Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WRN
  • Mouse genes Wrn
  • Rat genes Wrn
  • Zfish genes wrn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wrn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043138	3'-5' DNA helicase activity	WRN	IDA		Human	PMID:17715146
Molecular Function	GO:0008408	3'-5' exonuclease activity	WRN	IDA		Human	PMID:10783163
Molecular Function	GO:0008408	3'-5' exonuclease activity	WRN	IDA		Human	PMID:10871373
Molecular Function	GO:0008408	3'-5' exonuclease activity	WRN	IDA		Human	PMID:12181313
Molecular Function	GO:0008408	3'-5' exonuclease activity	WRN	IDA		Human	PMID:16622405
Molecular Function	GO:0008408	3'-5' exonuclease activity	Wrn	IDA		Mouse	PMID:10871373
Molecular Function	GO:0070337	3'-flap-structured DNA binding	WRN	IDA		Human	PMID:26420422
Molecular Function	GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	WRN	IDA		Human	PMID:19734539
Molecular Function	GO:0016887	ATP hydrolysis activity	WRN	IDA		Human	PMID:10373438
Molecular Function	GO:0016887	ATP hydrolysis activity	WRN	IDA		Human	PMID:10871376
Molecular Function	GO:0000405	bubble DNA binding	WRN	IDA		Human	PMID:11433031
Molecular Function	GO:0000405	bubble DNA binding	WRN	IDA		Human	PMID:11735402
Molecular Function	GO:0003682	chromatin binding	Wrn	IDA		Rat	PMID:19737542|RGD:10042988
Molecular Function	GO:0003677	DNA binding	WRN	IDA		Human	PMID:9288107
Molecular Function	GO:0003678	DNA helicase activity	WRN	IMP		Human	PMID:10871376
Molecular Function	GO:0003678	DNA helicase activity	WRN	IDA		Human	PMID:12181313
Molecular Function	GO:0003678	DNA helicase activity	WRN	IDA		Human	PMID:12944467
Molecular Function	GO:0003678	DNA helicase activity	WRN	IDA		Human	PMID:15200954
Molecular Function	GO:0003678	DNA helicase activity	WRN	IDA		Human	PMID:19734539
Molecular Function	GO:0003678	DNA helicase activity	WRN	IDA		Human	PMID:26420422
Molecular Function	GO:0003678	DNA helicase activity	WRN	IDA		Human	PMID:9288107
Molecular Function	GO:0004527	exonuclease activity	WRN	IDA		Human	PMID:12944467
Molecular Function	GO:0004527	exonuclease activity	WRN	IMP		Human	PMID:15200954
Molecular Function	GO:0061749	forked DNA-dependent helicase activity	WRN	IDA		Human	PMID:11735402
Molecular Function	GO:0000400	four-way junction DNA binding	WRN	IDA		Human	PMID:11735402
Molecular Function	GO:0009378	four-way junction helicase activity	WRN	IDA		Human	PMID:11433031
Molecular Function	GO:0009378	four-way junction helicase activity	WRN	IDA		Human	PMID:11735402
Molecular Function	GO:0051880	G-quadruplex DNA binding	WRN	IDA		Human	PMID:11433031
Molecular Function	GO:0051880	G-quadruplex DNA binding	WRN	IDA		Human	PMID:11735402
Molecular Function	GO:0000287	magnesium ion binding	WRN	IDA		Human	PMID:16622405
Molecular Function	GO:0030145	manganese ion binding	WRN	IDA		Human	PMID:16622405
Molecular Function	GO:0032405	MutLalpha complex binding	WRN	IDA		Human	PMID:17715146
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P27694	Human	PMID:10373438
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P12956	Human	PMID:10783163
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P13010	Human	PMID:10783163
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P12956	Human	PMID:11328876
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P04637	Human	PMID:11427532
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P39748	Human	PMID:11598021
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P54132	Human	PMID:11919194
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:Q15554	Human	PMID:12181313
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P43351	Human	PMID:12750383
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P09874	Human	PMID:14596914
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P39748	Human	PMID:14657243
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P39748	Human	PMID:14688284
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P09874	Human	PMID:14734561
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P12956	Human	PMID:14734561
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P04637	Human	PMID:15735006
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P27694	Human	PMID:15735006
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P27694	Human	PMID:15965237
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:Q9NUX5	Human	PMID:16030011
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P16104	Human	PMID:17498979
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:Q96FI4	Human	PMID:17611195
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P40692	Human	PMID:17715146
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P43246	Human	PMID:17715146
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:Q8IYB8	Human	PMID:17961633
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:Q96EB6	Human	PMID:18203716
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:Q96EB6	Human	PMID:19343720
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P29590-4	Human	PMID:21639834
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P27694	Human	PMID:24126761
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P45973	Human	PMID:25931448
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P12956	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	WRN	IPI	UniProtKB:P12956	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Wrn	IPI	UniProtKB:Q91XU0	Mouse	MGI:MGI:2135724|PMID:11301316
Molecular Function	GO:0042803	protein homodimerization activity	WRN	IDA		Human	PMID:10783163
Molecular Function	GO:0044877	protein-containing complex binding	WRN	IDA		Human	PMID:10783163
Molecular Function	GO:0061821	telomeric D-loop binding	WRN	IDA		Human	PMID:19734539
Molecular Function	GO:0061821	telomeric D-loop binding	WRN	IDA		Human	PMID:26420422
Molecular Function	GO:0061849	telomeric G-quadruplex DNA binding	WRN	IDA		Human	PMID:19734539
Molecular Function	GO:0000403	Y-form DNA binding	WRN	IDA		Human	PMID:11735402
Molecular Function	GO:0000403	Y-form DNA binding	WRN	IDA		Human	PMID:17715146
Molecular Function	GO:0000403	Y-form DNA binding	WRN	IDA		Human	PMID:26420422
Cellular Component	GO:0005813	centrosome	WRN	IDA		Human	PMID:17498979
Cellular Component	GO:0000781	chromosome, telomeric region	WRN	IDA		Human	PMID:15200954
Cellular Component	GO:0000781	chromosome, telomeric region	WRN	IDA		Human	PMID:26420422
Cellular Component	GO:0000781	chromosome, telomeric region	Wrn	IMP		Mouse	MGI:MGI:5700122|PMID:26195664
Cellular Component	GO:0043005	neuron projection	Wrn	IDA		Rat	PMID:12020873|RGD:10042989
Cellular Component	GO:0016607	nuclear speck	WRN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	WRN	IDA		Human	PMID:11420665
Cellular Component	GO:0005730	nucleolus	WRN	IDA		Human	PMID:12181313
Cellular Component	GO:0005730	nucleolus	WRN	IDA		Human	PMID:12944467
Cellular Component	GO:0005730	nucleolus	WRN	IDA		Human	PMID:15200954
Cellular Component	GO:0005730	nucleolus	WRN	IDA		Human	PMID:17498979
Cellular Component	GO:0005730	nucleolus	WRN	IDA		Human	PMID:21639834
Cellular Component	GO:0005730	nucleolus	WRN	IDA		Human	PMID:25801465
Cellular Component	GO:0005730	nucleolus	WRN	IDA		Human	PMID:9618508
Cellular Component	GO:0005654	nucleoplasm	WRN	IDA		Human	PMID:11420665
Cellular Component	GO:0005654	nucleoplasm	WRN	IDA		Human	PMID:12944467
Cellular Component	GO:0005654	nucleoplasm	WRN	IDA		Human	PMID:17498979
Cellular Component	GO:0005654	nucleoplasm	WRN	IDA		Human	PMID:21639834
Cellular Component	GO:0005654	nucleoplasm	WRN	IDA		Human	PMID:25801465
Cellular Component	GO:0005654	nucleoplasm	Wrn	IDA		Mouse	PMID:11420665
Cellular Component	GO:0005634	nucleus	Wrn	IDA		Mouse	PMID:9789047
Cellular Component	GO:0005657	replication fork	Wrn	IMP		Mouse	MGI:MGI:5700122|PMID:26195664
Biological Process	GO:0006284	base-excision repair	WRN	IDA		Human	PMID:17611195
Biological Process	GO:0007420	brain development	Wrn	IEP		Rat	PMID:12020873|RGD:10042989
Biological Process	GO:0071480	cellular response to gamma radiation	WRN	IDA		Human	PMID:21639834
Biological Process	GO:0009267	cellular response to starvation	WRN	IDA		Human	PMID:11420665
Biological Process	GO:0090398	cellular senescence	WRN	IMP		Human	PMID:18212065
Biological Process	GO:0008340	determination of adult lifespan	Wrn	IGI	MGI:MGI:109558	Mouse	PMID:15235603
Biological Process	GO:0006974	DNA damage response	WRN	IDA		Human	PMID:18203716
Biological Process	GO:0032508	DNA duplex unwinding	WRN	IDA		Human	PMID:11735402
Biological Process	GO:0032508	DNA duplex unwinding	WRN	IDA		Human	PMID:26420422
Biological Process	GO:0006259	DNA metabolic process	WRN	IDA		Human	PMID:16622405
Biological Process	GO:0006259	DNA metabolic process	Wrn	IMP	MGI:MGI:2156622	Mouse	PMID:11756244
Biological Process	GO:0006259	DNA metabolic process	Wrn	IMP	MGI:MGI:2156622	Mouse	PMID:12707040
Biological Process	GO:0006260	DNA replication	WRN	IMP		Human	PMID:12882351
Biological Process	GO:0006260	DNA replication	Wrn	IGI	UniProtKB:O88700	Mouse	MGI:MGI:5700122|PMID:26195664
Biological Process	GO:0006260	DNA replication	Wrn	IMP		Mouse	MGI:MGI:5700122|PMID:26195664
Biological Process	GO:0006260	DNA replication	Wrn	IMP	MGI:MGI:2156622	Mouse	PMID:9789047
Biological Process	GO:0000731	DNA synthesis involved in DNA repair	WRN	IDA		Human	PMID:17563354
Biological Process	GO:0006302	double-strand break repair	WRN	IMP		Human	PMID:21639834
Biological Process	GO:0044806	G-quadruplex DNA unwinding	WRN	IDA		Human	PMID:11735402
Biological Process	GO:0044806	G-quadruplex DNA unwinding	Wrn	IGI	UniProtKB:O88700	Mouse	MGI:MGI:5700122|PMID:26195664
Biological Process	GO:0044806	G-quadruplex DNA unwinding	Wrn	IMP		Mouse	MGI:MGI:5700122|PMID:26195664
Biological Process	GO:0051345	positive regulation of hydrolase activity	WRN	IDA		Human	PMID:17611195
Biological Process	GO:0098530	positive regulation of strand invasion	WRN	IDA		Human	PMID:26420422
Biological Process	GO:1902570	protein localization to nucleolus	WRN	IDA		Human	PMID:11420665
Biological Process	GO:0040009	regulation of growth rate	Wrn	IMP	MGI:MGI:2156622	Mouse	PMID:12707040
Biological Process	GO:0031297	replication fork processing	WRN	IMP		Human	PMID:12882351
Biological Process	GO:0031297	replication fork processing	WRN	IDA		Human	PMID:17115688
Biological Process	GO:0090399	replicative senescence	Wrn	IMP	MGI:MGI:2386438	Mouse	PMID:10757812
Biological Process	GO:0006979	response to oxidative stress	WRN	IDA		Human	PMID:17611195
Biological Process	GO:0010225	response to UV-C	WRN	IDA		Human	PMID:17563354
Biological Process	GO:0000723	telomere maintenance	WRN	IMP		Human	PMID:18212065
Biological Process	GO:0000723	telomere maintenance	Wrn	IGI	MGI:MGI:109558	Mouse	PMID:15235603
Biological Process	GO:0000723	telomere maintenance	Wrn	IGI	MGI:MGI:109558	Mouse	PMID:15367665
Biological Process	GO:0000723	telomere maintenance	Wrn	IGI	MGI:MGI:1328362	Mouse	PMID:15367665
Biological Process	GO:0000723	telomere maintenance	Wrn	IMP	MGI:MGI:2156622	Mouse	PMID:12707040
Biological Process	GO:0061820	telomeric D-loop disassembly	WRN	IDA		Human	PMID:15200954
Biological Process	GO:0061820	telomeric D-loop disassembly	WRN	IDA		Human	PMID:19734539
Biological Process	GO:0061820	telomeric D-loop disassembly	WRN	IGI	UniProtKB:O94761	Human	PMID:22039056
Biological Process	GO:0061820	telomeric D-loop disassembly	WRN	IDA		Human	PMID:26420422

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern