Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Xrcc5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes XRCC5
- Mouse genes Xrcc5
- Rat genes Xrcc5
- Zfish genes xrcc5
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xrcc5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051575	5'-deoxyribose-5-phosphate lyase activity	XRCC5	IMP		Human	PMID:20383123
Molecular Function	GO:0016887	ATP hydrolysis activity	XRCC5	IDA		Human	PMID:9368068
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	XRCC5	IDA		Human	PMID:9368068
Molecular Function	GO:0045027	DNA end binding	XRCC5	IDA		Human	PMID:9368068
Molecular Function	GO:0045027	DNA end binding	XRCC5	IDA		Human	PMID:19549901
Molecular Function	GO:0003690	double-stranded DNA binding	Xrcc5	IDA		Rat	PMID:14576192\|RGD:1300423
Molecular Function	GO:0003691	double-stranded telomeric DNA binding	XRCC5	IDA		Human	PMID:10409678
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q14191	Human	PMID:10783163
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P35548	Human	PMID:12145306
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q13950	Human	PMID:12145306
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q9BXJ9	Human	PMID:12145306
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:O14746	Human	PMID:12377759
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q08211	Human	PMID:14704337
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P78545	Human	PMID:15075319
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:17159921
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:17283121
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P09629	Human	PMID:17308091
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:17308091
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P78527	Human	PMID:17308091
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q8IW19	Human	PMID:17396150
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q96EV8-1	Human	PMID:19142223
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P78527	Human	PMID:19303849
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P78527	Human	PMID:20023628
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P78527	Human	PMID:20085707
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q8IW19	Human	PMID:20098424
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P78527	Human	PMID:20711232
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:21070772
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P38432	Human	PMID:21070772
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:21679440
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:22451927
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P13693	Human	PMID:22451927
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P09874,UniProtKB:P12956	Human	PMID:22504299
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P09874,UniProtKB:P12956,UniProtKB:P78527	Human	PMID:22504299
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q8IW19	Human	PMID:23178593
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q6NT76	Human	PMID:23685356
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q8IW19	Human	PMID:23689425
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q9H4A6	Human	PMID:24485452
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q9BWK5	Human	PMID:24610814
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P04792	Human	PMID:25277244
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:25574025
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q9BUH6	Human	PMID:25574025
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q9BUH6-1	Human	PMID:25574025
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q9C0C2	Human	PMID:25749521
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q92570	Human	PMID:25852083
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q03468	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q00613	Human	PMID:26359349
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P78527	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q8WVD3	Human	PMID:26502055
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q9H967	Human	PMID:27248496
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:O15355	Human	PMID:28330616
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q8IW19	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q9BWK5	Human	PMID:28959974
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q9BUH6	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P12956	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:Q9UGI0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRCC5	IPI	UniProtKB:P27695	Human	PMID:8621488
Molecular Function	GO:0005515	protein binding	Xrcc5	IPI	UniProtKB:Q8BJA3	Mouse	MGI:MGI:5500098\|PMID:23685356
Molecular Function	GO:0005515	protein binding	Xrcc5	IPI	UniProtKB:Q8BHZ5	Mouse	MGI:MGI:6202149\|PMID:30017584
Molecular Function	GO:0005515	protein binding	Xrcc5	IPI	RGD:2643	Rat	PMID:14576192\|RGD:1300423
Molecular Function	GO:0044877	protein-containing complex binding	XRCC5	IPI	ComplexPortal:CPX-17	Human	PMID:12377759
Molecular Function	GO:0003723	RNA binding	XRCC5	IDA		Human	PMID:14704337
Molecular Function	GO:0003723	RNA binding	XRCC5	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	XRCC5	HDA		Human	PMID:22681889
Molecular Function	GO:0042162	telomeric DNA binding	XRCC5	IDA		Human	PMID:10535943
Molecular Function	GO:0000976	transcription cis-regulatory region binding	XRCC5	IDA		Human	PMID:18809223
Molecular Function	GO:0034511	U3 snoRNA binding	XRCC5	IDA		Human	PMID:32103174
Molecular Function	GO:0031625	ubiquitin protein ligase binding	XRCC5	IPI	UniProtKB:O76064	Human	PMID:22266820
Cellular Component	GO:0000781	chromosome, telomeric region	XRCC5	IDA		Human	PMID:10535943
Cellular Component	GO:0000781	chromosome, telomeric region	XRCC5	HDA		Human	PMID:19135898
Cellular Component	GO:0005737	cytoplasm	Xrcc5	IDA		Mouse	PMID:12604618
Cellular Component	GO:0005737	cytoplasm	Xrcc5	IDA		Rat	PMID:11175667\|RGD:2317102
Cellular Component	GO:0070418	DNA-dependent protein kinase complex	XRCC5	IPI		Human	PMID:28840859
Cellular Component	GO:0043564	Ku70:Ku80 complex	XRCC5	IPI		Human	PMID:11493912
Cellular Component	GO:0043564	Ku70:Ku80 complex	XRCC5	IDA		Human	PMID:20383123
Cellular Component	GO:0043564	Ku70:Ku80 complex	XRCC5	IDA		Human	PMID:24095731
Cellular Component	GO:0043564	Ku70:Ku80 complex	XRCC5	IDA		Human	PMID:26359349
Cellular Component	GO:0016020	membrane	XRCC5	HDA		Human	PMID:19946888
Cellular Component	GO:0070419	nonhomologous end joining complex	XRCC5	IDA		Human	PMID:20383123
Cellular Component	GO:0070419	nonhomologous end joining complex	XRCC5	IDA		Human	PMID:25941166
Cellular Component	GO:0005730	nucleolus	XRCC5	IDA		Human	PMID:32103174
Cellular Component	GO:0005654	nucleoplasm	XRCC5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	XRCC5	IDA		Human	PMID:32103174
Cellular Component	GO:0005634	nucleus	Xrcc5	IDA		Mouse	PMID:12604618
Cellular Component	GO:0005634	nucleus	Xrcc5	IDA		Rat	PMID:14576192\|RGD:1300423
Cellular Component	GO:0005886	plasma membrane	XRCC5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	XRCC5	IDA		Human	PMID:22504299
Cellular Component	GO:0032991	protein-containing complex	Xrcc5	IDA		Rat	PMID:14576192\|RGD:1300423
Cellular Component	GO:0032993	protein-DNA complex	XRCC5	IDA		Human	PMID:22504299
Cellular Component	GO:1990904	ribonucleoprotein complex	XRCC5	IDA		Human	PMID:14704337
Cellular Component	GO:0090734	site of DNA damage	XRCC5	IMP		Human	PMID:27248496
Cellular Component	GO:0032040	small-subunit processome	XRCC5	IDA		Human	PMID:32103174
Biological Process	GO:0002218	activation of innate immune response	XRCC5	IDA		Human	PMID:28712728
Biological Process	GO:0007420	brain development	Xrcc5	IEP		Rat	PMID:9674610\|RGD:2317105
Biological Process	GO:0071475	cellular hyperosmotic salinity response	Xrcc5	IDA		Rat	PMID:11175667\|RGD:2317102
Biological Process	GO:0071398	cellular response to fatty acid	Xrcc5	IEP		Rat	PMID:19180667\|RGD:2316259
Biological Process	GO:0071480	cellular response to gamma radiation	XRCC5	IDA		Human	PMID:26359349
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Xrcc5	IEP		Mouse	PMID:20439489
Biological Process	GO:0071481	cellular response to X-ray	Xrcc5	IDA		Rat	PMID:11966321\|RGD:727219
Biological Process	GO:0006974	DNA damage response	XRCC5	IMP		Human	PMID:27248496
Biological Process	GO:0006302	double-strand break repair	XRCC5	IMP		Human	PMID:19581589
Biological Process	GO:0006302	double-strand break repair	Xrcc5	IMP	MGI:MGI:2179987	Mouse	PMID:12531011
Biological Process	GO:0006302	double-strand break repair	Xrcc5	IGI	MGI:MGI:1335098	Mouse	PMID:12531011
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC5	IMP		Human	PMID:20383123
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC5	IDA		Human	PMID:26359349
Biological Process	GO:0060218	hematopoietic stem cell differentiation	Xrcc5	IMP	MGI:MGI:2152542	Mouse	PMID:17554309
Biological Process	GO:0071425	hematopoietic stem cell proliferation	Xrcc5	IMP	MGI:MGI:2152542	Mouse	PMID:17554309
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	xrcc5	IGI	ZFIN:ZDB-MRPHLNO-050725-1,ZFIN:ZDB-MRPHLNO-070126-7	Zfish	PMID:15914672
Biological Process	GO:0000237	leptotene	Xrcc5	IMP	MGI:MGI:2152542	Mouse	PMID:17010969
Biological Process	GO:0043066	negative regulation of apoptotic process	xrcc5	IMP	ZFIN:ZDB-MRPHLNO-050725-1	Zfish	PMID:15914672
Biological Process	GO:0043066	negative regulation of apoptotic process	xrcc5	IMP	ZFIN:ZDB-MRPHLNO-050725-1	Zfish	PMID:17638406
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	XRCC5	IMP		Human	PMID:8621488
Biological Process	GO:1904430	negative regulation of t-circle formation	XRCC5	IMP		Human	PMID:19581589
Biological Process	GO:0022008	neurogenesis	Xrcc5	IMP	MGI:MGI:2179987	Mouse	PMID:10716994
Biological Process	GO:0050769	positive regulation of neurogenesis	Xrcc5	IMP	MGI:MGI:2179987	Mouse	PMID:10716994
Biological Process	GO:0045860	positive regulation of protein kinase activity	XRCC5	IDA		Human	PMID:22504299
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	XRCC5	IMP		Human	PMID:19188702
Biological Process	GO:0048660	regulation of smooth muscle cell proliferation	XRCC5	IMP		Human	PMID:25852083
Biological Process	GO:0010212	response to ionizing radiation	xrcc5	IMP	ZFIN:ZDB-MRPHLNO-050725-1	Zfish	PMID:15914672
Biological Process	GO:0010212	response to ionizing radiation	xrcc5	IMP	ZFIN:ZDB-MRPHLNO-050725-1	Zfish	PMID:17638406
Biological Process	GO:0010212	response to ionizing radiation	xrcc5	IMP	ZFIN:ZDB-MRPHLNO-050725-1	Zfish	PMID:23092554
Biological Process	GO:0009410	response to xenobiotic stimulus	Xrcc5	IEP		Rat	PMID:17264098\|RGD:2314327
Biological Process	GO:0034462	small-subunit processome assembly	XRCC5	IDA		Human	PMID:32103174

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.