Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WNK3
  • Mouse genes Wnk3
  • Rat genes Wnk3
  • Zfish genes si:dkey-151g10.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wnk3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019869	chloride channel inhibitor activity	WNK3	IDA		Human	PMID:17673510
Molecular Function	GO:0005515	protein binding	WNK3	IPI	UniProtKB:P42574	Human	PMID:16501604
Molecular Function	GO:0005515	protein binding	WNK3	IPI	UniProtKB:P52954	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	WNK3	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0004672	protein kinase activity	WNK3	IDA		Human	PMID:16275913
Molecular Function	GO:0004674	protein serine/threonine kinase activity	WNK3	IDA		Human	PMID:17975670
Cellular Component	GO:0005912	adherens junction	Wnk3	IDA		Mouse	MGI:MGI:5009409|PMID:16275913
Cellular Component	GO:0005923	bicellular tight junction	Wnk3	IDA		Mouse	MGI:MGI:5009409|PMID:16275913
Cellular Component	GO:0005737	cytoplasm	WNK3	IDA		Human	PMID:16501604
Biological Process	GO:0006884	cell volume homeostasis	WNK3	IMP		Human	PMID:27782176
Biological Process	GO:0006884	cell volume homeostasis	Wnk3	IMP		Mouse	MGI:MGI:6221361|PMID:27782176
Biological Process	GO:0035633	maintenance of blood-brain barrier	Wnk3	IMP		Mouse	MGI:MGI:6221361|PMID:27782176
Biological Process	GO:0050801	monoatomic ion homeostasis	WNK3	IMP		Human	PMID:21613606
Biological Process	GO:0043066	negative regulation of apoptotic process	WNK3	IMP		Human	PMID:16501604
Biological Process	GO:0090188	negative regulation of pancreatic juice secretion	Wnk3	IMP		Mouse	MGI:MGI:5002793|PMID:21317537
Biological Process	GO:0007231	osmosensory signaling pathway	WNK3	IMP		Human	PMID:27782176
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Wnk3	IMP		Mouse	MGI:MGI:6221361|PMID:27782176
Biological Process	GO:0051928	positive regulation of calcium ion transport	WNK3	IMP		Human	PMID:18768590
Biological Process	GO:0032414	positive regulation of ion transmembrane transporter activity	WNK3	IDA		Human	PMID:16275913
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	WNK3	IDA		Human	PMID:16275913
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	WNK3	IDA		Human	PMID:16275913
Biological Process	GO:2000651	positive regulation of sodium ion transmembrane transporter activity	WNK3	IDA		Human	PMID:16275913
Biological Process	GO:2000651	positive regulation of sodium ion transmembrane transporter activity	WNK3	IMP		Human	PMID:21613606
Biological Process	GO:0010765	positive regulation of sodium ion transport	WNK3	IDA		Human	PMID:16275913
Biological Process	GO:0046777	protein autophosphorylation	WNK3	IDA		Human	PMID:16275913
Biological Process	GO:0072659	protein localization to plasma membrane	WNK3	IMP		Human	PMID:18768590
Biological Process	GO:0090279	regulation of calcium ion import	WNK3	IMP		Human	PMID:18768590
Biological Process	GO:1904062	regulation of monoatomic cation transmembrane transport	WNK3	IMP		Human	PMID:27782176
Biological Process	GO:1904062	regulation of monoatomic cation transmembrane transport	Wnk3	IMP		Mouse	MGI:MGI:6221361|PMID:27782176

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern