Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Wwtr1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes WWTR1
- Mouse genes Wwtr1
- Rat genes Wwtr1
- Zfish genes wwtr1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wwtr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:P62258	Human	PMID:16099986
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q15561	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q99594	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:P62258	Human	PMID:18227151
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:P84022	Human	PMID:18568018
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q13485	Human	PMID:18568018
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q15796	Human	PMID:18568018
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q96RN5	Human	PMID:18568018
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:P43699	Human	PMID:19010321
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q06710	Human	PMID:19010321
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:P28347	Human	PMID:19324877
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q15561	Human	PMID:19324877
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q15562	Human	PMID:19324877
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q99594	Human	PMID:19324877
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:O14640	Human	PMID:20412773
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:O14641	Human	PMID:20412773
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:O95835	Human	PMID:20412773
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q92997	Human	PMID:20412773
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q8IX12	Human	PMID:20594350
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:P62258	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q15561	Human	PMID:20972459
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q969T9	Human	PMID:20972459
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q9JLB2	Human	PMID:21145499
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:O95835	Human	PMID:22078877
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q14160	Human	PMID:22078877
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:P35222	Human	PMID:22234184
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:P35222	Human	PMID:23245942
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q9BZD6	Human	PMID:23873930
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q15561	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q99594	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q14160	Human	PMID:30126976
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q15561	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q99594	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:P28347-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q14005-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q15561	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q15562-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q8WWV3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q96LT6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	WWTR1	IPI	UniProtKB:Q9NUJ3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	UniProtKB:P45481\|UniProtKB:P46938\|UniProtKB:Q92831\|UniProtKB:Q99593	Mouse	MGI:MGI:3700430\|PMID:16332960
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	UniProtKB:Q8IX12	Mouse	MGI:MGI:4887296\|PMID:20594350
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	UniProtKB:O35625	Mouse	MGI:MGI:5603220\|PMID:24976009
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	UniProtKB:P46938\|UniProtKB:Q8BYR2	Mouse	MGI:MGI:4939579\|PMID:21145499
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	UniProtKB:Q07157\|UniProtKB:Q95168	Mouse	MGI:MGI:5512947\|PMID:20850437
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	UniProtKB:P35222	Mouse	MGI:MGI:5468195\|PMID:23245942
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	PR:P50220	Mouse	PMID:14970209
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	UniProtKB:P62260	Mouse	PMID:11118213
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	PR:Q3ULA2	Mouse	PMID:17636028
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	PR:Q9CQV8	Mouse	PMID:16099986
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	PR:P37238	Mouse	PMID:16099986
Molecular Function	GO:0005515	protein binding	Wwtr1	IPI	PR:P24610	Mouse	PMID:16300735
Molecular Function	GO:0042803	protein homodimerization activity	Wwtr1	IDA		Mouse	MGI:MGI:3700430\|PMID:16332960
Molecular Function	GO:0003713	transcription coactivator activity	WWTR1	IDA		Human	PMID:19010321
Molecular Function	GO:0003713	transcription coactivator activity	Wwtr1	IDA		Mouse	MGI:MGI:3700430\|PMID:16332960
Molecular Function	GO:0003714	transcription corepressor activity	Wwtr1	IGI	MGI:MGI:97747	Mouse	PMID:16099986
Cellular Component	GO:0005737	cytoplasm	WWTR1	IDA		Human	PMID:20412773
Cellular Component	GO:0005737	cytoplasm	WWTR1	IDA		Human	PMID:25849865
Cellular Component	GO:0005737	cytoplasm	Wwtr1	IDA		Mouse	PMID:16099986
Cellular Component	GO:0005737	cytoplasm	Wwtr1	IDA		Mouse	PMID:11118213
Cellular Component	GO:0005829	cytosol	WWTR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	WWTR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	WWTR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	WWTR1	IDA		Human	PMID:18568018
Cellular Component	GO:0005634	nucleus	WWTR1	IDA		Human	PMID:21145499
Cellular Component	GO:0005634	nucleus	WWTR1	IDA		Human	PMID:25849865
Cellular Component	GO:0005634	nucleus	Wwtr1	IDA		Mouse	MGI:MGI:4939579\|PMID:21145499
Cellular Component	GO:0005634	nucleus	Wwtr1	IDA		Mouse	PMID:19010321
Cellular Component	GO:0005634	nucleus	Wwtr1	IDA		Mouse	PMID:11118213
Cellular Component	GO:0005634	nucleus	Wwtr1	IDA		Mouse	PMID:16300735
Cellular Component	GO:0005634	nucleus	Wwtr1	IDA		Rat	PMID:19010321\|RGD:8553511
Cellular Component	GO:0005667	transcription regulator complex	Wwtr1	IDA		Mouse	PMID:14970209
Biological Process	GO:0034672	anterior/posterior pattern specification involved in pronephros development	wwtr1	IMP	ZFIN:ZDB-MRPHLNO-051101-2	Zfish	PMID:26248207
Biological Process	GO:0030509	BMP signaling pathway	wwtr1	IMP	ZFIN:ZDB-GENO-190226-9	Zfish	PMID:29809141
Biological Process	GO:0030509	BMP signaling pathway	wwtr1	IGI	ZFIN:ZDB-GENE-030131-9710	Zfish	PMID:29809141
Biological Process	GO:0007155	cell adhesion	wwtr1	IMP	ZFIN:ZDB-GENO-181105-3	Zfish	PMID:29283341
Biological Process	GO:0007155	cell adhesion	wwtr1	IGI	ZFIN:ZDB-GENE-030131-9710	Zfish	PMID:29283341
Biological Process	GO:0046844	chorion micropyle formation	wwtr1	IMP	ZFIN:ZDB-GENO-191031-5	Zfish	PMID:30608921
Biological Process	GO:0046844	chorion micropyle formation	wwtr1	IMP	ZFIN:ZDB-GENO-190402-3	Zfish	PMID:30327325
Biological Process	GO:0060271	cilium assembly	Wwtr1	IMP	MGI:MGI:3702742	Mouse	PMID:17251353
Biological Process	GO:0060271	cilium assembly	wwtr1	IGI	ZFIN:ZDB-MRPHLNO-090609-10,ZFIN:ZDB-MRPHLNO-200323-5	Zfish	PMID:31513014
Biological Process	GO:0061371	determination of heart left/right asymmetry	wwtr1	IGI	ZFIN:ZDB-MRPHLNO-090609-10,ZFIN:ZDB-MRPHLNO-200323-5	Zfish	PMID:31513014
Biological Process	GO:0061371	determination of heart left/right asymmetry	wwtr1	IMP	ZFIN:ZDB-MRPHLNO-200323-4	Zfish	PMID:31513014
Biological Process	GO:0061371	determination of heart left/right asymmetry	wwtr1	IMP	ZFIN:ZDB-GENO-201216-11	Zfish	PMID:31513014
Biological Process	GO:0061371	determination of heart left/right asymmetry	wwtr1	IGI	ZFIN:ZDB-GENO-201216-12	Zfish	PMID:31513014
Biological Process	GO:0061371	determination of heart left/right asymmetry	wwtr1	IMP	ZFIN:ZDB-MRPHLNO-051101-2	Zfish	PMID:31513014
Biological Process	GO:0048566	embryonic digestive tract development	wwtr1	IMP	ZFIN:ZDB-GENO-190214-3	Zfish	PMID:29859190
Biological Process	GO:0072148	epithelial cell fate commitment	wwtr1	IMP	ZFIN:ZDB-MRPHLNO-051101-2	Zfish	PMID:26248207
Biological Process	GO:1905590	fibronectin fibril organization	wwtr1	IMP	ZFIN:ZDB-GENO-181105-3	Zfish	PMID:29283341
Biological Process	GO:1905590	fibronectin fibril organization	wwtr1	IGI	ZFIN:ZDB-GENE-030131-9710	Zfish	PMID:29283341
Biological Process	GO:0032835	glomerulus development	Wwtr1	IMP	MGI:MGI:3775483	Mouse	PMID:18172001
Biological Process	GO:0003015	heart process	Wwtr1	IMP		Mouse	MGI:MGI:5509071\|PMID:23918388
Biological Process	GO:0035329	hippo signaling	WWTR1	IDA		Human	PMID:18227151
Biological Process	GO:0035329	hippo signaling	WWTR1	IDA		Human	PMID:20412773
Biological Process	GO:0001822	kidney development	wwtr1	IMP	ZFIN:ZDB-MRPHLNO-051101-2	Zfish	PMID:17636028
Biological Process	GO:0060993	kidney morphogenesis	Wwtr1	IMP	MGI:MGI:3759999	Mouse	PMID:17636028
Biological Process	GO:0070121	Kupffer's vesicle development	wwtr1	IGI	ZFIN:ZDB-MRPHLNO-090609-10,ZFIN:ZDB-MRPHLNO-200323-5	Zfish	PMID:31513014
Biological Process	GO:0048762	mesenchymal cell differentiation	Wwtr1	IMP	MGI:MGI:3759999	Mouse	PMID:17636028
Biological Process	GO:0035264	multicellular organism growth	Wwtr1	IMP	MGI:MGI:3759999	Mouse	PMID:17636028
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	WWTR1	IMP		Human	PMID:20412773
Biological Process	GO:0045599	negative regulation of fat cell differentiation	WWTR1	IGI	UniProtKB:Q96AC1	Human	PMID:29496737
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Wwtr1	IGI	MGI:MGI:97747	Mouse	PMID:16099986
Biological Process	GO:0006469	negative regulation of protein kinase activity	WWTR1	IMP		Human	PMID:20412773
Biological Process	GO:0001933	negative regulation of protein phosphorylation	WWTR1	IMP		Human	PMID:20412773
Biological Process	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	wwtr1	IMP	ZFIN:ZDB-MRPHLNO-051101-2	Zfish	PMID:26248207
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Wwtr1	IGI	MGI:MGI:97747	Mouse	PMID:16099986
Biological Process	GO:0001649	osteoblast differentiation	Wwtr1	IMP		Mouse	PMID:16099986
Biological Process	GO:0001649	osteoblast differentiation	Wwtr1	IGI	MGI:MGI:88177	Mouse	PMID:16099986
Biological Process	GO:0008284	positive regulation of cell population proliferation	WWTR1	IDA		Human	PMID:18227151
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	WWTR1	IDA		Human	PMID:18227151
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	WWTR1	IGI	UniProtKB:Q96AC1	Human	PMID:29496737
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	Wwtr1	IMP		Mouse	MGI:MGI:4939579\|PMID:21145499
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wwtr1	IDA		Mouse	PMID:14970209
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wwtr1	IGI	MGI:MGI:99829	Mouse	PMID:16099986
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wwtr1	IGI	MGI:MGI:97487	Mouse	PMID:16300735
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Wwtr1	IGI	MGI:MGI:108067	Mouse	PMID:14970209
Biological Process	GO:0016567	protein ubiquitination	Wwtr1	IMP		Mouse	MGI:MGI:5619460\|PMID:21474562
Biological Process	GO:0016567	protein ubiquitination	Wwtr1	IDA		Mouse	PMID:17636028
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	Wwtr1	IGI	MGI:MGI:103262	Mouse	PMID:23974041
Biological Process	GO:0006355	regulation of DNA-templated transcription	Wwtr1	IDA		Mouse	PMID:14970209
Biological Process	GO:0010468	regulation of gene expression	wwtr1	IGI	ZFIN:ZDB-GENE-030131-9710	Zfish	PMID:29283341
Biological Process	GO:0010468	regulation of gene expression	wwtr1	IMP	ZFIN:ZDB-GENO-181105-3	Zfish	PMID:29283341
Biological Process	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	Wwtr1	IGI	MGI:MGI:103262	Mouse	PMID:23974041
Biological Process	GO:0060390	regulation of SMAD protein signal transduction	WWTR1	IDA		Human	PMID:18568018
Biological Process	GO:0003406	retinal pigment epithelium development	wwtr1	IGI	ZFIN:ZDB-GENO-160122-4	Zfish	PMID:26209646
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Wwtr1	IMP	MGI:MGI:3759999	Mouse	PMID:17636028
Biological Process	GO:0001501	skeletal system development	wwtr1	IMP	ZFIN:ZDB-MRPHLNO-051101-2	Zfish	PMID:16099986
Biological Process	GO:0017145	stem cell division	WWTR1	IDA		Human	PMID:18568018
Biological Process	GO:0001894	tissue homeostasis	Wwtr1	IMP		Mouse	MGI:MGI:5509071\|PMID:23918388
Biological Process	GO:0001944	vasculature development	wwtr1	IMP	ZFIN:ZDB-GENO-190307-24	Zfish	PMID:29976931
Biological Process	GO:0001944	vasculature development	wwtr1	IGI	ZFIN:ZDB-GENE-030131-9710	Zfish	PMID:29976931
Biological Process	GO:0001570	vasculogenesis	wwtr1	IMP	ZFIN:ZDB-GENO-190307-24	Zfish	PMID:29976931
Biological Process	GO:0001570	vasculogenesis	wwtr1	IGI	ZFIN:ZDB-GENE-030131-9710	Zfish	PMID:29976931
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	wwtr1	IMP	ZFIN:ZDB-GENO-180611-9	Zfish	PMID:29773645

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.