Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WNT3
  • Mouse genes Wnt3
  • Rat genes Wnt3
  • Zfish genes wnt3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wnt3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	WNT3	IPI	UniProtKB:Q9UP38	Human	PMID:10557084
Molecular Function	GO:0005109	frizzled binding	WNT3	IPI	UniProtKB:O75084	Human	PMID:18313787
Molecular Function	GO:0005515	protein binding	WNT3	IPI	UniProtKB:O75084	Human	PMID:18313787
Molecular Function	GO:0005515	protein binding	WNT3	IPI	UniProtKB:O75084	Human	PMID:21314951
Molecular Function	GO:0005515	protein binding	WNT3	IPI	UniProtKB:P43652	Human	PMID:26902720
Molecular Function	GO:0005515	protein binding	WNT3	IPI	UniProtKB:Q61091	Human	PMID:31036956
Molecular Function	GO:0005515	protein binding	Wnt3	IPI	UniProtKB:O35082	Mouse	MGI:MGI:3718804|PMID:17690294
Molecular Function	GO:0005515	protein binding	Wnt3	IPI	UniProtKB:Q6DID7	Mouse	MGI:MGI:4397730|PMID:19841259
Molecular Function	GO:0005515	protein binding	Wnt3	IPI	UniProtKB:Q9CWT0	Mouse	PMID:10866835
Molecular Function	GO:0019904	protein domain specific binding	Wnt3	IPI	UniProtKB:Q01887	Mouse	MGI:MGI:3822212|PMID:19000841
Molecular Function	GO:0048018	receptor ligand activity	WNT3	IDA		Human	PMID:10557084
Molecular Function	GO:0048018	receptor ligand activity	WNT3	IDA		Human	PMID:28733458
Cellular Component	GO:0005737	cytoplasm	Wnt3	IDA		Rat	PMID:17194898|RGD:2298807
Cellular Component	GO:0031012	extracellular matrix	Wnt3	IDA		Mouse	PMID:8167409
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Wnt3	IMP	MGI:MGI:2178826	Mouse	PMID:10431240
Biological Process	GO:0009948	anterior/posterior axis specification	Wnt3	IMP	MGI:MGI:2450902	Mouse	PMID:18028899
Biological Process	GO:0009952	anterior/posterior pattern specification	Wnt3	IMP	MGI:MGI:2178826	Mouse	PMID:10431240
Biological Process	GO:0007411	axon guidance	Wnt3	IDA		Mouse	PMID:18716223
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT3	IDA		Human	PMID:10557084
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT3	IDA		Human	PMID:15588944
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT3	IDA		Human	PMID:18044981
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT3	IDA		Human	PMID:28733458
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt3	IGI	MGI:MGI:1329040	Mouse	PMID:18403408
Biological Process	GO:0044338	canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	WNT3	IMP		Human	PMID:20039315
Biological Process	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	WNT3	IMP		Human	PMID:25640183
Biological Process	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation	WNT3	IMP		Human	PMID:20039315
Biological Process	GO:1905474	canonical Wnt signaling pathway involved in stem cell proliferation	WNT3	IDA		Human	PMID:25640183
Biological Process	GO:0000902	cell morphogenesis	WNT3	IMP		Human	PMID:15588944
Biological Process	GO:0035844	cloaca development	wnt3	IMP	ZFIN:ZDB-MRPHLNO-120601-2	Zfish	PMID:26105184
Biological Process	GO:0009950	dorsal/ventral axis specification	Wnt3	IMP	MGI:MGI:2450903	Mouse	PMID:12569130
Biological Process	GO:0009950	dorsal/ventral axis specification	Wnt3	IMP	MGI:MGI:2450902	Mouse	PMID:12569130
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Wnt3	IMP	MGI:MGI:2450903	Mouse	PMID:12569130
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Wnt3	IMP	MGI:MGI:2450902	Mouse	PMID:12569130
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Wnt3	IMP	MGI:MGI:2450903	Mouse	PMID:12569130
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Wnt3	IMP	MGI:MGI:2450902	Mouse	PMID:12569130
Biological Process	GO:0007276	gamete generation	Wnt3	IGI	MGI:MGI:1914431	Mouse	PMID:23469192
Biological Process	GO:0010467	gene expression	Wnt3	IDA		Mouse	PMID:19690384
Biological Process	GO:0060323	head morphogenesis	Wnt3	IGI	MGI:MGI:1329040	Mouse	PMID:18403408
Biological Process	GO:0060174	limb bud formation	WNT3	IMP		Human	PMID:14872406
Biological Process	GO:0060173	limb development	Wnt3	IMP	MGI:MGI:2450902	Mouse	PMID:12569130
Biological Process	GO:0060173	limb development	Wnt3	IMP	MGI:MGI:2450903	Mouse	PMID:12569130
Biological Process	GO:0061180	mammary gland epithelium development	WNT3	IEP		Human	PMID:8168088
Biological Process	GO:0001707	mesoderm formation	Wnt3	IMP	MGI:MGI:2178826	Mouse	PMID:10431240
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	Wnt3	IDA		Mouse	PMID:18716223
Biological Process	GO:0048697	positive regulation of collateral sprouting in absence of injury	Wnt3	IDA		Mouse	PMID:18716223
Biological Process	GO:0010628	positive regulation of gene expression	WNT3	IDA		Human	PMID:25640183
Biological Process	GO:0010628	positive regulation of gene expression	Wnt3	IDA		Mouse	PMID:19690384
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	Wnt3	IDA		Mouse	MGI:MGI:5469218|PMID:23324743
Biological Process	GO:0050767	regulation of neurogenesis	WNT3	IMP		Human	PMID:25640183
Biological Process	GO:0060064	Spemann organizer formation at the anterior end of the primitive streak	Wnt3	IMP	MGI:MGI:2178826	Mouse	PMID:10431240
Biological Process	GO:0072089	stem cell proliferation	WNT3	IMP		Human	PMID:25640183
Biological Process	GO:0021794	thalamus development	wnt3	IGI	ZFIN:ZDB-MRPHLNO-050517-2,ZFIN:ZDB-MRPHLNO-120601-2	Zfish	PMID:22475147

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern