Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VPS4A
  • Mouse genes Vps4a
  • Rat genes Vps4a
  • Zfish genes vps4a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vps4a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	VPS4A	IMP		Human	PMID:10637304
Molecular Function	GO:0016887	ATP hydrolysis activity	VPS4A	IMP		Human	PMID:10637304
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9HD42	Human	PMID:11559748
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:O75351	Human	PMID:11563910
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:O43633	Human	PMID:14505570
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q7LBR1	Human	PMID:14505570
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q96CF2	Human	PMID:14505570
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9BY43	Human	PMID:14505570
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9HD42	Human	PMID:14505570
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:O43633	Human	PMID:14519844
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q7LBR1	Human	PMID:14519844
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9HD42	Human	PMID:14519844
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q7LBR1	Human	PMID:16174732
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:O43633	Human	PMID:16730941
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q7LBR1	Human	PMID:16730941
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9HD42	Human	PMID:16730941
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:O43633	Human	PMID:17928862
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q7LBR1	Human	PMID:17928862
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9HD42	Human	PMID:17928862
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9HD42-1	Human	PMID:17928862
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9UQN3	Human	PMID:17928862
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9NP79	Human	PMID:18385515
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q96FZ7	Human	PMID:18606141
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q7LBR1	Human	PMID:18997780
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:P53990	Human	PMID:19129479
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:P53843	Human	PMID:19129480
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:P53990	Human	PMID:19129480
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:O43633	Human	PMID:21543490
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q7LBR1	Human	PMID:21543490
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q96FZ7	Human	PMID:21543490
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9H444	Human	PMID:21543490
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9Y3E7	Human	PMID:21543490
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q9NP79	Human	PMID:23105106
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q96K21	Human	PMID:24814515
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:Q96K21-1	Human	PMID:24814515
Molecular Function	GO:0005515	protein binding	VPS4A	IPI	UniProtKB:O95833	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Vps4a	IPI	UniProtKB:P46467	Mouse	MGI:MGI:2651946|PMID:12594041
Molecular Function	GO:0044877	protein-containing complex binding	VPS4A	IPI	ComplexPortal:CPX-329	Human	PMID:18606141
Molecular Function	GO:0031267	small GTPase binding	Vps4a	IPI	RGD:1306172	Rat	PMID:11931639|RGD:2290289
Cellular Component	GO:0005813	centrosome	VPS4A	IDA		Human	PMID:20616062
Cellular Component	GO:0005737	cytoplasm	VPS4A	IDA		Human	PMID:11563910
Cellular Component	GO:0005737	cytoplasm	VPS4A	IDA		Human	PMID:15075231
Cellular Component	GO:0005737	cytoplasm	VPS4A	IDA		Human	PMID:20616062
Cellular Component	GO:0005737	cytoplasm	Vps4a	IDA		Mouse	MGI:MGI:2651946|PMID:12594041
Cellular Component	GO:0005829	cytosol	VPS4A	IDA		Human	PMID:10637304
Cellular Component	GO:0005769	early endosome	VPS4A	IDA		Human	PMID:10637304
Cellular Component	GO:0005769	early endosome	VPS4A	IDA		Human	PMID:15075231
Cellular Component	GO:0005769	early endosome	Vps4a	IDA		Rat	PMID:11931639|RGD:2290289
Cellular Component	GO:0005768	endosome	VPS4A	IDA		Human	PMID:17940959
Cellular Component	GO:0010008	endosome membrane	VPS4A	IMP		Human	PMID:18606141
Cellular Component	GO:0070062	extracellular exosome	VPS4A	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	VPS4A	HDA		Human	PMID:23533145
Cellular Component	GO:0090543	Flemming body	VPS4A	IDA		Human	PMID:20616062
Cellular Component	GO:0005770	late endosome	VPS4A	IDA		Human	PMID:10637304
Cellular Component	GO:0005770	late endosome	VPS4A	IDA		Human	PMID:15075231
Cellular Component	GO:0005764	lysosome	VPS4A	IDA		Human	PMID:10637304
Cellular Component	GO:0030496	midbody	VPS4A	IDA		Human	PMID:17853893
Cellular Component	GO:0030496	midbody	VPS4A	IDA		Human	PMID:19129479
Cellular Component	GO:0030496	midbody	VPS4A	IDA		Human	PMID:24814515
Cellular Component	GO:0005634	nucleus	VPS4A	IDA		Human	PMID:20616062
Cellular Component	GO:0048471	perinuclear region of cytoplasm	VPS4A	IDA		Human	PMID:11563910
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Vps4a	IDA		Mouse	MGI:MGI:2651946|PMID:12594041
Cellular Component	GO:0005886	plasma membrane	VPS4A	IDA		Human	PMID:17940959
Cellular Component	GO:0000922	spindle pole	VPS4A	IDA		Human	PMID:20616062
Cellular Component	GO:0005774	vacuolar membrane	VPS4A	IDA		Human	PMID:10637304
Biological Process	GO:0009838	abscission	VPS4A	IMP		Human	PMID:24814515
Biological Process	GO:0051301	cell division	VPS4A	IDA		Human	PMID:17853893
Biological Process	GO:0016197	endosomal transport	VPS4A	IMP		Human	PMID:10637304
Biological Process	GO:0016197	endosomal transport	VPS4A	IMP		Human	PMID:11559748
Biological Process	GO:0034058	endosomal vesicle fusion	VPS4A	IMP		Human	PMID:15075231
Biological Process	GO:0032367	intracellular cholesterol transport	VPS4A	IMP		Human	PMID:10637304
Biological Process	GO:0061738	late endosomal microautophagy	Vps4a	IMP		Mouse	MGI:MGI:5700294|PMID:21238931
Biological Process	GO:0061952	midbody abscission	VPS4A	IMP		Human	PMID:20616062
Biological Process	GO:0044878	mitotic cytokinesis checkpoint signaling	VPS4A	IMP		Human	PMID:24814515
Biological Process	GO:0007080	mitotic metaphase plate congression	VPS4A	IMP		Human	PMID:20616062
Biological Process	GO:0036258	multivesicular body assembly	Vps4a	IMP		Mouse	MGI:MGI:5700294|PMID:21238931
Biological Process	GO:0032466	negative regulation of cytokinesis	VPS4A	IMP		Human	PMID:24814515
Biological Process	GO:0006997	nucleus organization	VPS4A	IMP		Human	PMID:20616062
Biological Process	GO:1903543	positive regulation of exosomal secretion	VPS4A	IMP	UniProtKB:O75351	Human	PMID:22660413
Biological Process	GO:1903774	positive regulation of viral budding via host ESCRT complex	VPS4A	IMP		Human	PMID:24878737
Biological Process	GO:0006622	protein targeting to lysosome	VPS4A	IMP		Human	PMID:16973552
Biological Process	GO:0032880	regulation of protein localization	VPS4A	IMP		Human	PMID:18005716
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	VPS4A	IMP		Human	PMID:24878737
Biological Process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	VPS4A	IMP		Human	PMID:22547407
Biological Process	GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway	VPS4A	IMP		Human	PMID:22547407
Biological Process	GO:0006900	vesicle budding from membrane	VPS4A	IMP		Human	PMID:15075231
Biological Process	GO:0072319	vesicle uncoating	VPS4A	IMP		Human	PMID:15075231
Biological Process	GO:0016192	vesicle-mediated transport	VPS4A	IDA		Human	PMID:11563910
Biological Process	GO:0046761	viral budding from plasma membrane	VPS4A	IMP		Human	PMID:16193069
Biological Process	GO:0046761	viral budding from plasma membrane	VPS4A	IMP		Human	PMID:17940959
Biological Process	GO:0046761	viral budding from plasma membrane	Vps4a	IMP		Mouse	MGI:MGI:5619479|PMID:17940959
Biological Process	GO:0039702	viral budding via host ESCRT complex	VPS4A	IGI	UniProtKB:O75351	Human	PMID:24107264
Biological Process	GO:0019076	viral release from host cell	VPS4A	IMP		Human	PMID:11595185

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern