Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VWF
  • Mouse genes Vwf
  • Rat genes Vwf
  • Zfish genes vwf
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vwf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	VWF	IDA		Human	PMID:2056120
Molecular Function	GO:0042802	identical protein binding	VWF	IPI	UniProtKB:P04275	Human	PMID:10887119
Molecular Function	GO:0042802	identical protein binding	VWF	IPI	UniProtKB:P04275	Human	PMID:16409464
Molecular Function	GO:0042802	identical protein binding	VWF	IPI	UniProtKB:P04275	Human	PMID:17895385
Molecular Function	GO:0042802	identical protein binding	VWF	IPI	UniProtKB:P04275	Human	PMID:18182488
Molecular Function	GO:0042802	identical protein binding	VWF	IPI	UniProtKB:P04275	Human	PMID:18492805
Molecular Function	GO:0042802	identical protein binding	VWF	IPI	UniProtKB:P04275	Human	PMID:21857647
Molecular Function	GO:0019865	immunoglobulin binding	VWF	IDA		Human	PMID:3121636
Molecular Function	GO:0005178	integrin binding	VWF	IPI	UniProtKB:P13612	Human	PMID:9079671
Molecular Function	GO:0002020	protease binding	VWF	IPI	UniProtKB:Q76LX8	Human	PMID:12775718
Molecular Function	GO:0002020	protease binding	VWF	IDA		Human	PMID:15824096
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:P13224	Human	PMID:11943773
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:P07359	Human	PMID:12183630
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:P07359	Human	PMID:15039442
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:Q76LX8	Human	PMID:16221672
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:P02461	Human	PMID:16912226
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:P00451	Human	PMID:18492805
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:Q76LX8	Human	PMID:18492805
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:Q76LX8	Human	PMID:25512528
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:P00451	Human	PMID:27749002
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:P02461	Human	PMID:2839553
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:P07359	Human	PMID:7721887
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:P00451	Human	PMID:7756647
Molecular Function	GO:0005515	protein binding	VWF	IPI	UniProtKB:P00451:PRO_0000002967	Human	PMID:8562925
Molecular Function	GO:0005515	protein binding	Vwf	IPI	PR:P55002	Mouse	PMID:18281502
Molecular Function	GO:0051087	protein-folding chaperone binding	VWF	IDA		Human	PMID:10887119
Cellular Component	GO:0062023	collagen-containing extracellular matrix	VWF	HDA		Human	PMID:23979707
Cellular Component	GO:0062023	collagen-containing extracellular matrix	VWF	IDA		Human	PMID:6754744
Cellular Component	GO:0062023	collagen-containing extracellular matrix	VWF	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	VWF	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Vwf	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Vwf	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Vwf	IDA		Rat	PMID:14762664|RGD:1599021
Cellular Component	GO:0005737	cytoplasm	Vwf	IDA		Rat	PMID:8811296|RGD:11079207
Cellular Component	GO:0005783	endoplasmic reticulum	VWF	IDA		Human	PMID:6754744
Cellular Component	GO:0005783	endoplasmic reticulum	Vwf	IDA		Rat	PMID:2650559|RGD:11079230
Cellular Component	GO:0009897	external side of plasma membrane	Vwf	IDA		Mouse	PMID:8562500
Cellular Component	GO:0070062	extracellular exosome	VWF	HDA		Human	PMID:19056867
Cellular Component	GO:0005576	extracellular region	VWF	IDA		Human	PMID:10887119
Cellular Component	GO:0005576	extracellular region	VWF	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	Vwf	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Vwf	IDA		Mouse	PMID:30573509
Cellular Component	GO:0005615	extracellular space	Vwf	IDA		Rat	PMID:12217600|RGD:727737
Cellular Component	GO:0033093	Weibel-Palade body	VWF	IDA		Human	PMID:3082891
Cellular Component	GO:0033093	Weibel-Palade body	VWF	IDA		Human	PMID:3087627
Cellular Component	GO:0033093	Weibel-Palade body	Vwf	IDA		Mouse	PMID:30573509
Biological Process	GO:0002543	activation of blood coagulation via clotting cascade	Vwf	IDA		Mouse	PMID:30573509
Biological Process	GO:0007596	blood coagulation	VWF	IMP		Human	PMID:16409464
Biological Process	GO:0007596	blood coagulation	Vwf	IMP	MGI:MGI:2153009	Mouse	PMID:17380206
Biological Process	GO:0007596	blood coagulation	Vwf	IMP	MGI:MGI:2153009	Mouse	PMID:21037087
Biological Process	GO:0007596	blood coagulation	Vwf	IMP	MGI:MGI:2153009	Mouse	PMID:9689113
Biological Process	GO:0007596	blood coagulation	Vwf	IMP		Rat	PMID:10709908|RGD:1599012
Biological Process	GO:0007596	blood coagulation	Vwf	IMP		Rat	PMID:9504130|RGD:1599016
Biological Process	GO:0007155	cell adhesion	VWF	IDA		Human	PMID:10764791
Biological Process	GO:0031589	cell-substrate adhesion	VWF	IDA		Human	PMID:9079671
Biological Process	GO:0031589	cell-substrate adhesion	Vwf	IMP	MGI:MGI:2153009	Mouse	PMID:11071623
Biological Process	GO:0070417	cellular response to cold	Vwf	IEP		Rat	PMID:12084999|RGD:11079231
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Vwf	IEP		Rat	PMID:17708840|RGD:11079229
Biological Process	GO:0007599	hemostasis	VWF	IMP		Human	PMID:10887119
Biological Process	GO:0007599	hemostasis	Vwf	IMP	MGI:MGI:2153009	Mouse	PMID:9689113
Biological Process	GO:0007599	hemostasis	vwf	IMP	ZFIN:ZDB-MRPHLNO-110818-1	Zfish	PMID:21035359
Biological Process	GO:0006954	inflammatory response	Vwf	IDA		Mouse	PMID:30573509
Biological Process	GO:0001889	liver development	Vwf	IMP	MGI:MGI:1857656	Mouse	PMID:7854452
Biological Process	GO:0097421	liver regeneration	Vwf	IEP		Rat	PMID:12217600|RGD:727737
Biological Process	GO:0001890	placenta development	Vwf	IMP	MGI:MGI:1857656	Mouse	PMID:7854452
Biological Process	GO:0030168	platelet activation	VWF	IDA		Human	PMID:8565074
Biological Process	GO:0030168	platelet activation	Vwf	IMP	MGI:MGI:2153009	Mouse	PMID:10930441
Biological Process	GO:0030168	platelet activation	Vwf	IMP	MGI:MGI:2153009	Mouse	PMID:21037087
Biological Process	GO:0030168	platelet activation	Vwf	IMP		Rat	PMID:10709908|RGD:1599012
Biological Process	GO:0030168	platelet activation	Vwf	IMP		Rat	PMID:9504130|RGD:1599016
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	VWF	IDA		Human	PMID:14656219
Biological Process	GO:0035902	response to immobilization stress	Vwf	IEP		Rat	PMID:14566072|RGD:1625713
Biological Process	GO:0033591	response to L-ascorbic acid	Vwf	IEP		Rat	PMID:14737039|RGD:1601646
Biological Process	GO:0010165	response to X-ray	Vwf	IEP		Rat	PMID:8811296|RGD:11079207

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern