Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VKORC1
  • Mouse genes Vkorc1
  • Rat genes Vkorc1
  • Zfish genes vkorc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vkorc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q19QW4	Human	PMID:22046132
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:A0A0S2Z4U3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:O15393-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:P15941-11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q13323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q5T7V8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q7Z7G2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q8TBB6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q96KR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q96TC7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q9NQG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q9NR31	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VKORC1	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0047058	vitamin-K-epoxide reductase (warfarin-insensitive) activity	VKORC1	IDA		Human	PMID:33154105
Molecular Function	GO:0047058	vitamin-K-epoxide reductase (warfarin-insensitive) activity	Vkorc1	IDA		Rat	PMID:11341364|RGD:1600459
Molecular Function	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	VKORC1	IDA		Human	PMID:16270630
Molecular Function	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	VKORC1	IDA		Human	PMID:33154105
Molecular Function	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	Vkorc1	IDA		Mouse	PMID:15879509
Molecular Function	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	Vkorc1	IDA		Rat	PMID:15640149|RGD:1600457
Cellular Component	GO:0005783	endoplasmic reticulum	VKORC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005789	endoplasmic reticulum membrane	VKORC1	IDA		Human	PMID:22923610
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Vkorc1	IDA		Rat	PMID:15075329|RGD:1600458
Biological Process	GO:0007596	blood coagulation	VKORC1	IMP		Human	PMID:16270630
Biological Process	GO:0007596	blood coagulation	Vkorc1	IMP		Mouse	MGI:MGI:5559848|PMID:19492146
Biological Process	GO:0060348	bone development	Vkorc1	IMP		Mouse	MGI:MGI:5559848|PMID:19492146
Biological Process	GO:0017187	peptidyl-glutamic acid carboxylation	VKORC1	IMP		Human	PMID:20978134
Biological Process	GO:0050820	positive regulation of coagulation	Vkorc1	IMP	MGI:MGI:3605979	Mouse	PMID:15879509
Biological Process	GO:0030193	regulation of blood coagulation	Vkorc1	IMP		Rat	PMID:14765194|RGD:1303972
Biological Process	GO:0046677	response to antibiotic	Vkorc1	IDA		Rat	PMID:2764989|RGD:1600463
Biological Process	GO:0014070	response to organic cyclic compound	Vkorc1	IDA		Rat	PMID:12832152|RGD:1600464
Biological Process	GO:0010243	response to organonitrogen compound	Vkorc1	IDA		Rat	PMID:2319331|RGD:1600461
Biological Process	GO:0042373	vitamin K metabolic process	VKORC1	IDA		Human	PMID:16270630
Biological Process	GO:0042373	vitamin K metabolic process	VKORC1	IDA		Human	PMID:33154105
Biological Process	GO:0042373	vitamin K metabolic process	Vkorc1	IMP		Mouse	MGI:MGI:5559848|PMID:19492146
Biological Process	GO:0042373	vitamin K metabolic process	Vkorc1	IDA		Mouse	PMID:15879509
Biological Process	GO:0006805	xenobiotic metabolic process	VKORC1	IMP		Human	PMID:21127708

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern