Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WAS
  • Mouse genes Was
  • Rat genes Was
  • Zfish genes wasa,wasb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Was

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	WAS	IPI	UniProtKB:P42768	Human	PMID:10724160
Molecular Function	GO:0042802	identical protein binding	WAS	IPI	UniProtKB:P42768	Human	PMID:12769847
Molecular Function	GO:0042802	identical protein binding	WAS	IPI	UniProtKB:P42768	Human	PMID:18650809
Molecular Function	GO:0042802	identical protein binding	Was	IDA		Mouse	PMID:12147689
Molecular Function	GO:0043274	phospholipase binding	WAS	IPI	UniProtKB:P19174	Human	PMID:8892607
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43516	Human	PMID:10202051
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P08631	Human	PMID:12029088
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P08103	Human	PMID:12235133
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43516	Human	PMID:12591280
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:Q14247	Human	PMID:15169891
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P60953	Human	PMID:15361624
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43516	Human	PMID:16488394
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43516	Human	PMID:17213309
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:Q9Y5X1	Human	PMID:17242350
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P0DJ88	Human	PMID:18650809
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P08631	Human	PMID:19234535
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:Q8WV41	Human	PMID:19487689
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:Q9Y5X1	Human	PMID:19487689
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43516	Human	PMID:19805221
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43516	Human	PMID:19817875
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P60953	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:Q9P2A4	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43516	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P60953	Human	PMID:22252508
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43516	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43639	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O94875	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:Q92624	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:Q9P2A4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P60953	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P11387	Human	PMID:29248492
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P60953	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43516-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P57075-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:Q06187	Human	PMID:8892607
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:O43516	Human	PMID:9405671
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P60953	Human	PMID:9422512
Molecular Function	GO:0005515	protein binding	WAS	IPI	UniProtKB:P60953	Human	PMID:9660763
Molecular Function	GO:0005515	protein binding	Was	IPI	UniProtKB:Q9ER71	Mouse	MGI:MGI:1927282|PMID:10967094
Molecular Function	GO:0005515	protein binding	Was	IPI	UniProtKB:Q8BKC5|UniProtKB:Q8K1I7	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Was	IPI	UniProtKB:Q3USJ8	Mouse	MGI:MGI:6233193|PMID:23437151
Molecular Function	GO:0005515	protein binding	Was	IPI	UniProtKB:P05480	Mouse	MGI:MGI:4834990|PMID:18289379
Molecular Function	GO:0005515	protein binding	Was	IPI	PR:P43404	Mouse	PMID:15699074
Molecular Function	GO:0005515	protein binding	Was	IPI	PR:P06240	Mouse	PMID:15699074
Molecular Function	GO:0005515	protein binding	Was	IPI	PR:Q811D0	Mouse	PMID:15699074
Molecular Function	GO:0019901	protein kinase binding	WAS	IPI	UniProtKB:P42680	Human	PMID:8892607
Molecular Function	GO:0019901	protein kinase binding	WAS	IPI	UniProtKB:Q06187	Human	PMID:8892607
Molecular Function	GO:0019901	protein kinase binding	WAS	IPI	UniProtKB:Q08881	Human	PMID:8892607
Molecular Function	GO:0017124	SH3 domain binding	WAS	IPI	UniProtKB:Q19253	Human	PMID:19798448
Molecular Function	GO:0017124	SH3 domain binding	WAS	IPI	UniProtKB:Q5T0N5	Human	PMID:19798448
Molecular Function	GO:0017124	SH3 domain binding	WAS	IPI	UniProtKB:Q9XUS7	Human	PMID:19798448
Molecular Function	GO:0017124	SH3 domain binding	WAS	IPI	UniProtKB:P19174	Human	PMID:8892607
Molecular Function	GO:0017124	SH3 domain binding	WAS	IPI	UniProtKB:P42680	Human	PMID:8892607
Molecular Function	GO:0017124	SH3 domain binding	WAS	IPI	UniProtKB:P62993	Human	PMID:8892607
Molecular Function	GO:0017124	SH3 domain binding	WAS	IPI	UniProtKB:Q06187	Human	PMID:8892607
Molecular Function	GO:0017124	SH3 domain binding	WAS	IPI	UniProtKB:Q08881	Human	PMID:8892607
Molecular Function	GO:0031267	small GTPase binding	WAS	IPI	UniProtKB:P60953	Human	PMID:10724160
Molecular Function	GO:0031267	small GTPase binding	WAS	IPI	UniProtKB:P60953	Human	PMID:8625410
Molecular Function	GO:0031267	small GTPase binding	WAS	IPI	UniProtKB:P63000	Human	PMID:8625410
Cellular Component	GO:0005884	actin filament	WAS	IDA		Human	PMID:8625410
Cellular Component	GO:0005911	cell-cell junction	Was	IDA		Mouse	PMID:23793062
Cellular Component	GO:0005829	cytosol	WAS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	WAS	IDA		Human	PMID:8625410
Cellular Component	GO:0070062	extracellular exosome	WAS	HDA		Human	PMID:20458337
Cellular Component	GO:0005634	nucleus	WAS	IDA		Human	PMID:20574068
Cellular Component	GO:0005634	nucleus	WAS	IDA		Human	PMID:29925947
Cellular Component	GO:0045335	phagocytic vesicle	Was	IDA		Mouse	PMID:19144319
Cellular Component	GO:0005886	plasma membrane	WAS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0035861	site of double-strand break	WAS	IDA		Human	PMID:29925947
Cellular Component	GO:0012506	vesicle membrane	Was	IDA		Mouse	PMID:12147689
Biological Process	GO:0030041	actin filament polymerization	WAS	IDA		Human	PMID:29925947
Biological Process	GO:0030041	actin filament polymerization	Was	IDA		Mouse	PMID:12147689
Biological Process	GO:0030048	actin filament-based movement	Was	IDA		Mouse	PMID:12147689
Biological Process	GO:0008154	actin polymerization or depolymerization	Was	IDA		Mouse	PMID:12147689
Biological Process	GO:0032488	Cdc42 protein signal transduction	WAS	IMP		Human	PMID:8625410
Biological Process	GO:0071346	cellular response to type II interferon	Was	IDA		Mouse	PMID:19144319
Biological Process	GO:0016197	endosomal transport	Was	IDA		Mouse	PMID:12147689
Biological Process	GO:0006955	immune response	WAS	IMP		Human	PMID:8069912
Biological Process	GO:0030595	leukocyte chemotaxis	wasb	IMP	ZFIN:ZDB-GENO-090311-5	Zfish	PMID:18782862
Biological Process	GO:0030595	leukocyte chemotaxis	wasb	IMP	ZFIN:ZDB-MRPHLNO-090310-1	Zfish	PMID:18782862
Biological Process	GO:0048246	macrophage chemotaxis	wasb	IMP	ZFIN:ZDB-GENO-090311-5	Zfish	PMID:23868979
Biological Process	GO:2000146	negative regulation of cell motility	WAS	IMP		Human	PMID:22804504
Biological Process	GO:0051497	negative regulation of stress fiber assembly	WAS	IMP		Human	PMID:8625410
Biological Process	GO:0030593	neutrophil chemotaxis	wasb	IMP	ZFIN:ZDB-GENO-090311-5	Zfish	PMID:23868979
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	WAS	IDA		Human	PMID:29925947
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	WAS	IDA		Human	PMID:20574068
Biological Process	GO:0008064	regulation of actin polymerization or depolymerization	WAS	IMP		Human	PMID:8625410
Biological Process	GO:0010591	regulation of lamellipodium assembly	WAS	IGI	UniProtKB:P60953	Human	PMID:8625410
Biological Process	GO:0010591	regulation of lamellipodium assembly	WAS	IGI	UniProtKB:P63000	Human	PMID:8625410
Biological Process	GO:1902622	regulation of neutrophil migration	wasb	IMP	ZFIN:ZDB-GENO-090311-5	Zfish	PMID:23868979
Biological Process	GO:0051492	regulation of stress fiber assembly	WAS	IGI	UniProtKB:P60953	Human	PMID:8625410
Biological Process	GO:0051492	regulation of stress fiber assembly	WAS	IGI	UniProtKB:P63000	Human	PMID:8625410
Biological Process	GO:0002625	regulation of T cell antigen processing and presentation	WAS	IMP		Human	PMID:22804504
Biological Process	GO:0042110	T cell activation	Was	IMP	MGI:MGI:1861707	Mouse	PMID:11070165

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern