Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WWC1
  • Mouse genes Wwc1
  • Rat genes Wwc1
  • Zfish genes wwc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wwc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019900	kinase binding	WWC1	IPI	UniProtKB:P41743	Human	PMID:24682284
Molecular Function	GO:0019900	kinase binding	WWC1	IPI	UniProtKB:Q9NRM7	Human	PMID:24682284
Molecular Function	GO:0060090	molecular adaptor activity	WWC1	IDA		Human	PMID:24682284
Molecular Function	GO:0005515	protein binding	WWC1	IPI	UniProtKB:P63167	Human	PMID:16684779
Molecular Function	GO:0005515	protein binding	WWC1	IPI	UniProtKB:O95219	Human	PMID:17994011
Molecular Function	GO:0005515	protein binding	WWC1	IPI	UniProtKB:Q05513	Human	PMID:18190796
Molecular Function	GO:0005515	protein binding	WWC1	IPI	UniProtKB:Q08345	Human	PMID:18190796
Molecular Function	GO:0005515	protein binding	WWC1	IPI	UniProtKB:Q8N3V7	Human	PMID:18596123
Molecular Function	GO:0005515	protein binding	WWC1	IPI	UniProtKB:Q8NI35	Human	PMID:18596123
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Wwc1	IPI	RGD:621791|RGD:3399RGD:620961	Rat	PMID:19885391|RGD:5131959
Molecular Function	GO:0003713	transcription coactivator activity	WWC1	IDA		Human	PMID:16684779
Cellular Component	GO:0005737	cytoplasm	WWC1	IDA		Human	PMID:16684779
Cellular Component	GO:0005737	cytoplasm	WWC1	IDA		Human	PMID:18190796
Cellular Component	GO:0005737	cytoplasm	Wwc1	IDA		Mouse	MGI:MGI:3778558|PMID:18190796
Cellular Component	GO:0005829	cytosol	WWC1	IDA		Human	PMID:24682284
Cellular Component	GO:0005634	nucleus	WWC1	IDA		Human	PMID:16684779
Cellular Component	GO:0005634	nucleus	WWC1	IDA		Human	PMID:18190796
Cellular Component	GO:0048471	perinuclear region of cytoplasm	WWC1	IDA		Human	PMID:18596123
Cellular Component	GO:0032991	protein-containing complex	Wwc1	IDA		Rat	PMID:19885391|RGD:5131959
Cellular Component	GO:0032587	ruffle membrane	WWC1	IDA		Human	PMID:18190796
Biological Process	GO:0016477	cell migration	WWC1	IDA		Human	PMID:18596123
Biological Process	GO:0016477	cell migration	Wwc1	IMP		Rat	PMID:19885391|RGD:5131959
Biological Process	GO:0035331	negative regulation of hippo signaling	WWC1	IDA		Human	PMID:24682284
Biological Process	GO:0046621	negative regulation of organ growth	WWC1	IMP		Human	PMID:24682284
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	WWC1	IDA		Human	PMID:24682284
Biological Process	GO:0071599	otic vesicle development	wwc1	IMP	ZFIN:ZDB-MRPHLNO-151116-12	Zfish	PMID:25533962
Biological Process	GO:0032475	otolith formation	wwc1	IMP	ZFIN:ZDB-MRPHLNO-151116-12	Zfish	PMID:25533962
Biological Process	GO:0043410	positive regulation of MAPK cascade	WWC1	IDA		Human	PMID:18190796
Biological Process	GO:0035330	regulation of hippo signaling	WWC1	IMP		Human	PMID:20159598

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern