Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VDR
  • Mouse genes Vdr
  • Rat genes Vdr
  • Zfish genes vdra,vdrb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vdr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1902098	calcitriol binding	VDR	IDA		Human	PMID:10678179
Molecular Function	GO:1902098	calcitriol binding	VDR	IDA		Human	PMID:12016314
Molecular Function	GO:1902098	calcitriol binding	VDR	IMP		Human	PMID:28698609
Molecular Function	GO:1902098	calcitriol binding	Vdr	IDA		Rat	PMID:8179318|RGD:8158087
Molecular Function	GO:1902098	calcitriol binding	vdra	IDA		Zfish	PMID:24818857
Molecular Function	GO:0003677	DNA binding	VDR	IDA		Human	PMID:11891224
Molecular Function	GO:0003677	DNA binding	Vdr	IDA		Mouse	PMID:15601870
Molecular Function	GO:0003700	DNA-binding transcription factor activity	VDR	IDA		Human	PMID:17426122
Molecular Function	GO:0003700	DNA-binding transcription factor activity	vdra	IDA		Zfish	PMID:25279795
Molecular Function	GO:0003700	DNA-binding transcription factor activity	vdrb	IDA		Zfish	PMID:25279795
Molecular Function	GO:1902121	lithocholic acid binding	VDR	IDA		Human	PMID:12016314
Molecular Function	GO:1902121	lithocholic acid binding	vdra	IDA		Zfish	PMID:24818857
Molecular Function	GO:0038186	lithocholic acid receptor activity	VDR	IDA		Human	PMID:12016314
Molecular Function	GO:0004879	nuclear receptor activity	VDR	IDA		Human	PMID:12016314
Molecular Function	GO:0004879	nuclear receptor activity	VDR	IDA		Human	PMID:16549446
Molecular Function	GO:0004879	nuclear receptor activity	VDR	IDA		Human	PMID:17082781
Molecular Function	GO:0004879	nuclear receptor activity	VDR	IMP		Human	PMID:28698609
Molecular Function	GO:0004879	nuclear receptor activity	VDR	IDA		Human	PMID:32354638
Molecular Function	GO:0004879	nuclear receptor activity	Vdr	IDA		Mouse	PMID:15322135
Molecular Function	GO:0004879	nuclear receptor activity	Vdr	IDA		Rat	PMID:9579411|RGD:70308
Molecular Function	GO:0004879	nuclear receptor activity	vdra	IDA		Zfish	PMID:25279795
Molecular Function	GO:0004879	nuclear receptor activity	vdrb	IDA		Zfish	PMID:25279795
Molecular Function	GO:0004879	nuclear receptor activity	vdra	IDA		Zfish	PMID:17997857
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	VDR	IPI	UniProtKB:P19793	Human	PMID:17426122
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	VDR	IDA		Human	PMID:28698609
Molecular Function	GO:0003676	nucleic acid binding	VDR	EXP		Human	PMID:11980721
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q15545	Human	PMID:10409738
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q15544	Human	PMID:10744685
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q9JLI4	Human	PMID:10866662
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q15648	Human	PMID:12403843
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q15788	Human	PMID:12403843
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q13573	Human	PMID:12840015
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q15648	Human	PMID:17254542
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q15788	Human	PMID:17254542
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:P19793	Human	PMID:17426122
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q09472	Human	PMID:20089040
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:P04637	Human	PMID:20227041
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:O75528	Human	PMID:20413580
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:P26045	Human	PMID:21119599
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:P19793	Human	PMID:21478865
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q15648	Human	PMID:21478865
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q15788	Human	PMID:21478865
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:P19793	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q09472	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:P19793	Human	PMID:22179700
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:P50222	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q15645	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:P28700	Human	PMID:27728806
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q13501	Human	PMID:27728806
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q13573	Human	PMID:9632709
Molecular Function	GO:0005515	protein binding	VDR	IPI	UniProtKB:Q15648	Human	PMID:9653119
Molecular Function	GO:0005515	protein binding	Vdr	IPI	UniProtKB:Q64337	Mouse	MGI:MGI:5806982|PMID:27728806
Molecular Function	GO:0005515	protein binding	Vdr	IPI	UniProtKB:Q00403|UniProtKB:Q13573|UniProtKB:Q925T6|UniProtKB:Q9Y6Q9	Mouse	MGI:MGI:5486567|PMID:12529369
Molecular Function	GO:0005515	protein binding	Vdr	IPI	UniProtKB:Q64127	Mouse	MGI:MGI:84614|PMID:8978696
Molecular Function	GO:0005515	protein binding	Vdr	IPI	UniProtKB:P97784|UniProtKB:Q9R194	Mouse	MGI:MGI:5913754|PMID:28751364
Molecular Function	GO:0005515	protein binding	Vdr	IPI	RGD:2218	Rat	PMID:19074549|RGD:10059411
Molecular Function	GO:0005515	protein binding	Vdr	IPI	RGD:2281	Rat	PMID:20015453|RGD:4889912
Molecular Function	GO:0043565	sequence-specific DNA binding	Vdr	IDA		Rat	PMID:16481392|RGD:1580357
Molecular Function	GO:0036094	small molecule binding	VDR	EXP		Human	PMID:15728261
Molecular Function	GO:0008134	transcription factor binding	vdra	IPI	UniProtKB:Q4VW83	Zfish	PMID:20236534
Molecular Function	GO:0005499	vitamin D binding	Vdr	IDA		Rat	PMID:2829212|RGD:729973
Molecular Function	GO:0005499	vitamin D binding	Vdr	IMP		Rat	PMID:2829212|RGD:729973
Molecular Function	GO:0005499	vitamin D binding	vdra	IDA		Zfish	PMID:28399453
Molecular Function	GO:0005499	vitamin D binding	vdra	IDA		Zfish	PMID:22180837
Molecular Function	GO:0005499	vitamin D binding	vdra	IDA		Zfish	PMID:15225747
Molecular Function	GO:0070644	vitamin D response element binding	VDR	IDA		Human	PMID:17426122
Molecular Function	GO:0070644	vitamin D response element binding	vdra	IDA		Zfish	PMID:25279795
Molecular Function	GO:0070644	vitamin D response element binding	vdrb	IDA		Zfish	PMID:25279795
Cellular Component	GO:0005901	caveola	Vdr	IDA		Rat	PMID:15272054|RGD:8158089
Cellular Component	GO:0005829	cytosol	VDR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Vdr	IDA		Rat	PMID:18060514|RGD:4889988
Cellular Component	GO:0001651	dense fibrillar component	Vdr	IDA		Rat	PMID:8392883|RGD:8158086
Cellular Component	GO:0000791	euchromatin	Vdr	IDA		Rat	PMID:8392883|RGD:8158086
Cellular Component	GO:0000792	heterochromatin	Vdr	IDA		Rat	PMID:12717384|RGD:1580360
Cellular Component	GO:0000792	heterochromatin	Vdr	IDA		Rat	PMID:8392883|RGD:8158086
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Vdr	IDA		Rat	PMID:18060514|RGD:4889988
Cellular Component	GO:0016363	nuclear matrix	Vdr	IDA		Rat	PMID:9744521|RGD:8158090
Cellular Component	GO:0005654	nucleoplasm	VDR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	VDR	IDA		Human	PMID:16207705
Cellular Component	GO:0005634	nucleus	VDR	IDA		Human	PMID:15589699
Cellular Component	GO:0005634	nucleus	VDR	IDA		Human	PMID:17082781
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Vdr	IDA		Rat	PMID:9220147|RGD:8158088
Cellular Component	GO:0043235	receptor complex	VDR	IDA		Human	PMID:17426122
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	VDR	IPI		Human	PMID:22179700
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	VDR	IDA		Human	PMID:17426122
Cellular Component	GO:0030315	T-tubule	Vdr	IDA		Rat	PMID:20015453|RGD:4889912
Biological Process	GO:0007568	aging	Vdr	IEP		Rat	PMID:18060514|RGD:4889988
Biological Process	GO:0009887	animal organ morphogenesis	Vdr	IMP	MGI:MGI:1859929	Mouse	PMID:9241280
Biological Process	GO:0060057	apoptotic process involved in mammary gland involution	Vdr	IMP	MGI:MGI:2183404	Mouse	PMID:15178742
Biological Process	GO:0097190	apoptotic signaling pathway	Vdr	IDA		Rat	PMID:9579411|RGD:70308
Biological Process	GO:0038183	bile acid signaling pathway	VDR	IDA		Human	PMID:12016314
Biological Process	GO:0055074	calcium ion homeostasis	vdra	IMP	ZFIN:ZDB-MRPHLNO-121102-5	Zfish	PMID:23029160
Biological Process	GO:0006816	calcium ion transport	Vdr	IMP	MGI:MGI:2183409	Mouse	PMID:11687634
Biological Process	GO:0000902	cell morphogenesis	VDR	IMP		Human	PMID:17223341
Biological Process	GO:1904646	cellular response to amyloid-beta	Vdr	IEP		Rat	PMID:23752060|RGD:13432075
Biological Process	GO:0071305	cellular response to vitamin D	Vdr	IEP		Rat	PMID:9753201|RGD:8158092
Biological Process	GO:0046697	decidualization	VDR	IEP		Human	PMID:16720713
Biological Process	GO:0006351	DNA-templated transcription	vdra	IDA		Zfish	PMID:17997857
Biological Process	GO:0007507	heart development	Vdr	IEP		Rat	PMID:12107506|RGD:8158091
Biological Process	GO:0003146	heart jogging	vdra	IMP	ZFIN:ZDB-MRPHLNO-121102-5,ZFIN:ZDB-MRPHLNO-160408-3	Zfish	PMID:26797277
Biological Process	GO:0003146	heart jogging	vdrb	IMP	ZFIN:ZDB-MRPHLNO-121102-5,ZFIN:ZDB-MRPHLNO-160408-3	Zfish	PMID:26797277
Biological Process	GO:0001947	heart looping	vdra	IMP	ZFIN:ZDB-MRPHLNO-121102-5,ZFIN:ZDB-MRPHLNO-160408-3	Zfish	PMID:26797277
Biological Process	GO:0001947	heart looping	vdrb	IMP	ZFIN:ZDB-MRPHLNO-121102-5,ZFIN:ZDB-MRPHLNO-160408-3	Zfish	PMID:26797277
Biological Process	GO:0071425	hematopoietic stem cell proliferation	vdra	IMP	ZFIN:ZDB-GENO-170908-2	Zfish	PMID:27705794
Biological Process	GO:0071425	hematopoietic stem cell proliferation	vdra	IMP	ZFIN:ZDB-MRPHLNO-161129-4	Zfish	PMID:27705794
Biological Process	GO:0060119	inner ear receptor cell development	vdrb	IMP	ZFIN:ZDB-MRPHLNO-160408-3	Zfish	PMID:27526995
Biological Process	GO:0050892	intestinal absorption	Vdr	IMP	MGI:MGI:2183409	Mouse	PMID:11687634
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Vdr	IMP	MGI:MGI:1859929	Mouse	PMID:9241280
Biological Process	GO:0007595	lactation	Vdr	IMP	MGI:MGI:2183404	Mouse	PMID:15178742
Biological Process	GO:0060745	mammary gland branching involved in pregnancy	Vdr	IMP	MGI:MGI:2183404	Mouse	PMID:15178742
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	VDR	IDA		Human	PMID:20171278
Biological Process	GO:0007275	multicellular organism development	Vdr	IMP	MGI:MGI:1859929	Mouse	PMID:9241280
Biological Process	GO:1900155	negative regulation of bone trabecula formation	Vdr	IMP		Rat	PMID:32231239|RGD:32716373
Biological Process	GO:0008285	negative regulation of cell population proliferation	VDR	IDA		Human	PMID:16549446
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	VDR	IDA		Human	PMID:11891224
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	VDR	IMP		Human	PMID:17223341
Biological Process	GO:0030279	negative regulation of ossification	Vdr	IMP		Rat	PMID:32231239|RGD:32716373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	VDR	IDA		Human	PMID:17426122
Biological Process	GO:0001503	ossification	vdra	IMP	ZFIN:ZDB-MRPHLNO-121102-5	Zfish	PMID:23029160
Biological Process	GO:0071599	otic vesicle development	vdrb	IMP	ZFIN:ZDB-MRPHLNO-160408-3	Zfish	PMID:27526995
Biological Process	GO:0035435	phosphate ion transmembrane transport	VDR	IDA		Human	PMID:32354638
Biological Process	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution	Vdr	IMP	MGI:MGI:2183404	Mouse	PMID:15178742
Biological Process	GO:0010628	positive regulation of gene expression	VDR	IMP		Human	PMID:17223341
Biological Process	GO:0010628	positive regulation of gene expression	VDR	IMP		Human	PMID:28885847
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	VDR	IMP		Human	PMID:17082781
Biological Process	GO:2000830	positive regulation of parathyroid hormone secretion	Vdr	IMP		Rat	PMID:32231239|RGD:32716373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	VDR	IMP		Human	PMID:17082781
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	VDR	IMP		Human	PMID:17254542
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	VDR	IDA		Human	PMID:20171278
Biological Process	GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	VDR	IDA		Human	PMID:16549446
Biological Process	GO:0070564	positive regulation of vitamin D receptor signaling pathway	VDR	IDA		Human	PMID:20171278
Biological Process	GO:0060558	regulation of calcidiol 1-monooxygenase activity	Vdr	IMP		Mouse	MGI:MGI:1097206|PMID:9295274
Biological Process	GO:0051924	regulation of calcium ion transport	Vdr	IDA		Rat	PMID:18353900|RGD:4889987
Biological Process	GO:0006355	regulation of DNA-templated transcription	Vdr	IDA		Mouse	PMID:15322135
Biological Process	GO:0006355	regulation of DNA-templated transcription	vdra	IDA		Zfish	PMID:17997857
Biological Process	GO:1903412	response to bile acid	VDR	IDA		Human	PMID:12016314
Biological Process	GO:1903412	response to bile acid	VDR	IDA		Human	PMID:32354638
Biological Process	GO:0051592	response to calcium ion	Vdr	IEP		Rat	PMID:20181667|RGD:4889911
Biological Process	GO:0032355	response to estradiol	Vdr	IEP		Rat	PMID:10724336|RGD:4889992
Biological Process	GO:0001501	skeletal system development	Vdr	IMP	MGI:MGI:1859929	Mouse	PMID:9241280
Biological Process	GO:0070561	vitamin D receptor signaling pathway	VDR	IDA		Human	PMID:16549446
Biological Process	GO:0070561	vitamin D receptor signaling pathway	VDR	IMP		Human	PMID:28698609

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern