Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes XRN1
  • Mouse genes Xrn1
  • Rat genes Xrn1
  • Zfish genes xrn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xrn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004534	5'-3' RNA exonuclease activity	XRN1	IMP		Human	PMID:26950371
Molecular Function	GO:0004534	5'-3' RNA exonuclease activity	Xrn1	IDA		Mouse	MGI:MGI:86601|PMID:9049243
Molecular Function	GO:0051880	G-quadruplex DNA binding	Xrn1	IDA		Mouse	MGI:MGI:86601|PMID:9049243
Molecular Function	GO:0002151	G-quadruplex RNA binding	Xrn1	IDA		Mouse	MGI:MGI:86601|PMID:9049243
Molecular Function	GO:0005515	protein binding	XRN1	IPI	UniProtKB:P26651	Human	PMID:15687258
Molecular Function	GO:0005515	protein binding	XRN1	IPI	UniProtKB:Q07352	Human	PMID:15687258
Molecular Function	GO:0005515	protein binding	XRN1	IPI	UniProtKB:Q6P2E9	Human	PMID:20584987
Molecular Function	GO:0005515	protein binding	XRN1	IPI	UniProtKB:Q86TB9	Human	PMID:20584987
Molecular Function	GO:0005515	protein binding	XRN1	IPI	UniProtKB:Q7Z2W4	Human	PMID:21876179
Molecular Function	GO:0005515	protein binding	XRN1	IPI	UniProtKB:Q2Q1W2	Human	PMID:23125361
Molecular Function	GO:0005515	protein binding	XRN1	IPI	UniProtKB:Q8IYB7	Human	PMID:23756462
Molecular Function	GO:0005515	protein binding	XRN1	IPI	UniProtKB:Q6P2E9	Human	PMID:24510189
Molecular Function	GO:0005515	protein binding	XRN1	IPI	UniProtKB:Q14147	Human	PMID:25220460
Molecular Function	GO:0005515	protein binding	XRN1	IPI	UniProtKB:Q9H6S0	Human	PMID:29033321
Molecular Function	GO:0005515	protein binding	Xrn1	IPI	UniProtKB:B2RR83	Mouse	MGI:MGI:5911610|PMID:29033321
Molecular Function	GO:0003723	RNA binding	XRN1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	XRN1	HDA		Human	PMID:22681889
Cellular Component	GO:0005737	cytoplasm	Xrn1	IDA		Mouse	MGI:MGI:86601|PMID:9049243
Cellular Component	GO:0005829	cytosol	XRN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Xrn1	IDA		Rat	PMID:25797256|RGD:11085566
Cellular Component	GO:0016020	membrane	XRN1	HDA		Human	PMID:19946888
Cellular Component	GO:0043025	neuronal cell body	Xrn1	IDA		Rat	PMID:25797256|RGD:11085566
Cellular Component	GO:0000932	P-body	Xrn1	IDA		Mouse	PMID:18625844
Cellular Component	GO:0000932	P-body	Xrn1	IDA		Rat	PMID:22590546|RGD:12791034
Cellular Component	GO:0005886	plasma membrane	XRN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045202	synapse	Xrn1	IDA		Rat	PMID:25797256|RGD:11085566
Biological Process	GO:0071409	cellular response to cycloheximide	Xrn1	IEP		Rat	PMID:25797256|RGD:11085566
Biological Process	GO:1905795	cellular response to puromycin	Xrn1	IEP		Rat	PMID:25736288|RGD:12791033
Biological Process	GO:0071044	histone mRNA catabolic process	XRN1	IMP		Human	PMID:18172165
Biological Process	GO:0017148	negative regulation of translation	Xrn1	IMP		Rat	PMID:25797256|RGD:11085566
Biological Process	GO:0071028	nuclear mRNA surveillance	XRN1	IMP		Human	PMID:17545563
Biological Process	GO:0000956	nuclear-transcribed mRNA catabolic process	XRN1	IMP		Human	PMID:17545563
Biological Process	GO:0033574	response to testosterone	Xrn1	IEP		Rat	PMID:25797256|RGD:11085566
Biological Process	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	Xrn1	IDA		Mouse	MGI:MGI:86601|PMID:9049243
Biological Process	GO:0016075	rRNA catabolic process	XRN1	IMP		Human	PMID:20368444

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern