Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WNT1
  • Mouse genes Wnt1
  • Rat genes Wnt1
  • Zfish genes wnt1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wnt1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	Wnt1	IDA		Mouse	MGI:MGI:4456962|PMID:10557084
Molecular Function	GO:0005515	protein binding	Wnt1	IPI	UniProtKB:Q6DID7	Mouse	MGI:MGI:4397730|PMID:19841259
Molecular Function	GO:0005515	protein binding	Wnt1	IPI	UniProtKB:O75581	Mouse	MGI:MGI:5532920|PMID:11448771
Molecular Function	GO:0005515	protein binding	Wnt1	IPI	UniProtKB:O35082	Mouse	MGI:MGI:3718804|PMID:17690294
Molecular Function	GO:0005515	protein binding	Wnt1	IPI	UniProtKB:Q6DID7-1	Mouse	MGI:MGI:4397730|PMID:19841259
Molecular Function	GO:0005515	protein binding	Wnt1	IPI	UniProtKB:O75197	Mouse	MGI:MGI:4818258|PMID:11336703
Molecular Function	GO:0005515	protein binding	Wnt1	IPI	UniProtKB:O75581	Mouse	MGI:MGI:4839462|PMID:11029007
Molecular Function	GO:0005515	protein binding	Wnt1	IPI	PR:O88572	Mouse	PMID:16126904
Molecular Function	GO:0005515	protein binding	Wnt1	IPI	PR:Q9JJJ7	Mouse	PMID:10866835
Molecular Function	GO:0005515	protein binding	Wnt1	IPI	PR:Q91VN0	Mouse	PMID:11956231
Molecular Function	GO:0005515	protein binding	Wnt1	IPI	PR:Q01887	Mouse	PMID:15454084
Molecular Function	GO:0019904	protein domain specific binding	Wnt1	IPI	UniProtKB:Q01887	Mouse	MGI:MGI:3510085|PMID:15454084
Molecular Function	GO:0048018	receptor ligand activity	WNT1	IDA		Human	PMID:28733458
Molecular Function	GO:0048018	receptor ligand activity	Wnt1	IDA		Mouse	MGI:MGI:4456962|PMID:10557084
Cellular Component	GO:0009986	cell surface	Wnt1	IDA		Mouse	PMID:8710372
Cellular Component	GO:0005737	cytoplasm	WNT1	IDA		Human	PMID:11793365
Cellular Component	GO:0005737	cytoplasm	WNT1	IDA		Human	PMID:19756656
Cellular Component	GO:0005576	extracellular region	Wnt1	IDA		Mouse	MGI:MGI:4818258|PMID:11336703
Biological Process	GO:0031100	animal organ regeneration	Wnt1	IMP		Rat	PMID:20413689|RGD:2326223
Biological Process	GO:0036520	astrocyte-dopaminergic neuron signaling	Wnt1	IMP		Mouse	MGI:MGI:5770063|PMID:21752258
Biological Process	GO:0060348	bone development	WNT1	IMP		Human	PMID:23499309
Biological Process	GO:0035284	brain segmentation	wnt1	IMP	ZFIN:ZDB-MRPHLNO-050308-12	Zfish	PMID:15659486
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Wnt1	IGI	MGI:MGI:1197020	Mouse	PMID:16054034
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT1	IDA		Human	PMID:10644691
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT1	IMP		Human	PMID:12154096
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT1	IMP		Human	PMID:19756656
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT1	IMP		Human	PMID:19778454
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT1	IDA		Human	PMID:28733458
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	MGI:MGI:5693230|PMID:17239604
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IMP		Mouse	MGI:MGI:5770063|PMID:21752258
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	MGI:MGI:4835152|PMID:15265686
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	MGI:MGI:5009183|PMID:12121999
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	PMID:16207730
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	PMID:10937998
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IGI	MGI:MGI:1329040	Mouse	PMID:15143170
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	PMID:16543246
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	PMID:9652750
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	PMID:20383322
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	PMID:15282335
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	PMID:15064719
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt1	IDA		Mouse	PMID:11265645
Biological Process	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	Wnt1	IDA		Mouse	MGI:MGI:5705221|PMID:19951692
Biological Process	GO:0008283	cell population proliferation	Wnt1	IDA		Mouse	PMID:9160667
Biological Process	GO:0033278	cell proliferation in midbrain	Wnt1	IDA		Mouse	MGI:MGI:2679774|PMID:14557550
Biological Process	GO:0033278	cell proliferation in midbrain	Wnt1	IDA		Mouse	MGI:MGI:3045659|PMID:15121182
Biological Process	GO:0007267	cell-cell signaling	Wnt1	IDA		Mouse	MGI:MGI:4456962|PMID:10557084
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Wnt1	IEP		Rat	PMID:17400807|RGD:2326224
Biological Process	GO:0021551	central nervous system morphogenesis	Wnt1	IMP		Mouse	MGI:MGI:1931348|PMID:2202907
Biological Process	GO:0021549	cerebellum development	Wnt1	IMP		Mouse	MGI:MGI:82938|PMID:8848044
Biological Process	GO:0021588	cerebellum formation	Wnt1	IMP		Mouse	MGI:MGI:1931348|PMID:2202907
Biological Process	GO:0021587	cerebellum morphogenesis	wnt1	IMP	ZFIN:ZDB-GENO-081106-2	Zfish	PMID:18423594
Biological Process	GO:0021536	diencephalon development	Wnt1	IGI	MGI:MGI:102764	Mouse	PMID:18094027
Biological Process	GO:0071542	dopaminergic neuron differentiation	Wnt1	IMP		Mouse	MGI:MGI:5469218|PMID:23324743
Biological Process	GO:0000578	embryonic axis specification	Wnt1	IMP		Mouse	MGI:MGI:4822553|PMID:2534596
Biological Process	GO:1990403	embryonic brain development	Wnt1	IDA		Mouse	MGI:MGI:3045659|PMID:15121182
Biological Process	GO:0045444	fat cell differentiation	Wnt1	IDA		Mouse	PMID:15728361
Biological Process	GO:0021797	forebrain anterior/posterior pattern specification	Wnt1	IGI	MGI:MGI:102764	Mouse	PMID:18094027
Biological Process	GO:0021592	fourth ventricle development	wnt1	IMP	ZFIN:ZDB-MRPHLNO-050308-12	Zfish	PMID:18191121
Biological Process	GO:0071425	hematopoietic stem cell proliferation	Wnt1	IDA		Mouse	PMID:9160667
Biological Process	GO:0070365	hepatocyte differentiation	Wnt1	IMP		Rat	PMID:20413689|RGD:2326223
Biological Process	GO:0030902	hindbrain development	wnt1	IMP	ZFIN:ZDB-MRPHLNO-050308-12	Zfish	PMID:15659486
Biological Process	GO:0042472	inner ear morphogenesis	Wnt1	IGI	MGI:MGI:98956	Mouse	PMID:15961523
Biological Process	GO:0022037	metencephalon development	Wnt1	IMP	MGI:MGI:1857490	Mouse	PMID:2205396
Biological Process	GO:0030901	midbrain development	Wnt1	IDA		Mouse	MGI:MGI:2679774|PMID:14557550
Biological Process	GO:0030901	midbrain development	Wnt1	IMP		Mouse	MGI:MGI:82938|PMID:8848044
Biological Process	GO:0030901	midbrain development	Wnt1	IMP		Mouse	MGI:MGI:1931348|PMID:2202907
Biological Process	GO:0030901	midbrain development	Wnt1	IMP	MGI:MGI:1857490	Mouse	PMID:2205396
Biological Process	GO:1904948	midbrain dopaminergic neuron differentiation	Wnt1	IMP		Mouse	MGI:MGI:5469218|PMID:23324743
Biological Process	GO:0030917	midbrain-hindbrain boundary development	Wnt1	IMP	MGI:MGI:1857490	Mouse	PMID:2205396
Biological Process	GO:0030917	midbrain-hindbrain boundary development	wnt1	IGI	ZFIN:ZDB-MRPHLNO-060705-3,ZFIN:ZDB-MRPHLNO-060705-4	Zfish	PMID:12591239
Biological Process	GO:0022004	midbrain-hindbrain boundary maturation during brain development	Wnt1	IMP	MGI:MGI:1856382	Mouse	PMID:8555108
Biological Process	GO:0007520	myoblast fusion	Wnt1	IDA		Mouse	PMID:15282335
Biological Process	GO:0007520	myoblast fusion	Wnt1	IGI	MGI:MGI:96573	Mouse	PMID:15282335
Biological Process	GO:0014902	myotube differentiation	Wnt1	IGI	MGI:MGI:96573	Mouse	PMID:15282335
Biological Process	GO:0043066	negative regulation of apoptotic process	WNT1	IMP		Human	PMID:12154096
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	WNT1	IMP		Human	PMID:16194878
Biological Process	GO:0045596	negative regulation of cell differentiation	Wnt1	IMP		Mouse	MGI:MGI:5486577|PMID:9473323
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	WNT1	IMP		Human	PMID:17072303
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	WNT1	IDA		Human	PMID:16501043
Biological Process	GO:2000773	negative regulation of cellular senescence	WNT1	IDA		Human	PMID:16501043
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Wnt1	IMP		Mouse	MGI:MGI:3758508|PMID:10937998
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Wnt1	IDA		Mouse	PMID:10937998
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Wnt1	IDA		Mouse	PMID:15728361
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	Wnt1	IMP		Mouse	MGI:MGI:5770063|PMID:21752258
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Wnt1	IDA		Mouse	PMID:16601693
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	Wnt1	IDA		Mouse	PMID:16601693
Biological Process	GO:0022008	neurogenesis	Wnt1	IDA		Mouse	MGI:MGI:2679774|PMID:14557550
Biological Process	GO:0048663	neuron fate commitment	Wnt1	IMP	MGI:MGI:2153126	Mouse	PMID:16339193
Biological Process	GO:0048664	neuron fate determination	Wnt1	IMP	MGI:MGI:3046939	Mouse	PMID:16339193
Biological Process	GO:0008284	positive regulation of cell population proliferation	WNT1	IDA		Human	PMID:16501043
Biological Process	GO:0008284	positive regulation of cell population proliferation	WNT1	IMP		Human	PMID:19778454
Biological Process	GO:0061184	positive regulation of dermatome development	WNT1	IDA		Human	PMID:10654605
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Wnt1	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	WNT1	IDA		Human	PMID:10644691
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	WNT1	IMP		Human	PMID:19847889
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Wnt1	IDA		Mouse	MGI:MGI:4441133|PMID:12937339
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Wnt1	IDA		Mouse	PMID:9356179
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	WNT1	IMP		Human	PMID:19734317
Biological Process	GO:1902035	positive regulation of hematopoietic stem cell proliferation	Wnt1	IDA		Mouse	PMID:9160667
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	WNT1	IDA		Human	PMID:12154096
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	WNT1	IMP		Human	PMID:19756656
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	WNT1	IDA		Human	PMID:16501043
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Wnt1	IDA		Mouse	PMID:15143170
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wnt1	IDA		Mouse	MGI:MGI:5705221|PMID:19951692
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wnt1	IGI	MGI:MGI:1919385	Mouse	PMID:15574752
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wnt1	IDA		Mouse	PMID:15574752
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wnt1	IGI	MGI:MGI:1933114	Mouse	PMID:15574752
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wnt1	IDA		Mouse	PMID:9769173
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wnt1	IGI	MGI:MGI:1924828	Mouse	PMID:15574752
Biological Process	GO:0009611	response to wounding	WNT1	IEP		Human	PMID:17982423
Biological Process	GO:0042770	signal transduction in response to DNA damage	WNT1	IDA		Human	PMID:16501043
Biological Process	GO:0060061	Spemann organizer formation	Wnt1	IMP		Mouse	MGI:MGI:893982|PMID:9192640
Biological Process	GO:0021527	spinal cord association neuron differentiation	Wnt1	IGI	MGI:MGI:98956	Mouse	PMID:11877374
Biological Process	GO:0033077	T cell differentiation in thymus	Wnt1	IDA		Mouse	PMID:11265645
Biological Process	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	Wnt1	IDA		Mouse	PMID:16601693
Biological Process	GO:0016055	Wnt signaling pathway	Wnt1	IDA		Mouse	MGI:MGI:5700314|PMID:11357136

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern