Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VIL1
  • Mouse genes Vil1
  • Rat genes Vil1
  • Zfish genes vil1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vil1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	VIL1	IDA		Human	PMID:11500485
Molecular Function	GO:0051015	actin filament binding	VIL1	IDA		Human	PMID:15096633
Molecular Function	GO:0051015	actin filament binding	VIL1	IDA		Human	PMID:19808673
Molecular Function	GO:0005509	calcium ion binding	VIL1	IDA		Human	PMID:11500485
Molecular Function	GO:0005509	calcium ion binding	VIL1	IMP		Human	PMID:15272027
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Vil1	IMP		Mouse	MGI:MGI:3790913|PMID:18198174
Molecular Function	GO:0042802	identical protein binding	VIL1	IPI	UniProtKB:P09327	Human	PMID:17606613
Molecular Function	GO:0035727	lysophosphatidic acid binding	VIL1	IDA		Human	PMID:19808673
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	VIL1	IDA		Human	PMID:14594952
Molecular Function	GO:0005515	protein binding	VIL1	IPI	UniProtKB:P19174	Human	PMID:16921170
Molecular Function	GO:0005515	protein binding	VIL1	IPI	UniProtKB:P19174	Human	PMID:17229814
Molecular Function	GO:0005515	protein binding	Vil1	IPI	UniProtKB:Q62077	Mouse	MGI:MGI:5009178|PMID:12937273
Molecular Function	GO:0005515	protein binding	Vil1	IPI	PR:B0V2N1	Mouse	PMID:24385580
Molecular Function	GO:0042803	protein homodimerization activity	VIL1	IDA		Human	PMID:17606613
Cellular Component	GO:0032432	actin filament bundle	VIL1	IDA		Human	PMID:17182858
Cellular Component	GO:0005903	brush border	Vil1	IDA		Mouse	MGI:MGI:5621262|PMID:22114352
Cellular Component	GO:0005903	brush border	Vil1	IDA		Mouse	PMID:33129760
Cellular Component	GO:0070062	extracellular exosome	VIL1	HDA		Human	PMID:19056867
Cellular Component	GO:0030175	filopodium	VIL1	IDA		Human	PMID:15342783
Cellular Component	GO:0030175	filopodium	Vil1	IDA		Mouse	MGI:MGI:4943407|PMID:16008578
Cellular Component	GO:0032433	filopodium tip	Vil1	IDA		Mouse	MGI:MGI:4943407|PMID:16008578
Cellular Component	GO:0030027	lamellipodium	VIL1	IDA		Human	PMID:16921170
Cellular Component	GO:0030027	lamellipodium	VIL1	IDA		Human	PMID:17229814
Cellular Component	GO:0030027	lamellipodium	VIL1	IDA		Human	PMID:17606613
Cellular Component	GO:0030027	lamellipodium	VIL1	IDA		Human	PMID:18054784
Cellular Component	GO:0030027	lamellipodium	Vil1	IDA		Mouse	MGI:MGI:5009178|PMID:12937273
Cellular Component	GO:0005902	microvillus	VIL1	IDA		Human	PMID:17182858
Cellular Component	GO:0005902	microvillus	Vil1	IDA		Mouse	PMID:21606356
Cellular Component	GO:0005886	plasma membrane	VIL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001726	ruffle	VIL1	IDA		Human	PMID:15342783
Cellular Component	GO:0001726	ruffle	VIL1	IDA		Human	PMID:17229814
Cellular Component	GO:0001726	ruffle	VIL1	IDA		Human	PMID:17606613
Biological Process	GO:0051693	actin filament capping	VIL1	IDA		Human	PMID:16921170
Biological Process	GO:0051693	actin filament capping	VIL1	IDA		Human	PMID:17182858
Biological Process	GO:0051693	actin filament capping	VIL1	IDA		Human	PMID:19808673
Biological Process	GO:0030042	actin filament depolymerization	VIL1	IDA		Human	PMID:11500485
Biological Process	GO:0030041	actin filament polymerization	VIL1	IDA		Human	PMID:11500485
Biological Process	GO:0051014	actin filament severing	VIL1	IDA		Human	PMID:16921170
Biological Process	GO:0051014	actin filament severing	VIL1	IDA		Human	PMID:17182858
Biological Process	GO:0051014	actin filament severing	VIL1	IDA		Human	PMID:19808673
Biological Process	GO:0051016	barbed-end actin filament capping	VIL1	IMP		Human	PMID:15272027
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	VIL1	IDA		Human	PMID:17229814
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	Vil1	IDA		Mouse	MGI:MGI:5009178|PMID:12937273
Biological Process	GO:0060327	cytoplasmic actin-based contraction involved in cell motility	VIL1	IDA		Human	PMID:15342783
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	VIL1	IDA		Human	PMID:17229814
Biological Process	GO:0030855	epithelial cell differentiation	VIL1	IEP		Human	PMID:21492153
Biological Process	GO:0001951	intestinal D-glucose absorption	Vil1	IGI	UniProtKB:P26040|UniProtKB:Q3V0K9	Mouse	MGI:MGI:5621262|PMID:22114352
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	VIL1	IDA		Human	PMID:19808673
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	VIL1	IMP		Human	PMID:15272027
Biological Process	GO:0030335	positive regulation of cell migration	VIL1	IDA		Human	PMID:16921170
Biological Process	GO:0010634	positive regulation of epithelial cell migration	VIL1	IDA		Human	PMID:17229814
Biological Process	GO:0010634	positive regulation of epithelial cell migration	VIL1	IGI	UniProtKB:Q13822	Human	PMID:18054784
Biological Process	GO:0010634	positive regulation of epithelial cell migration	VIL1	IMP		Human	PMID:18054784
Biological Process	GO:2000394	positive regulation of lamellipodium morphogenesis	VIL1	IGI	UniProtKB:Q13822	Human	PMID:18054784
Biological Process	GO:2000394	positive regulation of lamellipodium morphogenesis	VIL1	IMP		Human	PMID:18054784
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Vil1	IGI	UniProtKB:P26040|UniProtKB:Q3V0K9	Mouse	MGI:MGI:5621262|PMID:22114352
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	Vil1	IGI	UniProtKB:P26040|UniProtKB:Q3V0K9	Mouse	MGI:MGI:5621262|PMID:22114352
Biological Process	GO:0051125	regulation of actin nucleation	VIL1	IDA		Human	PMID:16921170
Biological Process	GO:0051125	regulation of actin nucleation	VIL1	IDA		Human	PMID:17182858
Biological Process	GO:0051125	regulation of actin nucleation	VIL1	IDA		Human	PMID:19808673
Biological Process	GO:0008360	regulation of cell shape	VIL1	IDA		Human	PMID:16921170
Biological Process	GO:2000392	regulation of lamellipodium morphogenesis	Vil1	IDA		Mouse	MGI:MGI:5009178|PMID:12937273
Biological Process	GO:0032532	regulation of microvillus length	Vil1	IGI	UniProtKB:P26040|UniProtKB:Q3V0K9	Mouse	MGI:MGI:5621262|PMID:22114352
Biological Process	GO:0061041	regulation of wound healing	Vil1	IDA		Mouse	MGI:MGI:5009178|PMID:12937273
Biological Process	GO:0009617	response to bacterium	VIL1	IDA		Human	PMID:17182858
Biological Process	GO:1902896	terminal web assembly	Vil1	IGI	UniProtKB:P26040|UniProtKB:Q3V0K9	Mouse	MGI:MGI:5621262|PMID:22114352

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern