Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes XPC
  • Mouse genes Xpc
  • Rat genes Xpc
  • Zfish genes xpc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xpc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003684	damaged DNA binding	XPC	IDA		Human	PMID:12509299
Molecular Function	GO:0003684	damaged DNA binding	Xpc	IDA		Mouse	PMID:22431748
Molecular Function	GO:0140612	DNA damage sensor activity	XPC	IDA		Human	PMID:10873465
Molecular Function	GO:0140612	DNA damage sensor activity	XPC	IDA		Human	PMID:19941824
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P54727	Human	PMID:10488153
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P19447	Human	PMID:10734143
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P32780	Human	PMID:10734143
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P62195	Human	PMID:17693435
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P13288	Human	PMID:18024891
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P41208	Human	PMID:21962512
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P54727	Human	PMID:21962512
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P41208	Human	PMID:26638075
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P41208	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P54727	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:Q92830	Human	PMID:29973595
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P0C0S5	Human	PMID:31527837
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:Q92830	Human	PMID:31527837
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P41208	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	XPC	IPI	UniProtKB:P54727	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	Xpc	IPI	UniProtKB:P54728	Mouse	PMID:22431748
Molecular Function	GO:0044877	protein-containing complex binding	XPC	IDA		Human	PMID:11259578
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Xpc	IDA		Mouse	PMID:25901318
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Xpc	IPI	MGI:MGI:98364	Mouse	PMID:25901318
Molecular Function	GO:0003697	single-stranded DNA binding	XPC	IDA		Human	PMID:12509299
Molecular Function	GO:0003713	transcription coactivator activity	XPC	IDA		Human	PMID:29973595
Molecular Function	GO:0003713	transcription coactivator activity	XPC	IDA		Human	PMID:31527837
Cellular Component	GO:0005737	cytoplasm	XPC	IDA		Human	PMID:18682493
Cellular Component	GO:0005737	cytoplasm	Xpc	IDA		Rat	PMID:18979173|RGD:2317593
Cellular Component	GO:0005737	cytoplasm	Xpc	IDA		Rat	PMID:23022597|RGD:9590340
Cellular Component	GO:0005829	cytosol	XPC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	XPC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	XPC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	XPC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	XPC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000109	nucleotide-excision repair complex	XPC	IDA		Human	PMID:11259578
Cellular Component	GO:0005634	nucleus	XPC	IDA		Human	PMID:18682493
Cellular Component	GO:0005634	nucleus	Xpc	IDA		Mouse	PMID:12815074
Cellular Component	GO:0005634	nucleus	Xpc	IDA		Rat	PMID:18979173|RGD:2317593
Cellular Component	GO:0005634	nucleus	Xpc	IDA		Rat	PMID:23022597|RGD:9590340
Cellular Component	GO:0005886	plasma membrane	XPC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0090734	site of DNA damage	Xpc	IDA		Mouse	PMID:22431748
Cellular Component	GO:0071942	XPC complex	XPC	IDA		Human	PMID:11279143
Cellular Component	GO:0071942	XPC complex	XPC	IDA		Human	PMID:31527837
Biological Process	GO:0006974	DNA damage response	Xpc	IMP	MGI:MGI:1859840	Mouse	PMID:15010313
Biological Process	GO:0006281	DNA repair	Xpc	IMP	MGI:MGI:1859840	Mouse	PMID:12555660
Biological Process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	Xpc	IGI	MGI:MGI:101816	Mouse	PMID:15533840
Biological Process	GO:0006289	nucleotide-excision repair	XPC	IDA		Human	PMID:11259578
Biological Process	GO:0006289	nucleotide-excision repair	XPC	IDA		Human	PMID:19941824
Biological Process	GO:0006289	nucleotide-excision repair	XPC	IDA		Human	PMID:8168482
Biological Process	GO:0006289	nucleotide-excision repair	XPC	IDA		Human	PMID:9734359
Biological Process	GO:0006289	nucleotide-excision repair	Xpc	IDA		Mouse	PMID:22431748
Biological Process	GO:0006289	nucleotide-excision repair	Xpc	IMP	MGI:1931883	Mouse	PMID:17049932
Biological Process	GO:0006289	nucleotide-excision repair	Xpc	IMP	MGI:1931883	Mouse	PMID:19615386
Biological Process	GO:0006289	nucleotide-excision repair	Xpc	IDA		Mouse	PMID:12815074
Biological Process	GO:0006289	nucleotide-excision repair	Xpc	IMP	MGI:MGI:1859840	Mouse	PMID:9067411
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	XPC	IDA		Human	PMID:29973595
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	XPC	IDA		Human	PMID:31527837
Biological Process	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair	Xpc	IMP	MGI:1931883	Mouse	PMID:17049932
Biological Process	GO:1901990	regulation of mitotic cell cycle phase transition	XPC	IMP		Human	PMID:17088560
Biological Process	GO:0010996	response to auditory stimulus	Xpc	IEP		Rat	PMID:23022597|RGD:9590340
Biological Process	GO:0010224	response to UV-B	Xpc	IMP	MGI:MGI:1859840	Mouse	PMID:15010313
Biological Process	GO:0009410	response to xenobiotic stimulus	Xpc	IEP		Rat	PMID:19297277|RGD:2317581
Biological Process	GO:0070914	UV-damage excision repair	XPC	IDA		Human	PMID:8077226
Biological Process	GO:0070914	UV-damage excision repair	Xpc	IDA		Mouse	PMID:22431748

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern