Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VHL,VHLL
  • Mouse genes Vhl
  • Rat genes Vhl
  • Zfish genes vhl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vhl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140297	DNA-binding transcription factor binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:11641274
Molecular Function	GO:0019899	enzyme binding	VHL	IPI	UniProtKB:Q9NWT6	Human	PMID:11641274
Molecular Function	GO:0060090	molecular adaptor activity	VHL	EXP		Human	PMID:10205047
Molecular Function	GO:0060090	molecular adaptor activity	VHL	EXP		Human	PMID:12004076
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:11292862
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q61221	Human	PMID:11292862
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:O15379	Human	PMID:11641274
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q13547	Human	PMID:11641274
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:11641274
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q92769	Human	PMID:11641274
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q9NWT6	Human	PMID:11641274
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q8TEY7	Human	PMID:11739384
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:12004076
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q8WU17	Human	PMID:12032852
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:12050673
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q6IE81	Human	PMID:12169691
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q6IE81-3	Human	PMID:12169691
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q6IE81-3,UniProtKB:Q6IE81-3	Human	PMID:12169691
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q13617	Human	PMID:15601820
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:15721254
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P22557	Human	PMID:16234850
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:16511565
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q05513	Human	PMID:17350623
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:17353276
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P02751	Human	PMID:18323857
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q13617	Human	PMID:18323857
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:18323857
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q99814	Human	PMID:19208626
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P07550	Human	PMID:19584355
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q9UM11	Human	PMID:20802534
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P63244	Human	PMID:20871634
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q13617	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:21602890
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P21980	Human	PMID:21625219
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:A6NIX2	Human	PMID:22286099
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q96IF1	Human	PMID:22286099
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q9UGP4	Human	PMID:22286099
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P62877,UniProtKB:Q13617	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P62877,UniProtKB:Q13617,UniProtKB:Q15370,UniProtKB:Q16665	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P62877,UniProtKB:Q13617,UniProtKB:Q16665	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P62877,UniProtKB:Q13617,UniProtKB:Q16665,UniProtKB:Q16665	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P62877,UniProtKB:Q13617,UniProtKB:Q99814	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q13617,UniProtKB:Q16665,UniProtKB:Q96GG9	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q96GG9	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q99873	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P14866	Human	PMID:23976881
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:24899725
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q99497	Human	PMID:24899725
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q16665	Human	PMID:25438054
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q13617	Human	PMID:25661653
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:P0C6X7:PRO_0000037322	Human	PMID:25732088
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q99750	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q15369	Human	PMID:7660122
Molecular Function	GO:0005515	protein binding	VHL	IPI	UniProtKB:Q15370	Human	PMID:7660122
Molecular Function	GO:0005515	protein binding	VHLL	IPI	UniProtKB:Q15038	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	VHLL	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	VHLL	IPI	UniProtKB:O95231	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VHLL	IPI	UniProtKB:Q08AM6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VHLL	IPI	UniProtKB:Q15038	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VHLL	IPI	UniProtKB:Q93062-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Vhl	IPI	PR:P62878	Mouse	PMID:15601820
Molecular Function	GO:0005515	protein binding	Vhl	IPI	PR:Q9D4H8	Mouse	PMID:15601820
Molecular Function	GO:0005515	protein binding	Vhl	IPI	PR:P83940	Mouse	PMID:15601820
Molecular Function	GO:0005515	protein binding	Vhl	IPI	PR:P62869	Mouse	PMID:15601820
Molecular Function	GO:0005515	protein binding	Vhl	IPI	RGD:61928	Rat	PMID:19950214|RGD:2317359
Molecular Function	GO:0044877	protein-containing complex binding	Vhl	IDA		Mouse	PMID:17825299
Molecular Function	GO:0044877	protein-containing complex binding	Vhl	IPI	RGD:1310644|RGD:1308453|RGD:620658|RGD:621200	Rat	PMID:10213691|RGD:2301042
Molecular Function	GO:0044877	protein-containing complex binding	Vhl	IPI	RGD:734149|RGD:733902	Rat	PMID:9122164|RGD:1559276
Molecular Function	GO:0003711	transcription elongation factor activity	VHL	IDA		Human	PMID:7660122
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	VHL	IDA		Human	PMID:24899725
Cellular Component	GO:0005929	cilium	Vhl	IDA		Mouse	PMID:17825299
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	Vhl	IDA		Mouse	PMID:16129783
Cellular Component	GO:0005737	cytoplasm	Vhl	IDA		Mouse	PMID:16129783
Cellular Component	GO:0005829	cytosol	Vhl	IDA		Rat	PMID:7604013|RGD:730251
Cellular Component	GO:0098978	glutamatergic synapse	Vhl	IMP		Mouse	PMID:26972007
Cellular Component	GO:0098978	glutamatergic synapse	Vhl	IPI		Mouse	PMID:26972007
Cellular Component	GO:0098978	glutamatergic synapse	Vhl	IEP		Mouse	PMID:26972007
Cellular Component	GO:0098978	glutamatergic synapse	Vhl	IDA		Mouse	PMID:26972007
Cellular Component	GO:0043232	intracellular non-membrane-bounded organelle	VHL	EXP		Human	PMID:14963040
Cellular Component	GO:0005739	mitochondrion	Vhl	IDA		Rat	PMID:10850420|RGD:2325198
Cellular Component	GO:0005730	nucleolus	Vhl	IDA		Mouse	PMID:16129783
Cellular Component	GO:0005654	nucleoplasm	VHL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	Vhl	IDA		Mouse	PMID:16129783
Cellular Component	GO:0005634	nucleus	Vhl	IDA		Mouse	PMID:16129783
Cellular Component	GO:0005634	nucleus	Vhl	IDA		Rat	PMID:7604013|RGD:730251
Cellular Component	GO:0014069	postsynaptic density	Vhl	IEP		Mouse	PMID:26972007
Cellular Component	GO:0014069	postsynaptic density	Vhl	IDA		Mouse	PMID:26972007
Cellular Component	GO:0030891	VCB complex	Vhl	IDA		Rat	PMID:10213691|RGD:2301042
Cellular Component	GO:0030891	VCB complex	Vhl	IDA		Rat	PMID:9122164|RGD:1559276
Biological Process	GO:1990000	amyloid fibril formation	VHL	EXP		Human	PMID:34431623
Biological Process	GO:1990000	amyloid fibril formation	VHL	IDA		Human	PMID:34431623
Biological Process	GO:0001525	angiogenesis	Vhl	IMP	MGI:MGI:2136645,MGI:MGI:2450311	Mouse	PMID:16537898
Biological Process	GO:0001525	angiogenesis	vhl	IMP	ZFIN:ZDB-GENO-131203-2	Zfish	PMID:26506092
Biological Process	GO:0001525	angiogenesis	vhl	IGI	ZFIN:ZDB-GENE-050407-1	Zfish	PMID:28071661
Biological Process	GO:0043534	blood vessel endothelial cell migration	Vhl	IMP	MGI:MGI:2136645,MGI:MGI:2450311	Mouse	PMID:16537898
Biological Process	GO:0048593	camera-type eye morphogenesis	Vhl	IGI	MGI:MGI:106918	Mouse	PMID:22627278
Biological Process	GO:0048593	camera-type eye morphogenesis	Vhl	IMP	MGI:MGI:2136645	Mouse	PMID:22627278
Biological Process	GO:0061073	ciliary body morphogenesis	Vhl	IMP	MGI:MGI:2136645	Mouse	PMID:22627278
Biological Process	GO:0006281	DNA repair	vhl	IGI	ZFIN:ZDB-FISH-210608-4	Zfish	PMID:32284789
Biological Process	GO:0045446	endothelial cell differentiation	Vhl	IMP	MGI:MGI:2136645,MGI:MGI:3608931	Mouse	PMID:25186293
Biological Process	GO:0030218	erythrocyte differentiation	vhl	IMP	ZFIN:ZDB-GENO-090611-18	Zfish	PMID:19304954
Biological Process	GO:0030218	erythrocyte differentiation	vhl	IMP	ZFIN:ZDB-GENO-090612-3	Zfish	PMID:19304954
Biological Process	GO:0030218	erythrocyte differentiation	vhl	IMP	ZFIN:ZDB-GENO-090611-17	Zfish	PMID:19304954
Biological Process	GO:0030198	extracellular matrix organization	Vhl	IMP	MGI:MGI:2136645,MGI:MGI:2450311	Mouse	PMID:16537898
Biological Process	GO:0048069	eye pigmentation	Vhl	IMP	MGI:MGI:2136645	Mouse	PMID:22627278
Biological Process	GO:0060218	hematopoietic stem cell differentiation	vhl	IMP	ZFIN:ZDB-MRPHLNO-130514-1	Zfish	PMID:27751871
Biological Process	GO:0060218	hematopoietic stem cell differentiation	vhl	IGI	ZFIN:ZDB-GENE-030805-2	Zfish	PMID:27751871
Biological Process	GO:0030097	hemopoiesis	vhl	IMP	ZFIN:ZDB-GENO-090612-3	Zfish	PMID:19304954
Biological Process	GO:0030097	hemopoiesis	vhl	IMP	ZFIN:ZDB-GENO-090611-18	Zfish	PMID:19304954
Biological Process	GO:0030097	hemopoiesis	vhl	IMP	ZFIN:ZDB-GENO-090611-17	Zfish	PMID:19304954
Biological Process	GO:0048877	homeostasis of number of retina cells	Vhl	IMP	MGI:MGI:2136645	Mouse	PMID:22627278
Biological Process	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	Vhl	IMP	MGI:MGI:2136645,MGI:MGI:3608931	Mouse	PMID:25186293
Biological Process	GO:0061072	iris morphogenesis	Vhl	IMP	MGI:MGI:2136645	Mouse	PMID:22627278
Biological Process	GO:0061072	iris morphogenesis	Vhl	IGI	MGI:MGI:106918	Mouse	PMID:22627278
Biological Process	GO:0006582	melanin metabolic process	Vhl	IMP	MGI:MGI:2136645	Mouse	PMID:22627278
Biological Process	GO:0010507	negative regulation of autophagy	VHL	IDA		Human	PMID:30902965
Biological Process	GO:0008285	negative regulation of cell population proliferation	VHL	IDA		Human	PMID:23338840
Biological Process	GO:0008285	negative regulation of cell population proliferation	VHL	IMP		Human	PMID:23338840
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	Vhl	IMP	MGI:MGI:2136645,MGI:MGI:3608931	Mouse	PMID:25186293
Biological Process	GO:0010629	negative regulation of gene expression	VHL	IMP		Human	PMID:23338840
Biological Process	GO:0010629	negative regulation of gene expression	Vhl	IMP	MGI:MGI:2136645	Mouse	PMID:22627278
Biological Process	GO:1902072	negative regulation of hypoxia-inducible factor-1alpha signaling pathway	Vhl	IMP	MGI:MGI:2136645,MGI:MGI:3608931	Mouse	PMID:25186293
Biological Process	GO:1902072	negative regulation of hypoxia-inducible factor-1alpha signaling pathway	vhl	IMP	ZFIN:ZDB-GENO-210721-2	Zfish	PMID:32379754
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	VHL	IMP		Human	PMID:23338840
Biological Process	GO:0009968	negative regulation of signal transduction	VHL	EXP		Human	PMID:23338840
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	Vhl	IMP	MGI:MGI:2136645,MGI:MGI:2448686	Mouse	PMID:15456877
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Vhl	IMP		Rat	PMID:11912140|RGD:619592
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	VHL	IDA		Human	PMID:7660122
Biological Process	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia	VHL	IDA		Human	PMID:11641274
Biological Process	GO:0030182	neuron differentiation	Vhl	IDA		Rat	PMID:20125055|RGD:2325181
Biological Process	GO:0003310	pancreatic A cell differentiation	Vhl	IMP	MGI:MGI:2136645,MGI:MGI:3608931	Mouse	PMID:25186293
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	VHL	IMP		Human	PMID:17973242
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Vhl	IMP	MGI:MGI:2136645	Mouse	PMID:22627278
Biological Process	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway	vhl	IMP	ZFIN:ZDB-GENO-210721-2	Zfish	PMID:32379754
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	VHL	IDA		Human	PMID:10823831
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	VHL	IEP		Human	PMID:10973499
Biological Process	GO:0039022	pronephric duct development	vhl	IMP	ZFIN:ZDB-GENO-090611-18	Zfish	PMID:27491085
Biological Process	GO:0048793	pronephros development	vhl	IMP	ZFIN:ZDB-MRPHLNO-130514-1	Zfish	PMID:26194803
Biological Process	GO:0048793	pronephros development	vhl	IMP	ZFIN:ZDB-GENO-090611-17	Zfish	PMID:29342457
Biological Process	GO:0010498	proteasomal protein catabolic process	Vhl	IMP		Mouse	PMID:17981124
Biological Process	GO:0030163	protein catabolic process	Vhl	IMP		Mouse	PMID:12832481
Biological Process	GO:0015031	protein transport	Vhl	IDA		Mouse	PMID:16129783
Biological Process	GO:0016567	protein ubiquitination	VHL	IMP		Human	PMID:12169691
Biological Process	GO:0016567	protein ubiquitination	VHL	IDA		Human	PMID:24899725
Biological Process	GO:0045765	regulation of angiogenesis	vhl	IMP	ZFIN:ZDB-GENO-090612-3	Zfish	PMID:20335444
Biological Process	GO:2001233	regulation of apoptotic signaling pathway	Vhl	IGI	MGI:MGI:1261423	Mouse	PMID:15456877
Biological Process	GO:0042069	regulation of catecholamine metabolic process	Vhl	IMP		Rat	PMID:11912140|RGD:619592
Biological Process	GO:1900037	regulation of cellular response to hypoxia	VHL	EXP		Human	PMID:10205047
Biological Process	GO:0006355	regulation of DNA-templated transcription	VHL	IMP		Human	PMID:15824735
Biological Process	GO:0006355	regulation of DNA-templated transcription	Vhl	IDA		Rat	PMID:1966765|RGD:61592
Biological Process	GO:0010468	regulation of gene expression	VHL	EXP		Human	PMID:15824735
Biological Process	GO:0010468	regulation of gene expression	VHL	IEP		Human	PMID:15824735
Biological Process	GO:0010468	regulation of gene expression	VHL	IDA		Human	PMID:17973242
Biological Process	GO:0010468	regulation of gene expression	VHL	IEP		Human	PMID:17973242
Biological Process	GO:0010468	regulation of gene expression	VHL	IDA		Human	PMID:23338840
Biological Process	GO:0010468	regulation of gene expression	Vhl	IMP	MGI:MGI:2136645	Mouse	PMID:22627278
Biological Process	GO:0099175	regulation of postsynapse organization	Vhl	IPI		Mouse	PMID:26972007
Biological Process	GO:0099175	regulation of postsynapse organization	Vhl	IDA		Mouse	PMID:26972007
Biological Process	GO:0099175	regulation of postsynapse organization	Vhl	IMP		Mouse	PMID:26972007
Biological Process	GO:0099175	regulation of postsynapse organization	Vhl	IEP		Mouse	PMID:26972007
Biological Process	GO:0032880	regulation of protein localization	Vhl	IMP		Mouse	PMID:22627278
Biological Process	GO:0043576	regulation of respiratory gaseous exchange	vhl	IMP	ZFIN:ZDB-GENO-160427-4	Zfish	PMID:26179906
Biological Process	GO:0070243	regulation of thymocyte apoptotic process	Vhl	IGI	MGI:MGI:1261423	Mouse	PMID:15456877
Biological Process	GO:0070243	regulation of thymocyte apoptotic process	Vhl	IGI	MGI:MGI:106918	Mouse	PMID:15456877
Biological Process	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	vhl	IMP	ZFIN:ZDB-GENO-090612-3	Zfish	PMID:20335444
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	Vhl	IDA		Mouse	PMID:26972007
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	Vhl	IMP		Mouse	PMID:26972007
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	Vhl	IEP		Mouse	PMID:26972007
Biological Process	GO:0045471	response to ethanol	Vhl	IEP		Rat	PMID:15507234|RGD:2325196
Biological Process	GO:0001666	response to hypoxia	Vhl	IMP		Rat	PMID:11912140|RGD:619592
Biological Process	GO:0061912	selective autophagy	VHL	IMP		Human	PMID:30902965
Biological Process	GO:0003309	type B pancreatic cell differentiation	Vhl	IMP	MGI:MGI:2136645,MGI:MGI:3608931	Mouse	PMID:25186293

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern