Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes XCL1,XCL2
  • Mouse genes Xcl1
  • Rat genes Xcl1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xcl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008009	chemokine activity	XCL1	IDA		Human	PMID:7602097
Molecular Function	GO:0008009	chemokine activity	Xcl1	IDA		Mouse	MGI:MGI:77040|PMID:7973732
Molecular Function	GO:0008009	chemokine activity	Xcl1	IDA		Mouse	MGI:MGI:5009207|PMID:9973465
Molecular Function	GO:0042379	chemokine receptor binding	XCL1	IDA		Human	PMID:9632725
Molecular Function	GO:0042379	chemokine receptor binding	Xcl1	IDA		Mouse	MGI:MGI:5009209|PMID:9632725
Molecular Function	GO:0005515	protein binding	XCL1	IPI	UniProtKB:P02776	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	XCL1	IPI	UniProtKB:P10720	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	XCL1	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	XCL1	IPI	UniProtKB:P48061	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	XCL1	IPI	UniProtKB:Q99616	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	XCL1	IPI	UniProtKB:Q9Y258	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	XCL2	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	XCL2	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	XCL2	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	XCL2	IPI	UniProtKB:P48061	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	XCL2	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	XCL1	IDA		Human	PMID:11889129
Cellular Component	GO:0005615	extracellular space	Xcl1	IDA		Mouse	MGI:MGI:5009207|PMID:9973465
Biological Process	GO:0007267	cell-cell signaling	XCL1	IDA		Human	PMID:7602097
Biological Process	GO:0071353	cellular response to interleukin-4	Xcl1	IDA		Mouse	MGI:MGI:85739|PMID:9013979
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Xcl1	IDA		Mouse	MGI:MGI:85739|PMID:9013979
Biological Process	GO:0006935	chemotaxis	Xcl1	IDA		Mouse	PMID:10518929
Biological Process	GO:0051649	establishment of localization in cell	Xcl1	IDA		Mouse	PMID:10518929
Biological Process	GO:0035782	mature natural killer cell chemotaxis	XCL1	IDA		Human	PMID:9029087
Biological Process	GO:0035782	mature natural killer cell chemotaxis	Xcl1	IDA		Mouse	MGI:MGI:85636|PMID:9029087
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	XCL1	IDA		Human	PMID:10887101
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	XCL1	IDA		Human	PMID:10887101
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	XCL1	IDA		Human	PMID:10887101
Biological Process	GO:0032703	negative regulation of interleukin-2 production	XCL1	IDA		Human	PMID:10887101
Biological Process	GO:0002725	negative regulation of T cell cytokine production	XCL1	IDA		Human	PMID:10887101
Biological Process	GO:2000518	negative regulation of T-helper 1 cell activation	XCL1	IDA		Human	PMID:10887101
Biological Process	GO:0032689	negative regulation of type II interferon production	XCL1	IDA		Human	PMID:10887101
Biological Process	GO:2000538	positive regulation of B cell chemotaxis	Xcl1	IDA		Mouse	MGI:MGI:5009193|PMID:11181058
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Xcl1	IDA		Mouse	MGI:MGI:5009207|PMID:9973465
Biological Process	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation	XCL1	IDA		Human	PMID:10887101
Biological Process	GO:2000513	positive regulation of granzyme A production	XCL1	IDA		Human	PMID:18832695
Biological Process	GO:0071663	positive regulation of granzyme B production	XCL1	IDA		Human	PMID:18832695
Biological Process	GO:2000558	positive regulation of immunoglobulin production in mucosal tissue	Xcl1	IDA		Mouse	MGI:MGI:5009207|PMID:9973465
Biological Process	GO:0032733	positive regulation of interleukin-10 production	XCL1	IDA		Human	PMID:18832695
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	Xcl1	IDA		Mouse	MGI:MGI:77040|PMID:7973732
Biological Process	GO:2000503	positive regulation of natural killer cell chemotaxis	XCL1	IDA		Human	PMID:9029087
Biological Process	GO:2000503	positive regulation of natural killer cell chemotaxis	Xcl1	IDA		Mouse	MGI:MGI:85636|PMID:9029087
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	Xcl1	IDA		Mouse	MGI:MGI:5009193|PMID:11181058
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	XCL1	IDA		Human	PMID:7602097
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	XCL1	IDA		Human	PMID:7602097
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	Xcl1	IDA		Mouse	MGI:MGI:85636|PMID:9029087
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	Xcl1	IDA		Mouse	MGI:MGI:5009212|PMID:8757601
Biological Process	GO:0002726	positive regulation of T cell cytokine production	Xcl1	IDA		Mouse	MGI:MGI:85636|PMID:9029087
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	XCL1	IDA		Human	PMID:18832695
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production	Xcl1	IDA		Mouse	MGI:MGI:5009207|PMID:9973465
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production	Xcl1	IDA		Mouse	MGI:MGI:5009207|PMID:9973465
Biological Process	GO:2000412	positive regulation of thymocyte migration	Xcl1	IDA		Mouse	MGI:MGI:77040|PMID:7973732
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	XCL1	IDA		Human	PMID:18832695
Biological Process	GO:0050727	regulation of inflammatory response	XCL1	IDA		Human	PMID:18832695
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Xcl1	IDA		Mouse	MGI:MGI:77040|PMID:7973732
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Xcl1	IDA		Mouse	PMID:10518929
Biological Process	GO:0009615	response to virus	XCL1	IDA		Human	PMID:14734774

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern