Function	GO:0015485	cholesterol binding	VDAC2	IDA		Human	PMID:31015432
Molecular Function	GO:0042802	identical protein binding	vdac2	IPI	ZFIN:ZDB-GENE-030131-845	Zfish	PMID:24627492
Molecular Function	GO:0031210	phosphatidylcholine binding	VDAC2	IDA		Human	PMID:31015432
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:Q96A26	Human	PMID:15082785
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P21754	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:Q05996	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P21796	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:O43933	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:O60260-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:O94811	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P02766	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P04792	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P07196	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P07339	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P29692-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P42331-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P48643	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P49821	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:P60891	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:Q06787-7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:Q6NUP5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:Q8WUW1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:Q92870-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:Q9UMF0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VDAC2	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Vdac2	IPI	UniProtKB:Q8C624	Mouse	MGI:MGI:6763857|PMID:33087875
Molecular Function	GO:0005515	protein binding	Vdac2	IPI	UniProtKB:O08734	Mouse	MGI:MGI:5315363|PMID:12881569
Molecular Function	GO:0005515	protein binding	Vdac2	IPI	UniProtKB:Q80X86	Mouse	MGI:MGI:6507113|PMID:33536340
Molecular Function	GO:0005515	protein binding	Vdac2	IPI	UniProtKB:Q91W40	Mouse	MGI:MGI:5429147|PMID:22561200
Molecular Function	GO:0005515	protein binding	Vdac2	IPI	PR:Q8C624	Mouse	PMID:34446558
Molecular Function	GO:0008308	voltage-gated monoatomic anion channel activity	VDAC2	IDA		Human	PMID:8420959
Cellular Component	GO:0001669	acrosomal vesicle	VDAC2	IDA		Human	PMID:23355646
Cellular Component	GO:0016020	membrane	VDAC2	IDA		Human	PMID:27641616
Cellular Component	GO:0005743	mitochondrial inner membrane	Vdac2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0031966	mitochondrial membrane	VDAC2	IDA		Human	PMID:31015432
Cellular Component	GO:0042645	mitochondrial nucleoid	VDAC2	IDA		Human	PMID:18063578
Cellular Component	GO:0005741	mitochondrial outer membrane	VDAC2	IDA		Human	PMID:7539795
Cellular Component	GO:0005739	mitochondrion	VDAC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	VDAC2	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Vdac2	IMP	UniProtKB:Q60930	Mouse	MGI:MGI:5429147|PMID:22561200
Cellular Component	GO:0005739	mitochondrion	Vdac2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Vdac2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Vdac2	IDA		Rat	PMID:14759607|RGD:10003048
Cellular Component	GO:0005739	mitochondrion	Vdac2	IDA		Rat	PMID:17893921|RGD:10003051
Cellular Component	GO:0043209	myelin sheath	Vdac2	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	VDAC2	HDA		Human	PMID:21630459
Cellular Component	GO:0005886	plasma membrane	vdac2	IDA		Zfish	PMID:24627492
Cellular Component	GO:0097225	sperm midpiece	Vdac2	IDA		Mouse	MGI:MGI:6763857|PMID:33087875
Cellular Component	GO:0008021	synaptic vesicle	Vdac2	IDA		Rat	PMID:19187093|RGD:10003050
Biological Process	GO:0007339	binding of sperm to zona pellucida	VDAC2	IMP		Human	PMID:23355646
Biological Process	GO:0036444	calcium import into the mitochondrion	vdac2	IDA		Zfish	PMID:25588501
Biological Process	GO:0031101	fin regeneration	vdac2	IEP		Zfish	PMID:22278371
Biological Process	GO:0097345	mitochondrial outer membrane permeabilization	VDAC2	IMP		Human	PMID:31015432
Biological Process	GO:0006820	monoatomic anion transport	VDAC2	IDA		Human	PMID:8420959
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	Vdac2	IMP		Mouse	MGI:MGI:5315363|PMID:12881569
Biological Process	GO:0032272	negative regulation of protein polymerization	Vdac2	IMP		Mouse	MGI:MGI:5315363|PMID:12881569
Biological Process	GO:0008016	regulation of heart contraction	vdac2	IGI	ZFIN:ZDB-GENO-980202-1494,ZFIN:ZDB-MRPHLNO-150423-3	Zfish	PMID:25588501

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern