Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WNT4
  • Mouse genes Wnt4
  • Rat genes Wnt4
  • Zfish genes wnt4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wnt4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	Wnt4	IPI	UniProtKB:Q61089	Mouse	MGI:MGI:4835152|PMID:15265686
Molecular Function	GO:0005515	protein binding	Wnt4	IPI	UniProtKB:O35082	Mouse	MGI:MGI:3718804|PMID:17690294
Molecular Function	GO:0005515	protein binding	Wnt4	IPI	PR:P97299	Mouse	PMID:9853965
Molecular Function	GO:0005515	protein binding	Wnt4	IPI	UniProtKB:Q9CWT0	Mouse	PMID:10866835
Molecular Function	GO:0005515	protein binding	Wnt4	IPI	PR:Q91VN0	Mouse	PMID:11956231
Molecular Function	GO:0048018	receptor ligand activity	WNT4	IDA		Human	PMID:16959810
Molecular Function	GO:0003714	transcription corepressor activity	Wnt4	IDA		Mouse	MGI:MGI:2675528|PMID:12949260
Cellular Component	GO:0009986	cell surface	Wnt4	IDA		Mouse	MGI:MGI:66576|PMID:8167409
Cellular Component	GO:0005737	cytoplasm	WNT4	IDA		Human	PMID:16959810
Cellular Component	GO:0005737	cytoplasm	Wnt4	IDA		Rat	PMID:20126574|RGD:2326233
Cellular Component	GO:0031012	extracellular matrix	Wnt4	IDA		Mouse	PMID:8167409
Cellular Component	GO:0005615	extracellular space	WNT4	IDA		Human	PMID:16959810
Cellular Component	GO:0005615	extracellular space	Wnt4	IDA		Mouse	MGI:MGI:5487484|PMID:23027131
Cellular Component	GO:0005794	Golgi apparatus	Wnt4	IDA		Rat	PMID:12707392|RGD:727218
Biological Process	GO:0030325	adrenal gland development	WNT4	IEP		Human	PMID:12844346
Biological Process	GO:0048856	anatomical structure development	Wnt4	IGI	MGI:MGI:2446084	Mouse	PMID:16818445
Biological Process	GO:0097190	apoptotic signaling pathway	Wnt4	IGI	MGI:MGI:88276	Mouse	PMID:20454446
Biological Process	GO:0097190	apoptotic signaling pathway	Wnt4	IGI	MGI:MGI:96571	Mouse	PMID:20454446
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Wnt4	IMP		Mouse	PMID:16054034
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Wnt4	IGI	MGI:MGI:98960	Mouse	PMID:11948913
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT4	IDA		Human	PMID:15317892
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT4	IDA		Human	PMID:16959810
Biological Process	GO:0060070	canonical Wnt signaling pathway	WNT4	IDA		Human	PMID:18182450
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt4	IDA		Mouse	MGI:MGI:5571208|PMID:24681597
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt4	IDA		Mouse	MGI:MGI:4835152|PMID:15265686
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt4	IDA		Mouse	PMID:11265645
Biological Process	GO:0060070	canonical Wnt signaling pathway	Wnt4	IGI	MGI:MGI:88276	Mouse	PMID:20454446
Biological Process	GO:0030154	cell differentiation	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:15581876
Biological Process	GO:0045165	cell fate commitment	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:18351662
Biological Process	GO:0042074	cell migration involved in gastrulation	wnt4	IMP		Zfish	PMID:8541205|ZFIN:ZDB-PUB-961014-1143
Biological Process	GO:0042074	cell migration involved in gastrulation	wnt4	IMP	ZFIN:ZDB-MRPHLNO-050318-2	Zfish	PMID:15630025
Biological Process	GO:0042074	cell migration involved in gastrulation	wnt4	IMP	ZFIN:ZDB-MRPHLNO-050318-1	Zfish	PMID:15630025
Biological Process	GO:0071392	cellular response to estradiol stimulus	Wnt4	IEP		Rat	PMID:20126574|RGD:2326233
Biological Process	GO:0071464	cellular response to hydrostatic pressure	Wnt4	IEP		Rat	PMID:19118527|RGD:2326236
Biological Process	GO:0009267	cellular response to starvation	Wnt4	IEP		Mouse	PMID:23260145
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	WNT4	IEP		Human	PMID:15040835
Biological Process	GO:0001838	embryonic epithelial tube formation	Wnt4	IDA		Mouse	PMID:16546160
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	wnt4	IMP	ZFIN:ZDB-GENO-130429-5	Zfish	PMID:23375584
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	wnt4	IGI	ZFIN:ZDB-GENO-141212-7	Zfish	PMID:23375584
Biological Process	GO:0001837	epithelial to mesenchymal transition	WNT4	IEP		Human	PMID:12841867
Biological Process	GO:0008585	female gonad development	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:15162500
Biological Process	GO:0008585	female gonad development	Wnt4	IMP	MGI:MGI:4399122	Mouse	PMID:19830824
Biological Process	GO:0008585	female gonad development	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:20106871
Biological Process	GO:0030237	female sex determination	WNT4	IMP		Human	PMID:11283799
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Wnt4	IGI	MGI:MGI:104723	Mouse	PMID:16700629
Biological Process	GO:0007276	gamete generation	Wnt4	IGI	MGI:MGI:95586	Mouse	PMID:15162500
Biological Process	GO:0021986	habenula development	wnt4	IMP	ZFIN:ZDB-MRPHLNO-050318-1	Zfish	PMID:18060805
Biological Process	GO:0021986	habenula development	wnt4	IMP	ZFIN:ZDB-MRPHLNO-080515-3	Zfish	PMID:18060805
Biological Process	GO:0007507	heart development	wnt4	IGI	ZFIN:ZDB-MRPHLNO-050318-1,ZFIN:ZDB-MRPHLNO-050318-3,ZFIN:ZDB-MRPHLNO-050318-4	Zfish	PMID:15630025
Biological Process	GO:0042445	hormone metabolic process	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:12399432
Biological Process	GO:0033080	immature T cell proliferation in thymus	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:18617424
Biological Process	GO:0001822	kidney development	WNT4	IEP		Human	PMID:15312687
Biological Process	GO:0060993	kidney morphogenesis	Wnt4	IGI	MGI:MGI:98505	Mouse	PMID:23362348
Biological Process	GO:0001889	liver development	WNT4	IEP		Human	PMID:15312687
Biological Process	GO:0008584	male gonad development	WNT4	IMP		Human	PMID:11283799
Biological Process	GO:0008584	male gonad development	WNT4	IEP		Human	PMID:17848411
Biological Process	GO:0008584	male gonad development	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:15581876
Biological Process	GO:0061180	mammary gland epithelium development	WNT4	IEP		Human	PMID:8168088
Biological Process	GO:0140013	meiotic nuclear division	Wnt4	IGI	MGI:MGI:98958	Mouse	PMID:20106871
Biological Process	GO:0060231	mesenchymal to epithelial transition	Wnt4	IMP	MGI:MGI:1857435	Mouse	PMID:21295565
Biological Process	GO:0060231	mesenchymal to epithelial transition	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:7990960
Biological Process	GO:0072164	mesonephric tubule development	Wnt4	IGI	MGI:MGI:98505	Mouse	PMID:20040500
Biological Process	GO:0001823	mesonephros development	Wnt4	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0072210	metanephric nephron development	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:18346943
Biological Process	GO:0072273	metanephric nephron morphogenesis	Wnt4	IMP	MGI:MGI:4399122	Mouse	PMID:19830824
Biological Process	GO:0072174	metanephric tubule formation	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:21350016
Biological Process	GO:0001656	metanephros development	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:7990960
Biological Process	GO:2000180	negative regulation of androgen biosynthetic process	WNT4	IDA		Human	PMID:16959810
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Wnt4	IGI	MGI:MGI:88276	Mouse	PMID:20454446
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Wnt4	IGI	MGI:MGI:96571	Mouse	PMID:20454446
Biological Process	GO:0045596	negative regulation of cell differentiation	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:15581876
Biological Process	GO:0030336	negative regulation of cell migration	Wnt4	IGI	UniProtKB:P01112	Mouse	MGI:MGI:5487484|PMID:23027131
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	WNT4	IMP		Human	PMID:12949260
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Wnt4	IMP		Mouse	MGI:MGI:3839158|PMID:19301398
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Wnt4	IDA		Mouse	MGI:MGI:2675528|PMID:12949260
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	Wnt4	IGI	MGI:MGI:104723	Mouse	PMID:16700629
Biological Process	GO:0010629	negative regulation of gene expression	WNT4	IDA		Human	PMID:15317892
Biological Process	GO:0010629	negative regulation of gene expression	Wnt4	IMP		Mouse	PMID:11948913
Biological Process	GO:2000019	negative regulation of male gonad development	WNT4	IMP		Human	PMID:11283799
Biological Process	GO:0010894	negative regulation of steroid biosynthetic process	WNT4	IDA		Human	PMID:15317892
Biological Process	GO:0010894	negative regulation of steroid biosynthetic process	WNT4	IDA		Human	PMID:18182450
Biological Process	GO:0061369	negative regulation of testicular blood vessel morphogenesis	WNT4	IMP		Human	PMID:12949260
Biological Process	GO:2000225	negative regulation of testosterone biosynthetic process	WNT4	IMP		Human	PMID:12949260
Biological Process	GO:2000225	negative regulation of testosterone biosynthetic process	Wnt4	IMP		Mouse	MGI:MGI:2675528|PMID:12949260
Biological Process	GO:0061045	negative regulation of wound healing	Wnt4	IGI	UniProtKB:P01112	Mouse	MGI:MGI:5487484|PMID:23027131
Biological Process	GO:0072006	nephron development	Wnt4	IMP	MGI:MGI:1857435	Mouse	PMID:21295565
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	Wnt4	IDA		Mouse	PMID:18617424
Biological Process	GO:0038030	non-canonical Wnt signaling pathway via MAPK cascade	WNT4	IDA		Human	PMID:17720811
Biological Process	GO:0048599	oocyte development	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:9989404
Biological Process	GO:0048599	oocyte development	Wnt4	IGI	MGI:MGI:88276	Mouse	PMID:20454446
Biological Process	GO:0048599	oocyte development	Wnt4	IGI	MGI:MGI:96571	Mouse	PMID:20454446
Biological Process	GO:0061205	paramesonephric duct development	WNT4	IMP		Human	PMID:18182450
Biological Process	GO:0061205	paramesonephric duct development	Wnt4	IMP		Mouse	MGI:MGI:3777712|PMID:14695376
Biological Process	GO:0061205	paramesonephric duct development	Wnt4	IMP	MGI:MGI:4399122	Mouse	PMID:19830824
Biological Process	GO:1904238	pericyte cell differentiation	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:16546160
Biological Process	GO:1904238	pericyte cell differentiation	Wnt4	IDA		Mouse	PMID:16546160
Biological Process	GO:0032349	positive regulation of aldosterone biosynthetic process	WNT4	IDA		Human	PMID:16981135
Biological Process	GO:0030501	positive regulation of bone mineralization	WNT4	IDA		Human	PMID:17720811
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	WNT4	IDA		Human	PMID:17720811
Biological Process	GO:2000066	positive regulation of cortisol biosynthetic process	WNT4	IDA		Human	PMID:16981135
Biological Process	GO:0061184	positive regulation of dermatome development	WNT4	IDA		Human	PMID:10654605
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	WNT4	IDA		Human	PMID:16959810
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	WNT4	IDA		Human	PMID:16981135
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	WNT4	IDA		Human	PMID:18182450
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Wnt4	IDA		Mouse	MGI:MGI:4821086|PMID:11283799
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Wnt4	IMP		Mouse	MGI:MGI:3839158|PMID:19301398
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Wnt4	IDA		Mouse	PMID:9356179
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	wnt4	IPI	ZFIN:ZDB-GENE-040625-179	Zfish	PMID:20161747
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	wnt4	IPI	ZFIN:ZDB-GENE-040625-109	Zfish	PMID:20161747
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	Wnt4	IGI	UniProtKB:P01112	Mouse	MGI:MGI:5487484|PMID:23027131
Biological Process	GO:0043547	positive regulation of GTPase activity	Wnt4	IGI	UniProtKB:P01112	Mouse	MGI:MGI:5487484|PMID:23027131
Biological Process	GO:0045836	positive regulation of meiotic nuclear division	Wnt4	IGI	MGI:MGI:98958	Mouse	PMID:20106871
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	WNT4	IDA		Human	PMID:17720811
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Wnt4	IGI	UniProtKB:P01112	Mouse	MGI:MGI:5487484|PMID:23027131
Biological Process	GO:0048841	regulation of axon extension involved in axon guidance	wnt4	IGI	ZFIN:ZDB-MRPHLNO-080515-3,ZFIN:ZDB-MRPHLNO-131204-1	Zfish	PMID:23749482
Biological Process	GO:0048841	regulation of axon extension involved in axon guidance	wnt4	IMP	ZFIN:ZDB-MRPHLNO-080515-3	Zfish	PMID:23749482
Biological Process	GO:0048841	regulation of axon extension involved in axon guidance	wnt4	IGI	ZFIN:ZDB-MRPHLNO-080515-3,ZFIN:ZDB-MRPHLNO-131125-7	Zfish	PMID:23749482
Biological Process	GO:0022407	regulation of cell-cell adhesion	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:20106871
Biological Process	GO:0072033	renal vesicle formation	Wnt4	IMP		Mouse	PMID:16054034
Biological Process	GO:0072034	renal vesicle induction	Wnt4	IDA		Mouse	PMID:11507767
Biological Process	GO:0080021	response to benzoic acid	Wnt4	IEP		Rat	PMID:30476341|RGD:151893502
Biological Process	GO:0032355	response to estradiol	Wnt4	IEP		Rat	PMID:16551644|RGD:2289005
Biological Process	GO:0032526	response to retinoic acid	Wnt4	HEP		Rat	PMID:30329139|RGD:151893506
Biological Process	GO:0032526	response to retinoic acid	Wnt4	IEP		Rat	PMID:30476341|RGD:151893502
Biological Process	GO:0070654	sensory epithelium regeneration	wnt4	IEP		Zfish	PMID:21911394
Biological Process	GO:0060008	Sertoli cell differentiation	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:15581876
Biological Process	GO:0007548	sex differentiation	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:9989404
Biological Process	GO:0051145	smooth muscle cell differentiation	Wnt4	IDA		Mouse	PMID:16546160
Biological Process	GO:0051145	smooth muscle cell differentiation	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:16546160
Biological Process	GO:0060126	somatotropin secreting cell differentiation	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:18351662
Biological Process	GO:0033077	T cell differentiation in thymus	Wnt4	IDA		Mouse	PMID:11265645
Biological Process	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:10733525
Biological Process	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:18351662
Biological Process	GO:0035239	tube morphogenesis	Wnt4	IMP	MGI:MGI:1857453	Mouse	PMID:16546160

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern