Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes XRCC3
  • Mouse genes Xrcc3
  • Rat genes Xrcc3
  • Zfish genes xrcc3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xrcc3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008821	crossover junction DNA endonuclease activity	XRCC3	IMP		Human	PMID:14716019
Molecular Function	GO:0008821	crossover junction DNA endonuclease activity	XRCC3	IMP		Human	PMID:23108668
Molecular Function	GO:0000400	four-way junction DNA binding	XRCC3	IDA		Human	PMID:20207730
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:O43502	Human	PMID:11751635
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:O43502	Human	PMID:11842113
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:Q06609	Human	PMID:11842113
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:Q6NVH7	Human	PMID:21965664
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:O43502	Human	PMID:24005329
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:O43502	Human	PMID:24141787
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:Q86YC2	Human	PMID:24141787
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:O43502	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:O43502	Human	PMID:28864920
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:Q06609	Human	PMID:28864920
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:O43502	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:O43502	Human	PMID:9469824
Molecular Function	GO:0005515	protein binding	XRCC3	IPI	UniProtKB:Q06609	Human	PMID:9660962
Cellular Component	GO:0005737	cytoplasm	XRCC3	IDA		Human	PMID:16215984
Cellular Component	GO:0005829	cytosol	XRCC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	XRCC3	IDA		Human	PMID:20413593
Cellular Component	GO:0005654	nucleoplasm	XRCC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	XRCC3	IDA		Human	PMID:16215984
Cellular Component	GO:0005634	nucleus	XRCC3	IDA		Human	PMID:26323318
Cellular Component	GO:0048471	perinuclear region of cytoplasm	XRCC3	IDA		Human	PMID:16215984
Cellular Component	GO:0033065	Rad51C-XRCC3 complex	XRCC3	IDA		Human	PMID:11751635
Cellular Component	GO:0005657	replication fork	XRCC3	IDA		Human	PMID:20207730
Biological Process	GO:0006281	DNA repair	XRCC3	IGI		Human	PMID:10422536
Biological Process	GO:0000724	double-strand break repair via homologous recombination	XRCC3	IMP		Human	PMID:23149936
Biological Process	GO:0036297	interstrand cross-link repair	XRCC3	IMP		Human	PMID:26323318
Biological Process	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	XRCC3	IMP		Human	PMID:23108668
Biological Process	GO:0010824	regulation of centrosome duplication	XRCC3	IMP		Human	PMID:23108668
Biological Process	GO:0071140	resolution of mitotic recombination intermediates	XRCC3	IMP		Human	PMID:23108668
Biological Process	GO:0010033	response to organic substance	Xrcc3	IEP		Rat	PMID:15256147|RGD:2302853
Biological Process	GO:0090656	t-circle formation	XRCC3	IMP		Human	PMID:21903669
Biological Process	GO:0000722	telomere maintenance via recombination	XRCC3	IMP		Human	PMID:15507207
Biological Process	GO:0090737	telomere maintenance via telomere trimming	XRCC3	IGI	UniProtKB:O60934	Human	PMID:27918544

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern