Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Xrcc6

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes XRCC6
- Mouse genes Xrcc6
- Rat genes Xrcc6
- Zfish genes xrcc6
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xrcc6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051575	5'-deoxyribose-5-phosphate lyase activity	XRCC6	IMP		Human	PMID:20383123
Molecular Function	GO:0016887	ATP hydrolysis activity	XRCC6	IDA		Human	PMID:9368068
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	XRCC6	IDA		Human	PMID:9368068
Molecular Function	GO:0030332	cyclin binding	XRCC6	IPI	UniProtKB:P78396	Human	PMID:15159402
Molecular Function	GO:0045027	DNA end binding	XRCC6	IDA		Human	PMID:9368068
Molecular Function	GO:0003678	DNA helicase activity	XRCC6	IDA		Human	PMID:9368068
Molecular Function	GO:0003690	double-stranded DNA binding	Xrcc6	IDA		Mouse	PMID:20150414
Molecular Function	GO:0003690	double-stranded DNA binding	Xrcc6	IDA		Rat	PMID:14576192\|RGD:1300423
Molecular Function	GO:0003691	double-stranded telomeric DNA binding	XRCC6	IDA		Human	PMID:10409678
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q14191	Human	PMID:10783163
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q15554	Human	PMID:10984620
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q14191	Human	PMID:11328876
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P35548	Human	PMID:12145306
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q13950	Human	PMID:12145306
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9BXJ9	Human	PMID:12145306
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:O14746	Human	PMID:12377759
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q14191	Human	PMID:14734561
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P78545	Human	PMID:15075319
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q07812	Human	PMID:15205477
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q96EB6	Human	PMID:15205477
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P42858	Human	PMID:15383276
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9NYB0	Human	PMID:15383534
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P04637	Human	PMID:15782130
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q96P48	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q13426	Human	PMID:17124166
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:17159921
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q92597	Human	PMID:17220478
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:17283121
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9NQB0	Human	PMID:17283121
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:17308091
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P78527	Human	PMID:17308091
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q96EB6	Human	PMID:17334224
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P78527	Human	PMID:19303849
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P78527	Human	PMID:20711232
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:21070772
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P38432	Human	PMID:21070772
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q08752	Human	PMID:21146485
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P78527	Human	PMID:21575865
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:21679440
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:O75398	Human	PMID:22442688
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:22451927
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13693	Human	PMID:22451927
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P09874,UniProtKB:P13010	Human	PMID:22504299
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P09874,UniProtKB:P13010,UniProtKB:P78527	Human	PMID:22504299
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q6NT76	Human	PMID:23685356
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q8IW19	Human	PMID:23689425
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q6NS38	Human	PMID:23972994
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P54274	Human	PMID:24095731
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q13426	Human	PMID:24095731
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q15554	Human	PMID:24095731
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9H9Q4	Human	PMID:24095731
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9BWK5	Human	PMID:24610814
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P19712:PRO_0000038050	Human	PMID:24965446
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:25574025
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9BUH6	Human	PMID:25574025
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P09874	Human	PMID:25749521
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P78527	Human	PMID:25749521
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9C0C2	Human	PMID:25749521
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q92570	Human	PMID:25852083
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P78527	Human	PMID:26175416
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q00613	Human	PMID:26359349
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P78527	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q13426	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q14191	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9NYB0	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13693	Human	PMID:27607350
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:O15355	Human	PMID:28330616
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q14191	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9BWK5	Human	PMID:28959974
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9NQB0	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P13010	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	XRCC6	IPI	UniProtKB:P27695	Human	PMID:8621488
Molecular Function	GO:0005515	protein binding	Xrcc6	IPI	UniProtKB:Q8BJA3	Mouse	MGI:MGI:5500098\|PMID:23685356
Molecular Function	GO:0005515	protein binding	Xrcc6	IPI	UniProtKB:Q06890	Mouse	MGI:MGI:2653704\|PMID:12551933
Molecular Function	GO:0005515	protein binding	Xrcc6	IPI	UniProtKB:Q8BHZ5	Mouse	MGI:MGI:6202149\|PMID:30017584
Molecular Function	GO:0005515	protein binding	Xrcc6	IPI	RGD:3976	Rat	PMID:14576192\|RGD:1300423
Molecular Function	GO:0044877	protein-containing complex binding	XRCC6	IPI	ComplexPortal:CPX-17	Human	PMID:12377759
Molecular Function	GO:0003723	RNA binding	XRCC6	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	XRCC6	HDA		Human	PMID:22681889
Molecular Function	GO:0097110	scaffold protein binding	XRCC6	IPI	UniProtKB:Q8NDB2	Human	PMID:23555801
Molecular Function	GO:0000976	transcription cis-regulatory region binding	XRCC6	IDA		Human	PMID:18809223
Cellular Component	GO:0000781	chromosome, telomeric region	XRCC6	HDA		Human	PMID:19135898
Cellular Component	GO:0005737	cytoplasm	Xrcc6	IDA		Mouse	PMID:12604618
Cellular Component	GO:0005737	cytoplasm	Xrcc6	IDA		Rat	PMID:11175667\|RGD:2317102
Cellular Component	GO:0070418	DNA-dependent protein kinase complex	XRCC6	IPI		Human	PMID:28840859
Cellular Component	GO:0043564	Ku70:Ku80 complex	XRCC6	IPI		Human	PMID:11493912
Cellular Component	GO:0043564	Ku70:Ku80 complex	XRCC6	IDA		Human	PMID:20383123
Cellular Component	GO:0043564	Ku70:Ku80 complex	XRCC6	IDA		Human	PMID:24095731
Cellular Component	GO:0043564	Ku70:Ku80 complex	XRCC6	IDA		Human	PMID:26359349
Cellular Component	GO:0016020	membrane	XRCC6	HDA		Human	PMID:19946888
Cellular Component	GO:0070419	nonhomologous end joining complex	XRCC6	IDA		Human	PMID:20383123
Cellular Component	GO:0070419	nonhomologous end joining complex	XRCC6	IDA		Human	PMID:25941166
Cellular Component	GO:0005730	nucleolus	XRCC6	IDA		Human	PMID:27829214
Cellular Component	GO:0005730	nucleolus	Xrcc6	IDA		Rat	PMID:1639139\|RGD:2317109
Cellular Component	GO:0005654	nucleoplasm	XRCC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Xrcc6	IDA		Mouse	PMID:12604618
Cellular Component	GO:0005634	nucleus	Xrcc6	IDA		Rat	PMID:11966321\|RGD:727219
Cellular Component	GO:0005634	nucleus	Xrcc6	IDA		Rat	PMID:14576192\|RGD:1300423
Cellular Component	GO:0032991	protein-containing complex	XRCC6	IDA		Human	PMID:22504299
Cellular Component	GO:0032991	protein-containing complex	Xrcc6	IDA		Rat	PMID:14576192\|RGD:1300423
Cellular Component	GO:0032993	protein-DNA complex	XRCC6	IDA		Human	PMID:22504299
Cellular Component	GO:0005667	transcription regulator complex	XRCC6	IDA		Human	PMID:12145306
Biological Process	GO:0002218	activation of innate immune response	XRCC6	IDA		Human	PMID:28712728
Biological Process	GO:0007420	brain development	Xrcc6	IEP		Rat	PMID:9674610\|RGD:2317105
Biological Process	GO:0071475	cellular hyperosmotic salinity response	Xrcc6	IDA		Rat	PMID:11175667\|RGD:2317102
Biological Process	GO:0071480	cellular response to gamma radiation	XRCC6	IDA		Human	PMID:26359349
Biological Process	GO:0071481	cellular response to X-ray	Xrcc6	IDA		Rat	PMID:11175667\|RGD:2317102
Biological Process	GO:0006974	DNA damage response	Xrcc6	IMP	MGI:MGI:2179954	Mouse	PMID:15979950
Biological Process	GO:0006302	double-strand break repair	Xrcc6	IMP	MGI:MGI:2179954	Mouse	PMID:11751629
Biological Process	GO:0097680	double-strand break repair via classical nonhomologous end joining	XRCC6	IDA		Human	PMID:24095731
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC6	IMP		Human	PMID:20383123
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	XRCC6	IMP		Human	PMID:26359349
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Xrcc6	IMP	MGI:MGI:2179954	Mouse	PMID:11751629
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	XRCC6	IMP		Human	PMID:8621488
Biological Process	GO:0022008	neurogenesis	Xrcc6	IMP	MGI:MGI:2179954	Mouse	PMID:10716994
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	XRCC6	IDA		Human	PMID:12145306
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	XRCC6	IMP		Human	PMID:18809223
Biological Process	GO:0045621	positive regulation of lymphocyte differentiation	Xrcc6	IMP		Mouse	MGI:MGI:6414739\|PMID:32103174
Biological Process	GO:0050769	positive regulation of neurogenesis	Xrcc6	IMP	MGI:MGI:2179954	Mouse	PMID:10716994
Biological Process	GO:0045860	positive regulation of protein kinase activity	XRCC6	IDA		Human	PMID:22504299
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	XRCC6	IMP		Human	PMID:18809223
Biological Process	GO:0048660	regulation of smooth muscle cell proliferation	XRCC6	IMP		Human	PMID:25852083
Biological Process	GO:0010212	response to ionizing radiation	Xrcc6	IMP	MGI:MGI:2179954	Mouse	PMID:15979950
Biological Process	GO:0010212	response to ionizing radiation	Xrcc6	IMP	MGI:MGI:3625858	Mouse	PMID:21568942
Biological Process	GO:0010212	response to ionizing radiation	xrcc6	IMP	ZFIN:ZDB-MRPHLNO-070920-1	Zfish	PMID:17630212
Biological Process	GO:0010212	response to ionizing radiation	xrcc6	IMP	ZFIN:ZDB-MRPHLNO-070920-2	Zfish	PMID:17630212
Biological Process	GO:0033151	V(D)J recombination	Xrcc6	IMP	MGI:MGI:2179954	Mouse	PMID:10716994

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.