Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VRK2
  • Mouse genes Vrk2
  • Rat genes Vrk2
  • Zfish genes vrk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vrk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:P03182	Human	PMID:16963744
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:Q02750	Human	PMID:20679487
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:Q8IVT5	Human	PMID:20679487
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:Q8IVT5	Human	PMID:22752157
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:P36382	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:Q0VAB0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:Q6PEY1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:Q6UW68	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:Q8N4V1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VRK2	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0019904	protein domain specific binding	VRK2	IDA		Human	PMID:22572157
Molecular Function	GO:0019901	protein kinase binding	VRK2	IDA		Human	PMID:22572157
Molecular Function	GO:0004674	protein serine/threonine kinase activity	VRK2	IDA		Human	PMID:14645249
Molecular Function	GO:0004674	protein serine/threonine kinase activity	VRK2	IDA		Human	PMID:16495336
Molecular Function	GO:0004674	protein serine/threonine kinase activity	VRK2	IDA		Human	PMID:16704422
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Vrk2	IDA		Mouse	PMID:14645249
Cellular Component	GO:0005737	cytoplasm	VRK2	IDA		Human	PMID:16704422
Cellular Component	GO:0005783	endoplasmic reticulum	VRK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	VRK2	IDA		Human	PMID:22572157
Cellular Component	GO:0005783	endoplasmic reticulum	Vrk2	IDA		Mouse	MGI:MGI:6316504|PMID:31142202
Cellular Component	GO:0005783	endoplasmic reticulum	Vrk2	IDA		Mouse	PMID:14645249
Cellular Component	GO:0005789	endoplasmic reticulum membrane	VRK2	IDA		Human	PMID:18286207
Cellular Component	GO:0016020	membrane	Vrk2	IDA		Mouse	PMID:14645249
Cellular Component	GO:0031966	mitochondrial membrane	VRK2	IDA		Human	PMID:18286207
Cellular Component	GO:0005635	nuclear envelope	Vrk2	IDA		Mouse	MGI:MGI:6316504|PMID:31142202
Cellular Component	GO:0005634	nucleus	VRK2	IDA		Human	PMID:16704422
Cellular Component	GO:0032991	protein-containing complex	VRK2	IDA		Human	PMID:22572157
Biological Process	GO:0002118	aggressive behavior	vrk2	IMP	ZFIN:ZDB-GENO-221207-1	Zfish	PMID:35094457
Biological Process	GO:0034599	cellular response to oxidative stress	VRK2	IMP		Human	PMID:17709393
Biological Process	GO:0046777	protein autophosphorylation	VRK2	IDA		Human	PMID:14645249
Biological Process	GO:0046777	protein autophosphorylation	VRK2	IDA		Human	PMID:16704422
Biological Process	GO:0046777	protein autophosphorylation	Vrk2	IDA		Mouse	PMID:14645249
Biological Process	GO:0006468	protein phosphorylation	Vrk2	IDA		Mouse	PMID:14645249
Biological Process	GO:2000659	regulation of interleukin-1-mediated signaling pathway	VRK2	IMP		Human	PMID:18286207
Biological Process	GO:0043408	regulation of MAPK cascade	VRK2	IMP		Human	PMID:20679487
Biological Process	GO:0035176	social behavior	vrk2	IMP	ZFIN:ZDB-GENO-221207-1	Zfish	PMID:35094457

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern