Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WNK4
  • Mouse genes Wnk4
  • Rat genes Wnk4
  • Zfish genes wnk4a,wnk4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wnk4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019869	chloride channel inhibitor activity	WNK4	IDA		Human	PMID:17673510
Molecular Function	GO:0031404	chloride ion binding	Wnk4	IMP	MGI:MGI:6414871	Mouse	PMID:30765526
Molecular Function	GO:0008200	ion channel inhibitor activity	Wnk4	IDA		Mouse	MGI:MGI:3688375|PMID:14608358
Molecular Function	GO:0005515	protein binding	WNK4	IPI	UniProtKB:O95747	Human	PMID:17721439
Molecular Function	GO:0005515	protein binding	WNK4	IPI	UniProtKB:Q9UH77	Human	PMID:23453970
Molecular Function	GO:0005515	protein binding	WNK4	IPI	UniProtKB:Q9UH77	Human	PMID:23576762
Molecular Function	GO:0005515	protein binding	WNK4	IPI	UniProtKB:O95747	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Wnk4	IPI	UniProtKB:P69744	Mouse	MGI:MGI:5550300|PMID:24434184
Molecular Function	GO:0005515	protein binding	Wnk4	IPI	UniProtKB:O00141	Mouse	MGI:MGI:6093077|PMID:17360471
Molecular Function	GO:0005515	protein binding	Wnk4	IPI	UniProtKB:Q13507-3	Mouse	MGI:MGI:5916493|PMID:21670282
Molecular Function	GO:0005515	protein binding	Wnk4	IPI	UniProtKB:Q9JLV5	Mouse	PMID:25250572
Molecular Function	GO:0005515	protein binding	Wnk4	IPI	UniProtKB:E0CZ16	Mouse	PMID:24821705
Molecular Function	GO:0005515	protein binding	Wnk4	IPI	UniProtKB:E0CZ16	Mouse	PMID:25313067
Molecular Function	GO:0005515	protein binding	Wnk4	IPI	UniProtKB:E0CZ16	Mouse	PMID:23576762
Molecular Function	GO:0005515	protein binding	Wnk4	IPI	RGD:1310466	Rat	PMID:16083423|RGD:1624357
Molecular Function	GO:0005515	protein binding	Wnk4	IPI	RGD:621643	Rat	PMID:16083423|RGD:1624357
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Wnk4	IDA		Rat	PMID:16083423|RGD:1624357
Cellular Component	GO:0005923	bicellular tight junction	Wnk4	IDA		Mouse	MGI:MGI:3690170|PMID:11498583
Cellular Component	GO:0044297	cell body	Wnk4	IMP	MGI:MGI:5427702	Mouse	PMID:31736353
Cellular Component	GO:0005737	cytoplasm	Wnk4	IDA		Mouse	PMID:14769928
Cellular Component	GO:0005829	cytosol	Wnk4	IDA		Rat	PMID:25515571|RGD:11535087
Cellular Component	GO:0016020	membrane	Wnk4	IDA		Rat	PMID:25515571|RGD:11535087
Cellular Component	GO:0032991	protein-containing complex	Wnk4	IDA		Mouse	PMID:25113964
Biological Process	GO:0032147	activation of protein kinase activity	Wnk4	IDA		Mouse	PMID:28096417
Biological Process	GO:0035932	aldosterone secretion	Wnk4	IMP	MGI:MGI:5427702	Mouse	PMID:22550170
Biological Process	GO:0055074	calcium ion homeostasis	Wnk4	IMP		Mouse	PMID:31496133
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Wnk4	IMP		Mouse	PMID:31496133
Biological Process	GO:0006821	chloride transport	Wnk4	IDA		Mouse	PMID:14769928
Biological Process	GO:0072156	distal tubule morphogenesis	WNK4	IMP		Human	PMID:23453970
Biological Process	GO:0072156	distal tubule morphogenesis	WNK4	IMP		Human	PMID:23576762
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Wnk4	IMP	MGI:MGI:3771073	Mouse	PMID:22114204
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Wnk4	IMP		Mouse	PMID:22114204
Biological Process	GO:0010467	gene expression	Wnk4	IMP	MGI:MGI:3771073	Mouse	PMID:22114204
Biological Process	GO:0010467	gene expression	Wnk4	IMP		Mouse	PMID:22114204
Biological Process	GO:0010467	gene expression	Wnk4	IMP		Mouse	PMID:23576762
Biological Process	GO:0010467	gene expression	Wnk4	IMP	MGI:MGI:5427702	Mouse	PMID:22550170
Biological Process	GO:0010467	gene expression	Wnk4	IGI	MGI:MGI:5646378	Mouse	PMID:28743496
Biological Process	GO:0010467	gene expression	Wnk4	IMP	MGI:MGI:6214838	Mouse	PMID:28314693
Biological Process	GO:0010467	gene expression	Wnk4	IMP	MGI:MGI:6214838	Mouse	PMID:24655003
Biological Process	GO:0010467	gene expression	Wnk4	IMP		Mouse	PMID:31496133
Biological Process	GO:0010467	gene expression	Wnk4	IMP	MGI:MGI:5427702	Mouse	PMID:24206662
Biological Process	GO:0010467	gene expression	Wnk4	IMP	MGI:MGI:5525135	Mouse	PMID:28365586
Biological Process	GO:0006954	inflammatory response	Wnk4	IMP	MGI:MGI:3771073	Mouse	PMID:31786261
Biological Process	GO:0030644	intracellular chloride ion homeostasis	Wnk4	IMP	MGI:MGI:6414871	Mouse	PMID:30765526
Biological Process	GO:0042116	macrophage activation	Wnk4	IMP	MGI:MGI:3771073	Mouse	PMID:31786261
Biological Process	GO:0050801	monoatomic ion homeostasis	WNK4	IMP		Human	PMID:23453970
Biological Process	GO:0050801	monoatomic ion homeostasis	WNK4	IMP		Human	PMID:23576762
Biological Process	GO:0050801	monoatomic ion homeostasis	Wnk4	IMP		Mouse	PMID:23576762
Biological Process	GO:0090188	negative regulation of pancreatic juice secretion	Wnk4	IMP		Mouse	PMID:21317537
Biological Process	GO:0006469	negative regulation of protein kinase activity	Wnk4	IMP	MGI:MGI:6414871	Mouse	PMID:30765526
Biological Process	GO:0010766	negative regulation of sodium ion transport	Wnk4	IDA		Rat	PMID:16204408|RGD:11535105
Biological Process	GO:0071805	potassium ion transmembrane transport	Wnk4	IMP	MGI:MGI:5525135	Mouse	PMID:28365586
Biological Process	GO:0070528	protein kinase C signaling	Wnk4	IDA		Mouse	PMID:28096417
Biological Process	GO:0008104	protein localization	Wnk4	IDA		Mouse	PMID:12671053
Biological Process	GO:0008104	protein localization	Wnk4	IDA		Mouse	PMID:12515852
Biological Process	GO:0006468	protein phosphorylation	Wnk4	IMP	MGI:MGI:5427702	Mouse	PMID:31736353
Biological Process	GO:0006468	protein phosphorylation	Wnk4	IMP	MGI:MGI:3771073	Mouse	PMID:31786261
Biological Process	GO:0006468	protein phosphorylation	Wnk4	IGI	MGI:MGI:5646378	Mouse	PMID:28743496
Biological Process	GO:0006468	protein phosphorylation	Wnk4	IMP	MGI:MGI:6214838	Mouse	PMID:24655003
Biological Process	GO:0006468	protein phosphorylation	Wnk4	IMP		Mouse	PMID:22114204
Biological Process	GO:0006468	protein phosphorylation	Wnk4	IMP	MGI:MGI:5427702	Mouse	PMID:24761002
Biological Process	GO:0006468	protein phosphorylation	Wnk4	IDA		Rat	PMID:16083423|RGD:1624357
Biological Process	GO:0045859	regulation of protein kinase activity	Wnk4	IMP		Mouse	PMID:29921588
Biological Process	GO:0070294	renal sodium ion absorption	WNK4	IMP		Human	PMID:23453970
Biological Process	GO:0070294	renal sodium ion absorption	WNK4	IMP		Human	PMID:23576762
Biological Process	GO:0003096	renal sodium ion transport	Wnk4	IDA		Mouse	MGI:MGI:3688375|PMID:14608358
Biological Process	GO:0002021	response to dietary excess	Wnk4	IMP	MGI:MGI:5427702	Mouse	PMID:24761002
Biological Process	GO:0002021	response to dietary excess	Wnk4	IMP	MGI:MGI:5427702	Mouse	PMID:22550170
Biological Process	GO:0002021	response to dietary excess	Wnk4	IMP	MGI:MGI:6214838	Mouse	PMID:28314693
Biological Process	GO:0009410	response to xenobiotic stimulus	Wnk4	IGI	MGI:MGI:1917378	Mouse	PMID:24039833
Biological Process	GO:0007165	signal transduction	Wnk4	IMP	MGI:MGI:3771073	Mouse	PMID:21486947
Biological Process	GO:0035725	sodium ion transmembrane transport	Wnk4	IMP		Mouse	PMID:31736353
Biological Process	GO:0035725	sodium ion transmembrane transport	Wnk4	IMP	MGI:MGI:6214838	Mouse	PMID:24655003
Biological Process	GO:0035725	sodium ion transmembrane transport	Wnk4	IMP	MGI:MGI:5525135	Mouse	PMID:28365586
Biological Process	GO:0035725	sodium ion transmembrane transport	Wnk4	IMP	MGI:MGI:5427702	Mouse	PMID:25113964

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern