Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VPS4B
  • Mouse genes Vps4b
  • Rat genes Vps4b
  • Zfish genes vps4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vps4b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016887	ATP hydrolysis activity	VPS4B	IDA		Human	PMID:11563910
Molecular Function	GO:0016887	ATP hydrolysis activity	VPS4B	IDA		Human	PMID:18687924
Molecular Function	GO:0042802	identical protein binding	VPS4B	IDA		Human	PMID:16193069
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9UN37	Human	PMID:11563910
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:O43633	Human	PMID:14505570
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9HD42	Human	PMID:14505570
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9NP79	Human	PMID:16193069
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:O15118	Human	PMID:16757520
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:O43633	Human	PMID:17928862
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q7LBR1	Human	PMID:17928862
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9HD42	Human	PMID:17928862
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9UQN3	Human	PMID:17928862
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9UQN3-1	Human	PMID:17928862
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9NP79	Human	PMID:18385515
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:O43633	Human	PMID:18687924
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9Y3E7	Human	PMID:18687924
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:P53990	Human	PMID:19129479
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9NP79	Human	PMID:23105106
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q96K21	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q96K21-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9NZZ3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q96K21	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q96K21	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9BW62	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9HD42	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:Q9NZZ3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS4B	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Vps4b	IPI	UniProtKB:Q8VEJ9	Mouse	MGI:MGI:2651946|PMID:12594041
Molecular Function	GO:0005515	protein binding	Vps4b	IPI	PR:Q9CR26	Mouse	PMID:15173323
Molecular Function	GO:0005515	protein binding	Vps4b	IPI	PR:Q9DB34	Mouse	PMID:15173323
Molecular Function	GO:0042803	protein homodimerization activity	VPS4B	IDA		Human	PMID:16193069
Molecular Function	GO:0044877	protein-containing complex binding	VPS4B	IDA		Human	PMID:18687924
Cellular Component	GO:0005813	centrosome	VPS4B	IDA		Human	PMID:20616062
Cellular Component	GO:0005737	cytoplasm	VPS4B	IDA		Human	PMID:16757520
Cellular Component	GO:0005737	cytoplasm	VPS4B	IDA		Human	PMID:20616062
Cellular Component	GO:0005829	cytosol	Vps4b	IDA		Mouse	PMID:10637304
Cellular Component	GO:0005829	cytosol	Vps4b	IDA		Mouse	PMID:16757520
Cellular Component	GO:0005829	cytosol	Vps4b	IDA		Mouse	PMID:15173323
Cellular Component	GO:0005768	endosome	VPS4B	IDA		Human	PMID:11563910
Cellular Component	GO:0010008	endosome membrane	VPS4B	IDA		Human	PMID:16757520
Cellular Component	GO:0070062	extracellular exosome	VPS4B	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	VPS4B	HDA		Human	PMID:23533145
Cellular Component	GO:0090543	Flemming body	VPS4B	IDA		Human	PMID:20616062
Cellular Component	GO:0005634	nucleus	VPS4B	IDA		Human	PMID:16757520
Cellular Component	GO:0005634	nucleus	VPS4B	IDA		Human	PMID:20616062
Cellular Component	GO:0000922	spindle pole	VPS4B	IDA		Human	PMID:20616062
Biological Process	GO:0001525	angiogenesis	Vps4b	IMP		Mouse	PMID:28675177
Biological Process	GO:0060070	canonical Wnt signaling pathway	Vps4b	IMP		Mouse	PMID:28675177
Biological Process	GO:0007417	central nervous system development	Vps4b	IMP		Mouse	PMID:28675177
Biological Process	GO:0030301	cholesterol transport	Vps4b	IMP		Mouse	PMID:10637304
Biological Process	GO:0016197	endosomal transport	VPS4B	IDA		Human	PMID:11563910
Biological Process	GO:0007032	endosome organization	Vps4b	IMP		Mouse	PMID:10637304
Biological Process	GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway	VPS4B	IMP		Human	PMID:15024011
Biological Process	GO:1904903	ESCRT III complex disassembly	VPS4B	IDA		Human	PMID:18687924
Biological Process	GO:0060856	establishment of blood-brain barrier	Vps4b	IMP		Mouse	PMID:28675177
Biological Process	GO:0061738	late endosomal microautophagy	Vps4b	IMP		Mouse	MGI:MGI:5700294|PMID:21238931
Biological Process	GO:0061952	midbody abscission	VPS4B	IMP		Human	PMID:20616062
Biological Process	GO:0007080	mitotic metaphase plate congression	VPS4B	IMP		Human	PMID:20616062
Biological Process	GO:0036258	multivesicular body assembly	Vps4b	IMP		Mouse	MGI:MGI:5700294|PMID:21238931
Biological Process	GO:0060548	negative regulation of cell death	VPS4B	IMP		Human	PMID:20616062
Biological Process	GO:1903542	negative regulation of exosomal secretion	VPS4B	IMP		Human	PMID:24105262
Biological Process	GO:0006997	nucleus organization	VPS4B	IMP		Human	PMID:20616062
Biological Process	GO:0042476	odontogenesis	vps4b	IMP	ZFIN:ZDB-MRPHLNO-161107-5	Zfish	PMID:27247351
Biological Process	GO:0042476	odontogenesis	vps4b	IMP	ZFIN:ZDB-MRPHLNO-161107-6	Zfish	PMID:27247351
Biological Process	GO:1903724	positive regulation of centriole elongation	VPS4B	IMP		Human	PMID:20616062
Biological Process	GO:1903543	positive regulation of exosomal secretion	VPS4B	IMP	UniProtKB:Q9UN37	Human	PMID:22660413
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	VPS4B	IMP		Human	PMID:20616062
Biological Process	GO:0006813	potassium ion transport	Vps4b	IDA		Mouse	PMID:8082782
Biological Process	GO:0051261	protein depolymerization	VPS4B	IDA		Human	PMID:18687924
Biological Process	GO:0010824	regulation of centrosome duplication	VPS4B	IMP		Human	PMID:20616062
Biological Process	GO:1901673	regulation of mitotic spindle assembly	VPS4B	IMP		Human	PMID:20616062
Biological Process	GO:0033993	response to lipid	VPS4B	IDA		Human	PMID:16757520
Biological Process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	VPS4B	IMP		Human	PMID:22547407
Biological Process	GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway	VPS4B	IMP		Human	PMID:22547407
Biological Process	GO:0007034	vacuolar transport	Vps4b	IMP		Mouse	PMID:28675177
Biological Process	GO:0046761	viral budding from plasma membrane	VPS4B	IMP		Human	PMID:14505570
Biological Process	GO:0046761	viral budding from plasma membrane	VPS4B	IMP		Human	PMID:16193069
Biological Process	GO:0046761	viral budding from plasma membrane	VPS4B	IMP		Human	PMID:17940959
Biological Process	GO:0046761	viral budding from plasma membrane	Vps4b	IMP		Mouse	MGI:MGI:5619479|PMID:17940959
Biological Process	GO:0039702	viral budding via host ESCRT complex	VPS4B	IGI	UniProtKB:Q9UN37	Human	PMID:24107264

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern