Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes XPO1
  • Mouse genes Xpo1
  • Rat genes Xpo1
  • Zfish genes xpo1a,xpo1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xpo1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Xpo1	IPI	RGD:3889	Rat	PMID:27013579|RGD:151667433
Molecular Function	GO:0005049	nuclear export signal receptor activity	XPO1	IMP		Human	PMID:12724356
Molecular Function	GO:0005049	nuclear export signal receptor activity	XPO1	IMP		Human	PMID:12773398
Molecular Function	GO:0005049	nuclear export signal receptor activity	XPO1	IDA		Human	PMID:29666234
Molecular Function	GO:0005049	nuclear export signal receptor activity	Xpo1	IMP		Mouse	MGI:MGI:6390707|PMID:31340148
Molecular Function	GO:0005049	nuclear export signal receptor activity	Xpo1	IMP		Mouse	PMID:12446771
Molecular Function	GO:0005049	nuclear export signal receptor activity	Xpo1	IDA		Mouse	PMID:31340148
Molecular Function	GO:0005049	nuclear export signal receptor activity	Xpo1	IDA		Mouse	PMID:12446771
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O15504	Human	PMID:10358091
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P62826,UniProtKB:Q69383	Human	PMID:10557333
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q69383	Human	PMID:10557333
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q69383	Human	PMID:11000203
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q9H4D5	Human	PMID:11545741
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P62826,UniProtKB:Q96D46	Human	PMID:12724356
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O14980	Human	PMID:16302269
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P04626	Human	PMID:16314522
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P35232	Human	PMID:16319068
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O15392	Human	PMID:17099693
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P04637	Human	PMID:17268548
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P04637	Human	PMID:18952844
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O95149	Human	PMID:19339969
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P04618	Human	PMID:19339969
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O95149	Human	PMID:19339972
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P04618	Human	PMID:19339972
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q08211	Human	PMID:19955415
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P61925	Human	PMID:20485264
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O15392	Human	PMID:20826784
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q96EV8	Human	PMID:20921223
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q9Y3I1	Human	PMID:21378169
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O15131|UniProtKB:P07900|UniProtKB:P08238|UniProtKB:Q8TEX9	Human	PMID:22022502
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q2M3R5	Human	PMID:22084111
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O15504	Human	PMID:22250199
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P22736	Human	PMID:22427340
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q5TAQ9	Human	PMID:22500989
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q8NE35	Human	PMID:22730302
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O95149	Human	PMID:23850451
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q9WMX2	Human	PMID:24169621
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q99988	Human	PMID:25893289
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P63104	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:Q6ICB0	Human	PMID:29666234
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O00571	Human	PMID:30131165
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:O00571	Human	PMID:31575075
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P62826	Human	PMID:31575075
Molecular Function	GO:0005515	protein binding	XPO1	IPI	UniProtKB:P04626	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	UniProtKB:P62826	Mouse	MGI:MGI:5926574|PMID:23850451
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	UniProtKB:Q91WZ8	Mouse	MGI:MGI:5487529|PMID:20921223
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	UniProtKB:P0DJZ2	Mouse	MGI:MGI:5644029|PMID:10438867
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	UniProtKB:Q00987	Mouse	MGI:MGI:6092875|PMID:18952844
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	UniProtKB:O95149|UniProtKB:P61925|UniProtKB:P62826	Mouse	MGI:MGI:5926532|PMID:20972448
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	UniProtKB:B7ZR20|UniProtKB:O95149|UniProtKB:Q3B8L5|UniProtKB:Q6GNU1|UniProtKB:Q91855	Mouse	MGI:MGI:5770023|PMID:26673895
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	PR:Q61412	Mouse	PMID:15767664
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	UniProtKB:P0DJZ2	Rat	PMID:10438867|RGD:634528
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	UniProtKB:Q8VIP2	Rat	PMID:20025850|RGD:8554541
Molecular Function	GO:0005515	protein binding	Xpo1	IPI	UniProtKB:Q5M834	Rat	PMID:20921223|RGD:8553476
Molecular Function	GO:0019904	protein domain specific binding	Xpo1	IPI	UniProtKB:P0C205	Rat	PMID:11689633|RGD:634529
Cellular Component	GO:0005642	annulate lamellae	XPO1	IDA		Human	PMID:12210765
Cellular Component	GO:0005737	cytoplasm	XPO1	IDA		Human	PMID:23782956
Cellular Component	GO:0005737	cytoplasm	Xpo1	IDA		Rat	PMID:27013579|RGD:151667433
Cellular Component	GO:0005829	cytosol	XPO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	XPO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000776	kinetochore	XPO1	IDA		Human	PMID:17363900
Cellular Component	GO:0016020	membrane	XPO1	HDA		Human	PMID:19946888
Cellular Component	GO:0031965	nuclear membrane	XPO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	XPO1	IDA		Human	PMID:23782956
Cellular Component	GO:0005654	nucleoplasm	XPO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Xpo1	IDA		Mouse	PMID:16297385
Cellular Component	GO:0005634	nucleus	Xpo1	IDA		Rat	PMID:27013579|RGD:151667433
Cellular Component	GO:0032991	protein-containing complex	XPO1	IDA		Human	PMID:10557333
Cellular Component	GO:0032991	protein-containing complex	XPO1	IDA		Human	PMID:29666234
Cellular Component	GO:1990904	ribonucleoprotein complex	XPO1	IDA		Human	PMID:18809582
Biological Process	GO:0007420	brain development	xpo1a	IMP	ZFIN:ZDB-MRPHLNO-161206-1	Zfish	PMID:27699255
Biological Process	GO:1902075	cellular response to salt	Xpo1	IEP		Rat	PMID:27013579|RGD:151667433
Biological Process	GO:0071401	cellular response to triglyceride	Xpo1	IEP		Rat	PMID:27013579|RGD:151667433
Biological Process	GO:0006406	mRNA export from nucleus	Xpo1	IMP		Mouse	MGI:MGI:6390707|PMID:31340148
Biological Process	GO:0006406	mRNA export from nucleus	Xpo1	IDA		Mouse	PMID:31340148
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Xpo1	IMP		Rat	PMID:11689633|RGD:634529
Biological Process	GO:0006913	nucleocytoplasmic transport	XPO1	IMP		Human	PMID:11000203
Biological Process	GO:0006611	protein export from nucleus	XPO1	IMP		Human	PMID:22427340
Biological Process	GO:0006611	protein export from nucleus	XPO1	IMP		Human	PMID:12773398
Biological Process	GO:0006611	protein export from nucleus	XPO1	IDA		Human	PMID:22250199
Biological Process	GO:0006611	protein export from nucleus	XPO1	IDA		Human	PMID:29666234
Biological Process	GO:0006611	protein export from nucleus	XPO1	IPI	UniProtKB:Q6ICB0	Human	PMID:29666234
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IDA		Mouse	PMID:18606808
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IMP		Mouse	PMID:16316410
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IDA		Mouse	PMID:11796723
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IMP		Mouse	PMID:11092755
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IMP		Mouse	PMID:16236793
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IMP		Mouse	PMID:15767664
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IDA		Mouse	PMID:12446771
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IMP		Mouse	PMID:18496528
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IMP		Mouse	PMID:19952108
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IMP		Mouse	PMID:19064729
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IMP		Mouse	PMID:19699716
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IMP		Mouse	PMID:16459298
Biological Process	GO:0006611	protein export from nucleus	Xpo1	IDA		Rat	PMID:11689633|RGD:634529
Biological Process	GO:0008104	protein localization	Xpo1	IEP		Rat	PMID:27013579|RGD:151667433
Biological Process	GO:0034504	protein localization to nucleus	Xpo1	IMP		Mouse	PMID:16297385
Biological Process	GO:0010824	regulation of centrosome duplication	Xpo1	IMP		Mouse	PMID:16297385
Biological Process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	XPO1	IDA		Human	PMID:29666234
Biological Process	GO:0042176	regulation of protein catabolic process	Xpo1	IMP		Mouse	PMID:15767664
Biological Process	GO:0046825	regulation of protein export from nucleus	Xpo1	IMP		Mouse	PMID:14981260
Biological Process	GO:0009410	response to xenobiotic stimulus	Xpo1	IEP		Rat	PMID:11689633|RGD:634529
Biological Process	GO:0001878	response to yeast	xpo1b	IDA		Zfish	PMID:23947337
Biological Process	GO:0000055	ribosomal large subunit export from nucleus	XPO1	IMP		Human	PMID:12773398
Biological Process	GO:0000056	ribosomal small subunit export from nucleus	XPO1	IMP		Human	PMID:12773398
Biological Process	GO:0000054	ribosomal subunit export from nucleus	XPO1	IMP		Human	PMID:12724356
Biological Process	GO:0042254	ribosome biogenesis	XPO1	IMP		Human	PMID:12724356

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern