Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WRAP53
  • Mouse genes Wrap53
  • Rat genes Wrap53
  • Zfish genes wrap53
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wrap53

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042393	histone binding	WRAP53	IPI	UniProtKB:P16104	Human	PMID:26734725
Molecular Function	GO:0042393	histone binding	WRAP53	IPI	UniProtKB:P16104	Human	PMID:27715493
Molecular Function	GO:0042802	identical protein binding	WRAP53	IPI	UniProtKB:Q9BUR4	Human	PMID:21072240
Molecular Function	GO:0005515	protein binding	WRAP53	IPI	UniProtKB:O14746	Human	PMID:19179534
Molecular Function	GO:0005515	protein binding	WRAP53	IPI	UniProtKB:O60832	Human	PMID:19179534
Molecular Function	GO:0005515	protein binding	WRAP53	IPI	UniProtKB:P38432	Human	PMID:21072240
Molecular Function	GO:0005515	protein binding	WRAP53	IPI	UniProtKB:Q16637	Human	PMID:21072240
Molecular Function	GO:0005515	protein binding	WRAP53	IPI	UniProtKB:O60832	Human	PMID:25467444
Molecular Function	GO:0005515	protein binding	WRAP53	IPI	UniProtKB:O77622	Human	PMID:25467444
Molecular Function	GO:0005515	protein binding	WRAP53	IPI	UniProtKB:P40227	Human	PMID:25467444
Molecular Function	GO:0005515	protein binding	WRAP53	IPI	UniProtKB:Q08AM6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	WRAP53	IPI	UniProtKB:Q5T6F2	Human	PMID:32296183
Molecular Function	GO:0044877	protein-containing complex binding	WRAP53	IDA		Human	PMID:25467444
Molecular Function	GO:0051087	protein-folding chaperone binding	WRAP53	IPI	UniProtKB:P17987	Human	PMID:25467444
Molecular Function	GO:0051087	protein-folding chaperone binding	WRAP53	IPI	UniProtKB:P48643	Human	PMID:25467444
Molecular Function	GO:0051087	protein-folding chaperone binding	WRAP53	IPI	UniProtKB:P49368	Human	PMID:25467444
Molecular Function	GO:0051087	protein-folding chaperone binding	WRAP53	IPI	UniProtKB:P50990	Human	PMID:25467444
Molecular Function	GO:0051087	protein-folding chaperone binding	WRAP53	IPI	UniProtKB:P50991	Human	PMID:25467444
Molecular Function	GO:0051087	protein-folding chaperone binding	WRAP53	IPI	UniProtKB:P78371	Human	PMID:25467444
Molecular Function	GO:0051087	protein-folding chaperone binding	WRAP53	IPI	UniProtKB:Q99832	Human	PMID:25467444
Molecular Function	GO:0003723	RNA binding	WRAP53	IDA		Human	PMID:19179534
Molecular Function	GO:0003723	RNA binding	WRAP53	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:20351177
Molecular Function	GO:0070034	telomerase RNA binding	WRAP53	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:20351177
Molecular Function	GO:0070034	telomerase RNA binding	WRAP53	IDA		Human	PMID:22547674
Molecular Function	GO:0070034	telomerase RNA binding	WRAP53	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:25467444
Molecular Function	GO:0070034	telomerase RNA binding	WRAP53	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:25467444
Molecular Function	GO:0070034	telomerase RNA binding	WRAP53	IDA		Human	PMID:26170453
Molecular Function	GO:0070034	telomerase RNA binding	WRAP53	IDA		Human	PMID:29695869
Molecular Function	GO:0070034	telomerase RNA binding	WRAP53	IDA		Human	PMID:29804836
Molecular Function	GO:0031625	ubiquitin protein ligase binding	WRAP53	IPI	UniProtKB:O76064	Human	PMID:25512560
Molecular Function	GO:0031625	ubiquitin protein ligase binding	WRAP53	IPI	UniProtKB:O76064	Human	PMID:27715493
Cellular Component	GO:0015030	Cajal body	WRAP53	IDA		Human	PMID:19179534
Cellular Component	GO:0015030	Cajal body	WRAP53	IDA		Human	PMID:19285445
Cellular Component	GO:0015030	Cajal body	WRAP53	IDA		Human	PMID:21072240
Cellular Component	GO:0015030	Cajal body	WRAP53	IDA		Human	PMID:22547674
Cellular Component	GO:0015030	Cajal body	WRAP53	IMP		Human	PMID:25467444
Cellular Component	GO:0015030	Cajal body	WRAP53	IDA		Human	PMID:26170453
Cellular Component	GO:0005829	cytosol	WRAP53	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	WRAP53	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	WRAP53	IDA		Human	GO_REF:0000052
Cellular Component	GO:0035861	site of double-strand break	WRAP53	IDA		Human	PMID:25512560
Cellular Component	GO:0035861	site of double-strand break	WRAP53	IDA		Human	PMID:26734725
Cellular Component	GO:0035861	site of double-strand break	WRAP53	IDA		Human	PMID:27715493
Cellular Component	GO:0005697	telomerase holoenzyme complex	WRAP53	IDA		Human	PMID:19179534
Cellular Component	GO:0005697	telomerase holoenzyme complex	WRAP53	IDA		Human	PMID:26170453
Cellular Component	GO:0005697	telomerase holoenzyme complex	WRAP53	IDA		Human	PMID:29695869
Cellular Component	GO:0005697	telomerase holoenzyme complex	WRAP53	IDA		Human	PMID:29804836
Biological Process	GO:0030576	Cajal body organization	WRAP53	IMP		Human	PMID:21072240
Biological Process	GO:0045739	positive regulation of DNA repair	WRAP53	IDA		Human	PMID:25512560
Biological Process	GO:2000781	positive regulation of double-strand break repair	WRAP53	IDA		Human	PMID:27715493
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	WRAP53	IDA		Human	PMID:25512560
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	WRAP53	IDA		Human	PMID:25512560
Biological Process	GO:1904851	positive regulation of establishment of protein localization to telomere	WRAP53	IMP		Human	PMID:25467444
Biological Process	GO:0051973	positive regulation of telomerase activity	WRAP53	IDA		Human	PMID:19179534
Biological Process	GO:0051973	positive regulation of telomerase activity	WRAP53	IDA		Human	PMID:23685356
Biological Process	GO:0051973	positive regulation of telomerase activity	WRAP53	IMP		Human	PMID:23685356
Biological Process	GO:0051973	positive regulation of telomerase activity	WRAP53	IMP		Human	PMID:25467444
Biological Process	GO:0051973	positive regulation of telomerase activity	WRAP53	IDA		Human	PMID:29804836
Biological Process	GO:0051973	positive regulation of telomerase activity	Wrap53	IDA		Mouse	MGI:MGI:6189679|PMID:29804836
Biological Process	GO:1904867	protein localization to Cajal body	WRAP53	IDA		Human	PMID:22547674
Biological Process	GO:0034337	RNA folding	WRAP53	IDA		Human	PMID:29804836
Biological Process	GO:0090666	scaRNA localization to Cajal body	WRAP53	IDA		Human	PMID:19285445
Biological Process	GO:0090666	scaRNA localization to Cajal body	WRAP53	IMP		Human	PMID:25467444
Biological Process	GO:0090671	telomerase RNA localization to Cajal body	WRAP53	HMP		Human	PMID:25467444
Biological Process	GO:0090671	telomerase RNA localization to Cajal body	WRAP53	IMP		Human	PMID:25467444
Biological Process	GO:0032203	telomere formation via telomerase	WRAP53	IMP		Human	PMID:19179534
Biological Process	GO:0007004	telomere maintenance via telomerase	WRAP53	IDA		Human	PMID:23685356
Biological Process	GO:0007004	telomere maintenance via telomerase	WRAP53	IMP		Human	PMID:23685356
Biological Process	GO:0007004	telomere maintenance via telomerase	WRAP53	IDA		Human	PMID:29695869
Biological Process	GO:0007004	telomere maintenance via telomerase	WRAP53	IDA		Human	PMID:29804836

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern