Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes XBP1
  • Mouse genes Xbp1
  • Rat genes Xbp1
  • Zfish genes xbp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xbp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	XBP1	IDA		Human	PMID:2196176
Molecular Function	GO:0003700	DNA-binding transcription factor activity	XBP1	IDA		Human	PMID:1903538
Molecular Function	GO:0003700	DNA-binding transcription factor activity	XBP1	IDA		Human	PMID:8657566
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Xbp1	IDA		Mouse	MGI:MGI:5616311|PMID:20408817
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Xbp1	IDA		Rat	PMID:15486293|RGD:2326004
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Xbp1	IDA		Mouse	PMID:23152784
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	xbp1	IDA		Zfish	PMID:17560942
Molecular Function	GO:0042826	histone deacetylase binding	Xbp1	IPI	UniProtKB:Q9UQL6	Mouse	MGI:MGI:5616311|PMID:20408817
Molecular Function	GO:0042826	histone deacetylase binding	Xbp1	IPI	UniProtKB:Q96EB6	Mouse	MGI:MGI:5607229|PMID:20955178
Molecular Function	GO:0042802	identical protein binding	XBP1	IPI	UniProtKB:P17861	Human	PMID:20102225
Molecular Function	GO:0042802	identical protein binding	XBP1	IPI	UniProtKB:P17861	Human	PMID:23661758
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	Xbp1	IPI	UniProtKB:O08908|UniProtKB:P26450	Mouse	MGI:MGI:4442277|PMID:20348926
Molecular Function	GO:0005515	protein binding	XBP1	IPI	UniProtKB:P18850	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	XBP1	IPI	UniProtKB:Q9NS37	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	XBP1	IPI	UniProtKB:P18850	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	XBP1	IPI	UniProtKB:Q99941	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	XBP1	IPI	UniProtKB:Q9NS37	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	XBP1	IPI	UniProtKB:Q16665	Human	PMID:24670641
Molecular Function	GO:0005515	protein binding	XBP1	IPI	UniProtKB:Q13404	Human	PMID:32296183
Molecular Function	GO:0046982	protein heterodimerization activity	XBP1	IDA		Human	PMID:1903538
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Xbp1	IDA		Mouse	MGI:MGI:5607242|PMID:17612490
Molecular Function	GO:0043565	sequence-specific DNA binding	Xbp1	IDA		Mouse	MGI:MGI:5607245|PMID:8657566
Molecular Function	GO:0043565	sequence-specific DNA binding	Xbp1	IDA		Rat	PMID:15486293|RGD:2326004
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	XBP1	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Xbp1	IDA		Mouse	MGI:MGI:3798313|PMID:18556558
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	Xbp1	IPI	UniProtKB:O75928|UniProtKB:O75928|UniProtKB:Q8C5D8|UniProtKB:Q8C5D8	Mouse	MGI:MGI:5616311|PMID:20408817
Cellular Component	GO:0005737	cytoplasm	Xbp1	IDA		Mouse	MGI:MGI:4946566|PMID:21317886
Cellular Component	GO:0005737	cytoplasm	Xbp1	IDA		Mouse	MGI:MGI:5607243|PMID:16332684
Cellular Component	GO:0005737	cytoplasm	Xbp1	IDA		Rat	PMID:16912310|RGD:32733622
Cellular Component	GO:0005783	endoplasmic reticulum	XBP1	IDA		Human	PMID:23529610
Cellular Component	GO:0005634	nucleus	XBP1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005634	nucleus	Xbp1	IDA		Mouse	MGI:MGI:5616311|PMID:20408817
Cellular Component	GO:0005634	nucleus	Xbp1	IDA		Mouse	MGI:MGI:4946566|PMID:21317886
Cellular Component	GO:0005634	nucleus	Xbp1	IDA		Mouse	MGI:MGI:3798313|PMID:18556558
Cellular Component	GO:0005634	nucleus	Xbp1	IDA		Mouse	MGI:MGI:5607229|PMID:20955178
Cellular Component	GO:0005634	nucleus	Xbp1	IDA		Mouse	MGI:MGI:4442277|PMID:20348926
Cellular Component	GO:0005634	nucleus	Xbp1	IDA		Mouse	MGI:MGI:5607243|PMID:16332684
Cellular Component	GO:0005634	nucleus	Xbp1	IDA		Rat	PMID:15486293|RGD:2326004
Cellular Component	GO:0005634	nucleus	Xbp1	IDA		Rat	PMID:16912310|RGD:32733622
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	XBP1	IPI		Human	PMID:23661758
Biological Process	GO:0060612	adipose tissue development	Xbp1	IMP		Mouse	MGI:MGI:5496939|PMID:23623498
Biological Process	GO:0001525	angiogenesis	Xbp1	IMP		Mouse	MGI:MGI:5575452|PMID:23529610
Biological Process	GO:0071230	cellular response to amino acid stimulus	Xbp1	IDA		Mouse	MGI:MGI:5573106|PMID:24753614
Biological Process	GO:0071236	cellular response to antibiotic	Xbp1	IEP		Rat	PMID:19332540|RGD:7242708
Biological Process	GO:0071332	cellular response to fructose stimulus	Xbp1	IDA		Mouse	MGI:MGI:3798313|PMID:18556558
Biological Process	GO:0042149	cellular response to glucose starvation	Xbp1	IDA		Mouse	MGI:MGI:5607242|PMID:17612490
Biological Process	GO:0071333	cellular response to glucose stimulus	Xbp1	IDA		Mouse	MGI:MGI:3798313|PMID:18556558
Biological Process	GO:0032869	cellular response to insulin stimulus	Xbp1	IDA		Mouse	MGI:MGI:4442277|PMID:20348926
Biological Process	GO:0071353	cellular response to interleukin-4	Xbp1	IDA		Mouse	MGI:MGI:5605956|PMID:12612580
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Xbp1	IEP		Mouse	PMID:20439489
Biological Process	GO:0071222	cellular response to lipopolysaccharide	XBP1	IDA		Human	PMID:11460154
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Xbp1	IDA		Mouse	MGI:MGI:5605956|PMID:12612580
Biological Process	GO:0031670	cellular response to nutrient	Xbp1	IDA		Mouse	MGI:MGI:4442277|PMID:20348926
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Xbp1	IDA		Mouse	MGI:MGI:5496939|PMID:23623498
Biological Process	GO:0042632	cholesterol homeostasis	Xbp1	IMP		Mouse	MGI:MGI:3798313|PMID:18556558
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Xbp1	IDA		Mouse	MGI:MGI:5573106|PMID:24753614
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Xbp1	IDA		Mouse	MGI:MGI:5607242|PMID:17612490
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Xbp1	IDA		Rat	PMID:15171721|RGD:1304536
Biological Process	GO:0001935	endothelial cell proliferation	Xbp1	IMP		Mouse	MGI:MGI:5575452|PMID:23529610
Biological Process	GO:0060691	epithelial cell maturation involved in salivary gland development	Xbp1	IMP	MGI:MGI:2386788	Mouse	PMID:16362047
Biological Process	GO:0031017	exocrine pancreas development	Xbp1	IMP	MGI:MGI:2386788	Mouse	PMID:16362047
Biological Process	GO:0055089	fatty acid homeostasis	Xbp1	IMP		Mouse	MGI:MGI:3798313|PMID:18556558
Biological Process	GO:0002071	glandular epithelial cell maturation	Xbp1	IMP	MGI:MGI:2386788	Mouse	PMID:16362047
Biological Process	GO:0035188	hatching	xbp1	IMP	ZFIN:ZDB-MRPHLNO-130117-1	Zfish	PMID:17306247
Biological Process	GO:0035188	hatching	xbp1	IMP	ZFIN:ZDB-MRPHLNO-080121-2	Zfish	PMID:17306247
Biological Process	GO:0048785	hatching gland development	xbp1	IMP	ZFIN:ZDB-MRPHLNO-080121-2	Zfish	PMID:17306247
Biological Process	GO:0035356	intracellular triglyceride homeostasis	Xbp1	IMP		Mouse	MGI:MGI:3798313|PMID:18556558
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Xbp1	IMP		Mouse	MGI:MGI:3840374|PMID:19328063
Biological Process	GO:0001889	liver development	Xbp1	IMP		Mouse	MGI:MGI:1352298|PMID:10652269
Biological Process	GO:0001889	liver development	xbp1	IMP	ZFIN:ZDB-MRPHLNO-080121-2	Zfish	PMID:12633865
Biological Process	GO:0043066	negative regulation of apoptotic process	Xbp1	IMP		Mouse	MGI:MGI:1352298|PMID:10652269
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	XBP1	IDA		Human	PMID:19135031
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Xbp1	IMP		Rat	PMID:20625543|RGD:10047191
Biological Process	GO:0010832	negative regulation of myotube differentiation	Xbp1	IDA		Mouse	MGI:MGI:5607242|PMID:17612490
Biological Process	GO:0048666	neuron development	Xbp1	IDA		Mouse	MGI:MGI:5573106|PMID:24753614
Biological Process	GO:0045766	positive regulation of angiogenesis	XBP1	IMP		Human	PMID:25656649
Biological Process	GO:0045579	positive regulation of B cell differentiation	XBP1	IDA		Human	PMID:11460154
Biological Process	GO:0030335	positive regulation of cell migration	XBP1	IDA		Human	PMID:25656649
Biological Process	GO:0008284	positive regulation of cell population proliferation	XBP1	IDA		Human	PMID:25656649
Biological Process	GO:0008284	positive regulation of cell population proliferation	XBP1	IGI	RNAcentral:URS00002C11C3_9606	Human	PMID:25656649
Biological Process	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	XBP1	IMP		Human	PMID:16645094
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Xbp1	IMP		Mouse	MGI:MGI:5496939|PMID:23623498
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Xbp1	IMP		Mouse	MGI:MGI:1352298|PMID:10652269
Biological Process	GO:0002639	positive regulation of immunoglobulin production	XBP1	IDA		Human	PMID:11460154
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Xbp1	IDA		Mouse	MGI:MGI:5605956|PMID:12612580
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Xbp1	IDA		Mouse	MGI:MGI:5605956|PMID:12612580
Biological Process	GO:1903489	positive regulation of lactation	Xbp1	IMP		Mouse	MGI:MGI:5496939|PMID:23623498
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	XBP1	IMP		Human	PMID:1903538
Biological Process	GO:1900100	positive regulation of plasma cell differentiation	XBP1	IDA		Human	PMID:11460154
Biological Process	GO:0045582	positive regulation of T cell differentiation	XBP1	IDA		Human	PMID:11460154
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	XBP1	IMP		Human	PMID:1903538
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	XBP1	IDA		Human	PMID:8657566
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Xbp1	IDA		Mouse	MGI:MGI:5616311|PMID:20408817
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Xbp1	IDA		Mouse	MGI:MGI:4442277|PMID:20348926
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Xbp1	IMP		Mouse	MGI:MGI:1352298|PMID:10652269
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Xbp1	IDA		Mouse	MGI:MGI:5607229|PMID:20955178
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Xbp1	IDA		Mouse	MGI:MGI:3798313|PMID:18556558
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Xbp1	IDA		Mouse	MGI:MGI:5573106|PMID:24753614
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Xbp1	IDA		Mouse	PMID:23152784
Biological Process	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	Xbp1	IMP		Mouse	MGI:MGI:5605954|PMID:14559994
Biological Process	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	Xbp1	IDA		Mouse	MGI:MGI:5607243|PMID:16332684
Biological Process	GO:0035470	positive regulation of vascular wound healing	XBP1	IDA		Human	PMID:25656649
Biological Process	GO:0031648	protein destabilization	Xbp1	IMP		Mouse	MGI:MGI:5573106|PMID:24753614
Biological Process	GO:0010506	regulation of autophagy	Xbp1	IMP		Mouse	MGI:MGI:5573106|PMID:24753614
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Xbp1	IDA		Mouse	MGI:MGI:5496939|PMID:23623498
Biological Process	GO:0051602	response to electrical stimulus	Xbp1	IDA		Rat	PMID:16889758|RGD:2326003
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Xbp1	IDA		Mouse	MGI:MGI:4442277|PMID:20348926
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Xbp1	IDA		Mouse	MGI:MGI:5605956|PMID:12612580
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Xbp1	IDA		Mouse	MGI:MGI:5607229|PMID:20955178
Biological Process	GO:1990418	response to insulin-like growth factor stimulus	Xbp1	IDA		Mouse	MGI:MGI:5607242|PMID:17612490
Biological Process	GO:0009410	response to xenobiotic stimulus	Xbp1	IDA		Rat	PMID:20237065|RGD:2325999
Biological Process	GO:0060096	serotonin secretion, neurotransmission	Xbp1	IDA		Rat	PMID:16889758|RGD:2326003
Biological Process	GO:0055092	sterol homeostasis	Xbp1	IMP		Mouse	MGI:MGI:3798313|PMID:18556558
Biological Process	GO:0006366	transcription by RNA polymerase II	Xbp1	IDA		Mouse	MGI:MGI:5607242|PMID:17612490
Biological Process	GO:0006366	transcription by RNA polymerase II	Xbp1	IDA		Rat	PMID:15486293|RGD:2326004
Biological Process	GO:0006366	transcription by RNA polymerase II	xbp1	IDA		Zfish	PMID:17560942
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Xbp1	IMP		Mouse	MGI:MGI:5573106|PMID:24753614

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern