Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Vps35

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes VPS35
- Mouse genes Vps35
- Rat genes Vps35
- Zfish genes vps35
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vps35

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031748	D1 dopamine receptor binding	VPS35	IPI	UniProtKB:P21728	Human	PMID:27460146
Molecular Function	GO:0031748	D1 dopamine receptor binding	Vps35	IPI	UniProtKB:Q61616	Mouse	MGI:MGI:5796045\|PMID:27460146
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:11102511
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q13596	Human	PMID:11102511
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0	Human	PMID:11102511
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:15078903
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:16732284
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:17616579
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:17891154
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0	Human	PMID:17891154
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q5T9L3	Human	PMID:18160348
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9H4A6	Human	PMID:19553991
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UNH7	Human	PMID:19619496
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9Y5X3	Human	PMID:19619496
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q92609	Human	PMID:20923837
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9QZ88	Human	PMID:20923837
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O60493	Human	PMID:21725319
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O60493	Human	PMID:22719997
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q13596	Human	PMID:22719997
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UMY4	Human	PMID:22719997
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:P40336	Human	PMID:23331060
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q12768	Human	PMID:23331060
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9QZ88	Human	PMID:23331060
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9Y4E1	Human	PMID:23331060
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UJ55	Human	PMID:23452853
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:24152121
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9QZ88	Human	PMID:24152121
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0	Human	PMID:24152121
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O60493	Human	PMID:24344282
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:P51149	Human	PMID:24344282
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:24747528
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0	Human	PMID:24747528
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:24980502
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q4G0F5	Human	PMID:24980502
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q92609	Human	PMID:24980502
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0	Human	PMID:24980502
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9Y4E1	Human	PMID:24980502
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q96C92	Human	PMID:25278552
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9ULJ7	Human	PMID:25278552
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q4G0F5	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O00429	Human	PMID:26618722
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:27385586
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:P20645	Human	PMID:27385586
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q92609	Human	PMID:27385586
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q96L92	Human	PMID:27385586
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0	Human	PMID:27385586
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:P12023	Human	PMID:27460146
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q61616	Human	PMID:27460146
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q4G0F5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436\|UniProtKB:Q9UBQ0	Human	PMID:28892079
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O60493	Human	PMID:30213940
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:O75436	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q4G0F5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:Q9UBQ0-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VPS35	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Vps35	IPI	UniProtKB:Q5S006	Mouse	MGI:MGI:5784974\|PMID:23395371
Molecular Function	GO:0005515	protein binding	Vps35	IPI	UniProtKB:O88307\|UniProtKB:Q6PHU5	Mouse	MGI:MGI:3795652\|PMID:18480253
Molecular Function	GO:0005515	protein binding	Vps35	IPI	UniProtKB:Q5T9L3	Mouse	MGI:MGI:5693228\|PMID:18160348
Molecular Function	GO:0005515	protein binding	Vps35	IPI	UniProtKB:Q61616	Mouse	MGI:MGI:5796045\|PMID:27460146
Molecular Function	GO:0005515	protein binding	Vps35	IPI	UniProtKB:P40336-1\|UniProtKB:Q9QZ88-1	Mouse	MGI:MGI:5915260\|PMID:15965486
Molecular Function	GO:0005515	protein binding	Vps35	IPI	UniProtKB:Q6PHU5\|UniProtKB:Q9QZ88	Mouse	MGI:MGI:4867115\|PMID:21040701
Molecular Function	GO:0005515	protein binding	Vps35	IPI	UniProtKB:Q5T1M5\|UniProtKB:Q9QZ88	Mouse	MGI:MGI:5317099\|PMID:20923837
Molecular Function	GO:0005515	protein binding	Vps35	IPI	PR:Q62351	Mouse	PMID:23416069
Molecular Function	GO:0005515	protein binding	Vps35	IPI	PR:Q14B62	Mouse	PMID:29118110
Molecular Function	GO:0005515	protein binding	Vps35	IPI	PR:Q8BUV8	Mouse	PMID:24849652
Molecular Function	GO:0005515	protein binding	Vps35	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Cellular Component	GO:0005737	cytoplasm	Vps35	IDA		Mouse	MGI:MGI:5693230\|PMID:17239604
Cellular Component	GO:0005737	cytoplasm	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Cellular Component	GO:0005829	cytosol	VPS35	IDA		Human	PMID:11102511
Cellular Component	GO:0005829	cytosol	Vps35	IDA		Rat	PMID:11102511\|RGD:10412293
Cellular Component	GO:0098691	dopaminergic synapse	Vps35	IDA		Mouse	PMID:30155515
Cellular Component	GO:0098691	dopaminergic synapse	Vps35	IEP		Mouse	PMID:30155515
Cellular Component	GO:0098691	dopaminergic synapse	Vps35	IMP		Mouse	PMID:30155515
Cellular Component	GO:0005769	early endosome	VPS35	IDA		Human	PMID:18160348
Cellular Component	GO:0005769	early endosome	VPS35	IDA		Human	PMID:20164305
Cellular Component	GO:0005769	early endosome	VPS35	IDA		Human	PMID:27385586
Cellular Component	GO:0005768	endosome	VPS35	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005768	endosome	VPS35	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005768	endosome	VPS35	IDA		Human	PMID:15078903
Cellular Component	GO:0005768	endosome	VPS35	IDA		Human	PMID:28892079
Cellular Component	GO:0005768	endosome	Vps35	IDA		Mouse	PMID:26965651
Cellular Component	GO:0010008	endosome membrane	VPS35	IDA		Human	PMID:27385586
Cellular Component	GO:0070062	extracellular exosome	VPS35	HDA		Human	PMID:19056867
Cellular Component	GO:0098978	glutamatergic synapse	Vps35	IDA		Mouse	PMID:28384478
Cellular Component	GO:0098978	glutamatergic synapse	Vps35	IMP		Mouse	PMID:28384478
Cellular Component	GO:0098978	glutamatergic synapse	Vps35	IDA		Mouse	PMID:26521016
Cellular Component	GO:0098978	glutamatergic synapse	Vps35	IMP		Mouse	PMID:26521016
Cellular Component	GO:0098978	glutamatergic synapse	Vps35	IPI		Mouse	PMID:26521016
Cellular Component	GO:0098978	glutamatergic synapse	Vps35	IEP		Mouse	PMID:26521016
Cellular Component	GO:0005765	lysosomal membrane	VPS35	HDA		Human	PMID:17897319
Cellular Component	GO:0005764	lysosome	VPS35	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	VPS35	IDA		Human	PMID:26618722
Cellular Component	GO:0099073	mitochondrion-derived vesicle	VPS35	IDA		Human	PMID:26618722
Cellular Component	GO:0043005	neuron projection	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Cellular Component	GO:0043025	neuronal cell body	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Cellular Component	GO:0098794	postsynapse	Vps35	IEP		Mouse	PMID:26521016
Cellular Component	GO:0098794	postsynapse	Vps35	IDA		Mouse	PMID:26521016
Cellular Component	GO:0098794	postsynapse	Vps35	IPI		Mouse	PMID:26521016
Cellular Component	GO:0098794	postsynapse	Vps35	IMP		Mouse	PMID:26521016
Cellular Component	GO:0098794	postsynapse	Vps35	IDA		Mouse	PMID:29445238
Cellular Component	GO:0014069	postsynaptic density	Vps35	IDA		Mouse	PMID:17114649
Cellular Component	GO:0098793	presynapse	Vps35	IDA		Mouse	PMID:29445238
Cellular Component	GO:0030904	retromer complex	VPS35	IDA		Human	PMID:11102511
Cellular Component	GO:0030904	retromer complex	VPS35	IDA		Human	PMID:28892079
Cellular Component	GO:0030904	retromer complex	Vps35	IDA		Mouse	MGI:MGI:4867115\|PMID:21040701
Cellular Component	GO:0030904	retromer complex	Vps35	IDA		Rat	PMID:11102511\|RGD:10412293
Cellular Component	GO:0030906	retromer, cargo-selective complex	VPS35	IDA		Human	PMID:20164305
Cellular Component	GO:0030906	retromer, cargo-selective complex	VPS35	IDA		Human	PMID:27385586
Cellular Component	GO:0045202	synapse	Vps35	IDA		Mouse	PMID:29118110
Cellular Component	GO:0097422	tubular endosome	VPS35	IDA		Human	PMID:15078903
Biological Process	GO:0032456	endocytic recycling	VPS35	IMP		Human	PMID:20164305
Biological Process	GO:0032456	endocytic recycling	VPS35	IMP		Human	PMID:21602791
Biological Process	GO:0007040	lysosome organization	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	VPS35	IMP		Human	PMID:26618722
Biological Process	GO:0099074	mitochondrion to lysosome transport	VPS35	IMP		Human	PMID:26618722
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Vps35	IDA		Mouse	PMID:30155515
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Vps35	IEP		Mouse	PMID:30155515
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Vps35	IMP		Mouse	PMID:30155515
Biological Process	GO:0060548	negative regulation of cell death	VPS35	IGI	UniProtKB:P34110,UniProtKB:Q04637	Human	PMID:25533483
Biological Process	GO:0010629	negative regulation of gene expression	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:0050728	negative regulation of inflammatory response	VPS35	IGI	UniProtKB:P37840	Human	PMID:25533483
Biological Process	GO:1902823	negative regulation of late endosome to lysosome transport	VPS35	IMP		Human	PMID:23563491
Biological Process	GO:1905166	negative regulation of lysosomal protein catabolic process	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:1901215	negative regulation of neuron death	VPS35	IGI	UniProtKB:P37840	Human	PMID:25533483
Biological Process	GO:1901215	negative regulation of neuron death	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:0032463	negative regulation of protein homooligomerization	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:1903828	negative regulation of protein localization	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:0099639	neurotransmitter receptor transport, endosome to plasma membrane	VPS35	IDA		Human	PMID:27460146
Biological Process	GO:0099639	neurotransmitter receptor transport, endosome to plasma membrane	Vps35	IMP		Mouse	MGI:MGI:5796045\|PMID:27460146
Biological Process	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	Vps35	IDA		Mouse	PMID:28384478
Biological Process	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	Vps35	IMP		Mouse	PMID:28384478
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Vps35	IGI	UniProtKB:P04426	Mouse	MGI:MGI:5693230\|PMID:17239604
Biological Process	GO:1903181	positive regulation of dopamine biosynthetic process	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:0060161	positive regulation of dopamine receptor signaling pathway	VPS35	IDA		Human	PMID:27460146
Biological Process	GO:0010628	positive regulation of gene expression	VPS35	IDA		Human	PMID:26618722
Biological Process	GO:0010628	positive regulation of gene expression	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:0090326	positive regulation of locomotion involved in locomotory behavior	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:0090141	positive regulation of mitochondrial fission	VPS35	IMP		Human	PMID:26618722
Biological Process	GO:0045732	positive regulation of protein catabolic process	VPS35	IGI	UniProtKB:P37840	Human	PMID:25533483
Biological Process	GO:0061357	positive regulation of Wnt protein secretion	Vps35	IMP		Mouse	MGI:MGI:5693228\|PMID:18160348
Biological Process	GO:0031648	protein destabilization	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:0036010	protein localization to endosome	VPS35	IMP		Human	PMID:28892079
Biological Process	GO:0033365	protein localization to organelle	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154
Biological Process	GO:1902950	regulation of dendritic spine maintenance	VPS35	IMP		Human	PMID:26618722
Biological Process	GO:0010821	regulation of mitochondrion organization	VPS35	IGI	UniProtKB:B1WBS4,UniProtKB:Q6AY86	Human	PMID:26618722
Biological Process	GO:0150052	regulation of postsynapse assembly	Vps35	IMP		Mouse	PMID:26521016
Biological Process	GO:0150052	regulation of postsynapse assembly	Vps35	IDA		Mouse	PMID:26521016
Biological Process	GO:0051246	regulation of protein metabolic process	VPS35	IGI	UniProtKB:P39935	Human	PMID:25533483
Biological Process	GO:0051246	regulation of protein metabolic process	VPS35	IDA		Human	PMID:26618722
Biological Process	GO:0031647	regulation of protein stability	VPS35	IMP		Human	PMID:18193037
Biological Process	GO:0090128	regulation of synapse maturation	Vps35	IMP		Mouse	PMID:26521016
Biological Process	GO:0090128	regulation of synapse maturation	Vps35	IDA		Mouse	PMID:26521016
Biological Process	GO:2000331	regulation of terminal button organization	VPS35	IMP		Human	PMID:26618722
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	VPS35	IMP		Human	PMID:15078903
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	VPS35	IMP		Human	PMID:26618722
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	VPS35	IMP		Human	PMID:27385586
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	Vps35	IMP		Rat	PMID:23395371\|RGD:8553873
Biological Process	GO:0045056	transcytosis	VPS35	IDA		Human	PMID:15247922
Biological Process	GO:0099003	vesicle-mediated transport in synapse	Vps35	IDA		Mouse	PMID:28384478
Biological Process	GO:0099003	vesicle-mediated transport in synapse	Vps35	IMP		Mouse	PMID:28384478
Biological Process	GO:0050882	voluntary musculoskeletal movement	Vps35	IMP		Mouse	MGI:MGI:5694519\|PMID:26203154

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.