Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WNT2
  • Mouse genes Wnt2
  • Rat genes Wnt2
  • Zfish genes wnt2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wnt2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	WNT2	IDA		Human	PMID:10557084
Molecular Function	GO:0005109	frizzled binding	WNT2	IPI	UniProtKB:Q9UP38	Human	PMID:10557084
Molecular Function	GO:0005109	frizzled binding	WNT2	IPI	UniProtKB:O00144	Human	PMID:19038973
Molecular Function	GO:0005109	frizzled binding	WNT2	IPI	UniProtKB:Q9NPG1	Human	PMID:19038973
Molecular Function	GO:0005515	protein binding	WNT2	IPI	UniProtKB:Q8N474	Human	PMID:10347172
Molecular Function	GO:0048018	receptor ligand activity	WNT2	IDA		Human	PMID:10557084
Molecular Function	GO:0048018	receptor ligand activity	WNT2	IMP		Human	PMID:17948129
Cellular Component	GO:0062023	collagen-containing extracellular matrix	WNT2	IDA		Human	PMID:15507471
Cellular Component	GO:0005737	cytoplasm	WNT2	IDA		Human	PMID:19038973
Cellular Component	GO:0005737	cytoplasm	WNT2	IDA		Human	PMID:19239325
Cellular Component	GO:0005737	cytoplasm	WNT2	IDA		Human	PMID:23610556
Cellular Component	GO:0005737	cytoplasm	Wnt2	IDA		Rat	PMID:17194898|RGD:2298807
Cellular Component	GO:0005576	extracellular region	WNT2	IDA		Human	PMID:19038973
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:20159597
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT2	IDA		Human	PMID:10347172
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT2	IDA		Human	PMID:10557084
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT2	IMP		Human	PMID:17948129
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT2	IDA		Human	PMID:20018874
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt2	IGI	MGI:MGI:1261834	Mouse	PMID:19686689
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt2	IDA		Mouse	PMID:9652750
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:20159597
Biological Process	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	WNT2	IDA		Human	PMID:20018874
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:20159597
Biological Process	GO:0060038	cardiac muscle cell proliferation	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:20159597
Biological Process	GO:0033278	cell proliferation in midbrain	WNT2	IDA		Human	PMID:20018874
Biological Process	GO:0033278	cell proliferation in midbrain	Wnt2	IMP		Mouse	MGI:MGI:4461115|PMID:20018874
Biological Process	GO:0007267	cell-cell signaling	WNT2	IDA		Human	PMID:10557084
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	WNT2	IEP		Human	PMID:15040835
Biological Process	GO:0050673	epithelial cell proliferation	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:19686689
Biological Process	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:19686689
Biological Process	GO:0072574	hepatocyte proliferation	wnt2	IMP	ZFIN:ZDB-MRPHLNO-110916-6	Zfish	PMID:21771809
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Wnt2	IMP	MGI:MGI:2177935	Mouse	PMID:8951051
Biological Process	GO:0001889	liver development	wnt2	IGI	ZFIN:ZDB-GENO-110916-2,ZFIN:ZDB-MRPHLNO-110916-6	Zfish	PMID:21771809
Biological Process	GO:0001889	liver development	wnt2	IGI	ZFIN:ZDB-GENO-100709-5,ZFIN:ZDB-MRPHLNO-110916-6	Zfish	PMID:21771809
Biological Process	GO:0001889	liver development	wnt2	IMP	ZFIN:ZDB-MRPHLNO-110916-6	Zfish	PMID:21771809
Biological Process	GO:0001889	liver development	wnt2	IGI	ZFIN:ZDB-MRPHLNO-060705-6,ZFIN:ZDB-MRPHLNO-110916-6	Zfish	PMID:21771809
Biological Process	GO:0030324	lung development	Wnt2	IEP		Rat	PMID:1377452|RGD:2314905
Biological Process	GO:0060492	lung induction	Wnt2	IGI	MGI:MGI:1261834	Mouse	PMID:19686689
Biological Process	GO:0061180	mammary gland epithelium development	WNT2	IEP		Human	PMID:8168088
Biological Process	GO:0010463	mesenchymal cell proliferation	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:19686689
Biological Process	GO:1904948	midbrain dopaminergic neuron differentiation	WNT2	IDA		Human	PMID:20018874
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:20159597
Biological Process	GO:0008284	positive regulation of cell population proliferation	WNT2	IDA		Human	PMID:10347172
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	WNT2	IDA		Human	PMID:10557084
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Wnt2	IMP		Rat	PMID:18302287|RGD:2298703
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:19686689
Biological Process	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:19686689
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	WNT2	IMP		Human	PMID:19734317
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Wnt2	IMP	MGI:MGI:4361155	Mouse	PMID:19686689
Biological Process	GO:0050769	positive regulation of neurogenesis	Wnt2	IDA		Mouse	MGI:MGI:4461115|PMID:20018874
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	WNT2	IDA		Human	PMID:20018874
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wnt2	IDA		Mouse	PMID:20159597
Biological Process	GO:0048794	swim bladder development	wnt2	IGI	ZFIN:ZDB-GENO-110916-2,ZFIN:ZDB-MRPHLNO-110916-6	Zfish	PMID:21771809
Biological Process	GO:0048794	swim bladder development	wnt2	IGI	ZFIN:ZDB-GENO-100709-5,ZFIN:ZDB-MRPHLNO-110916-6	Zfish	PMID:21771809
Biological Process	GO:0048794	swim bladder development	wnt2	IMP	ZFIN:ZDB-MRPHLNO-110916-6	Zfish	PMID:21771809
Biological Process	GO:0016055	Wnt signaling pathway	Wnt2	IGI	MGI:MGI:108571	Mouse	PMID:11092808

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern