Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VPS18
  • Mouse genes Vps18
  • Rat genes Vps18
  • Zfish genes vps18
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vps18

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Vps18	IDA		Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:O15400	Human	PMID:11382755
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q63615	Human	PMID:11382755
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9H269	Human	PMID:11382755
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9H270	Human	PMID:11382755
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q7L1V2	Human	PMID:20434987
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9UMS6	Human	PMID:23434281
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:P49754	Human	PMID:23901104
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9H269	Human	PMID:23901104
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9H270	Human	PMID:23901104
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9H267	Human	PMID:23918659
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q96AX1	Human	PMID:24554770
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q96AX1	Human	PMID:25783203
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9H269	Human	PMID:25783203
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:P49754	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q96AX1	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9H269	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9H270	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9Y4G2	Human	PMID:28325809
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q9H270	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:P49754	Human	PMID:33422265
Molecular Function	GO:0005515	protein binding	VPS18	IPI	UniProtKB:Q96JC1	Human	PMID:33422265
Molecular Function	GO:0005515	protein binding	Vps18	IPI	UniProtKB:Q9H9C1	Mouse	MGI:MGI:4441246|PMID:19109425
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:O70439	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:P97390	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:O70404	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:O88384	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:Q5KU39	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:Q8BIL5	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:Q9JKK1	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:Q8R5L3	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:Q91W86	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:Q920Q4	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	PR:Q9ER00	Mouse	PMID:14668490
Molecular Function	GO:0005515	protein binding	Vps18	IPI	RGD:619747|RGD:1560511|RGD:1304858|RGD:621267|RGD:61915|RGD:620977|RGD:620421|RGD:1309987	Rat	PMID:14668490|RGD:1549677
Molecular Function	GO:0005515	protein binding	Vps18	IPI	UniProtKB:D3ZB48	Rat	PMID:14668490|RGD:1549677
Molecular Function	GO:0019905	syntaxin binding	VPS18	IDA		Human	PMID:11382755
Molecular Function	GO:0061630	ubiquitin protein ligase activity	VPS18	IMP		Human	PMID:31015428
Cellular Component	GO:0005884	actin filament	Vps18	IDA		Mouse	PMID:14668490
Cellular Component	GO:0030123	AP-3 adaptor complex	Vps18	IDA		Mouse	MGI:MGI:5645203|PMID:21411634
Cellular Component	GO:0033263	CORVET complex	Vps18	IDA		Mouse	MGI:MGI:5645189|PMID:25266290
Cellular Component	GO:0005769	early endosome	Vps18	IDA		Mouse	PMID:14668490
Cellular Component	GO:0098978	glutamatergic synapse	VPS18	EXP		Human	PMID:17027648
Cellular Component	GO:0098978	glutamatergic synapse	VPS18	IDA		Human	PMID:17027648
Cellular Component	GO:0098978	glutamatergic synapse	VPS18	IMP		Human	PMID:17027648
Cellular Component	GO:0030897	HOPS complex	VPS18	IDA		Human	PMID:19109425
Cellular Component	GO:0030897	HOPS complex	VPS18	IDA		Human	PMID:23901104
Cellular Component	GO:0005770	late endosome	VPS18	IDA		Human	PMID:11382755
Cellular Component	GO:0005765	lysosomal membrane	VPS18	HDA		Human	PMID:17897319
Cellular Component	GO:0005764	lysosome	VPS18	IDA		Human	PMID:11382755
Cellular Component	GO:0005764	lysosome	VPS18	IDA		Human	PMID:21802320
Cellular Component	GO:0098793	presynapse	Vps18	IDA		Rat	PMID:17027648|RGD:13702280
Biological Process	GO:0045176	apical protein localization	vps18	IMP	ZFIN:ZDB-GENO-020426-28	Zfish	PMID:16000385
Biological Process	GO:0015721	bile acid and bile salt transport	vps18	IMP	ZFIN:ZDB-GENO-020426-28	Zfish	PMID:16000385
Biological Process	GO:0007032	endosome organization	VPS18	IDA		Human	PMID:18799622
Biological Process	GO:0007032	endosome organization	Vps18	IDA		Mouse	PMID:14668490
Biological Process	GO:0008333	endosome to lysosome transport	VPS18	IMP		Human	PMID:25783203
Biological Process	GO:0008333	endosome to lysosome transport	vps18	IMP	ZFIN:ZDB-GENO-020426-28	Zfish	PMID:16000385
Biological Process	GO:0043485	endosome to pigment granule transport	vps18	IMP	ZFIN:ZDB-GENO-020426-28	Zfish	PMID:16000385
Biological Process	GO:0048069	eye pigmentation	vps18	IMP	ZFIN:ZDB-GENO-020426-28	Zfish	PMID:16827750
Biological Process	GO:0007040	lysosome organization	VPS18	IDA		Human	PMID:18799622
Biological Process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	VPS18	IGI	UniProtKB:Q9H270	Human	PMID:31015428
Biological Process	GO:0060036	notochord cell vacuolation	vps18	IMP	ZFIN:ZDB-GENO-100415-2	Zfish	PMID:23460678
Biological Process	GO:0007634	optokinetic behavior	vps18	IMP	ZFIN:ZDB-GENO-020426-28	Zfish	PMID:16827750
Biological Process	GO:0048757	pigment granule maturation	vps18	IMP	ZFIN:ZDB-GENO-020426-28	Zfish	PMID:16000385
Biological Process	GO:0048757	pigment granule maturation	vps18	IMP	ZFIN:ZDB-GENO-020426-28	Zfish	PMID:16827750
Biological Process	GO:0016567	protein ubiquitination	VPS18	IMP		Human	PMID:31015428
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	VPS18	EXP		Human	PMID:17027648
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	VPS18	IDA		Human	PMID:17027648
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	VPS18	IMP		Human	PMID:17027648
Biological Process	GO:0046718	viral entry into host cell	Vps18	IMP		Mouse	PMID:24550300

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern