Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WWOX
  • Mouse genes Wwox
  • Rat genes Wwox
  • Zfish genes wwox
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wwox

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	WWOX	IPI	UniProtKB:Q12891	Human	PMID:19366691
Molecular Function	GO:0019899	enzyme binding	Wwox	IPI	UniProtKB:O35632	Mouse	MGI:MGI:3851310|PMID:19366691
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:P81408	Human	PMID:15064722
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:Q8N114	Human	PMID:15064722
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:Q8N114-3	Human	PMID:15064722
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:Q96G27	Human	PMID:15064722
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:Q99732	Human	PMID:15064722
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:P04637	Human	PMID:15580310
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:Q61527	Human	PMID:16061658
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:O14640	Human	PMID:19465938
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:O14641	Human	PMID:19465938
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:Q92997	Human	PMID:19465938
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:Q60838	Human	PMID:25678599
Molecular Function	GO:0005515	protein binding	WWOX	IPI	UniProtKB:Q67FY2	Human	PMID:25678599
Molecular Function	GO:0005515	protein binding	Wwox	IPI	PR:P02340	Mouse	PMID:11058590
Molecular Function	GO:0005515	protein binding	Wwox	IPI	PR:Q08775	Mouse	PMID:18487609
Molecular Function	GO:0003713	transcription coactivator activity	Wwox	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Cellular Component	GO:0005737	cytoplasm	WWOX	IDA		Human	PMID:19465938
Cellular Component	GO:0005829	cytosol	WWOX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	WWOX	IDA		Human	PMID:19366691
Cellular Component	GO:0005794	Golgi apparatus	WWOX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	WWOX	IDA		Human	PMID:15064722
Cellular Component	GO:0005902	microvillus	WWOX	IDA		Human	PMID:19366691
Cellular Component	GO:0005739	mitochondrion	Wwox	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Wwox	IDA		Mouse	PMID:11058590
Cellular Component	GO:0005654	nucleoplasm	WWOX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	WWOX	IDA		Human	PMID:19366691
Cellular Component	GO:0005634	nucleus	Wwox	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Cellular Component	GO:0005634	nucleus	Wwox	IDA		Mouse	PMID:11058590
Cellular Component	GO:0005886	plasma membrane	WWOX	IDA		Human	PMID:19366691
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Wwox	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	WWOX	IDA		Human	PMID:19366691
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Wwox	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Wwox	IDA		Mouse	PMID:19366691
Biological Process	GO:0006874	intracellular calcium ion homeostasis	wwox	IMP	ZFIN:ZDB-MRPHLNO-150302-1	Zfish	PMID:25649963
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	Wwox	IGI	MGI:MGI:98834	Mouse	PMID:11058590
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	WWOX	IDA		Human	PMID:19465938
Biological Process	GO:0001649	osteoblast differentiation	Wwox	IMP	MGI:MGI:3704944	Mouse	PMID:18487609
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Wwox	IMP		Mouse	MGI:MGI:3851310|PMID:19366691
Biological Process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	Wwox	IDA		Mouse	PMID:19366691
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wwox	IDA		Mouse	MGI:MGI:3851310|PMID:19366691
Biological Process	GO:0048705	skeletal system morphogenesis	Wwox	IMP	MGI:MGI:3704944	Mouse	PMID:18487609

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern