Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WAPL
  • Mouse genes Wapl
  • Rat genes Wapl
  • Zfish genes wapla,waplb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wapl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140083	ATP-dependent protein-DNA unloader activity	WAPL	IMP		Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:O60216	Human	PMID:17112726
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q8N3U4	Human	PMID:17112726
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q9NTI5	Human	PMID:17112726
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:O60216	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q29RF7	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q8N3U4	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q9NTI5	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:O60216	Human	PMID:19696148
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q9UQE7	Human	PMID:19907496
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:O60216	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q8N3U4	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q9NTI5	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q29RF7	Human	PMID:21111234
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:O60216	Human	PMID:25173175
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q8N3U4	Human	PMID:25173175
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:O60216	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q8N3U4	Human	PMID:29263825
Molecular Function	GO:0005515	protein binding	WAPL	IPI	UniProtKB:Q8N3U4	Human	PMID:29867216
Cellular Component	GO:0000785	chromatin	WAPL	IDA		Human	PMID:17113138
Cellular Component	GO:0000785	chromatin	WAPL	IDA		Human	PMID:19696148
Cellular Component	GO:0005737	cytoplasm	WAPL	IDA		Human	PMID:17113138
Cellular Component	GO:0005737	cytoplasm	WAPL	IDA		Human	PMID:19696148
Cellular Component	GO:0005829	cytosol	WAPL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045171	intercellular bridge	WAPL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	WAPL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072686	mitotic spindle	WAPL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	WAPL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	WAPL	IDA		Human	PMID:17113138
Cellular Component	GO:0005634	nucleus	WAPL	IDA		Human	PMID:19696148
Biological Process	GO:0000070	mitotic sister chromatid segregation	WAPL	IMP		Human	PMID:17113138
Biological Process	GO:0035562	negative regulation of chromatin binding	WAPL	IMP		Human	PMID:17113138
Biological Process	GO:0035562	negative regulation of chromatin binding	WAPL	IMP		Human	PMID:19696148
Biological Process	GO:0008156	negative regulation of DNA replication	WAPL	IMP		Human	PMID:19907496
Biological Process	GO:0045875	negative regulation of sister chromatid cohesion	WAPL	IMP		Human	PMID:19696148
Biological Process	GO:0045875	negative regulation of sister chromatid cohesion	WAPL	IMP		Human	PMID:21111234
Biological Process	GO:0071168	protein localization to chromatin	WAPL	IMP		Human	PMID:21111234

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern