Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes YWHAE
  • Mouse genes Ywhae
  • Rat genes Ywhae
  • Zfish genes ywhae1,ywhae2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ywhae

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	YWHAE	HDA		Human	PMID:25468996
Molecular Function	GO:0005246	calcium channel regulator activity	YWHAE	IDA		Human	PMID:18029012
Molecular Function	GO:0019899	enzyme binding	YWHAE	IPI	UniProtKB:P11388	Human	PMID:10788521
Molecular Function	GO:0019899	enzyme binding	Ywhae	IPI	RGD:1303068	Rat	PMID:8694795|RGD:730124
Molecular Function	GO:0042826	histone deacetylase binding	YWHAE	IPI	UniProtKB:P56524	Human	PMID:10869435
Molecular Function	GO:0042826	histone deacetylase binding	YWHAE	IPI	UniProtKB:Q9UQL6	Human	PMID:10869435
Molecular Function	GO:0042802	identical protein binding	YWHAE	IPI	UniProtKB:P62258	Human	PMID:17085597
Molecular Function	GO:0042802	identical protein binding	YWHAE	IPI	UniProtKB:P62258	Human	PMID:20936779
Molecular Function	GO:0023026	MHC class II protein complex binding	YWHAE	HDA		Human	PMID:20458337
Molecular Function	GO:0051219	phosphoprotein binding	YWHAE	IPI	UniProtKB:Q9UQL6	Human	PMID:10869435
Molecular Function	GO:0050815	phosphoserine residue binding	YWHAE	IPI	UniProtKB:P56524	Human	PMID:10869435
Molecular Function	GO:0015459	potassium channel regulator activity	YWHAE	IDA		Human	PMID:11953308
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:O92972:PRO_0000278742	Human	PMID:10644344
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P56524	Human	PMID:11504882
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P04049	Human	PMID:11697890
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q13671	Human	PMID:11784866
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q99759	Human	PMID:12392720
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P48552	Human	PMID:1266503
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q00613	Human	PMID:12917326
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q99759	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q13322	Human	PMID:15722337
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9GZV5	Human	PMID:16099986
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:O15151	Human	PMID:16227609
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q99469	Human	PMID:16260042
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P63104	Human	PMID:16376338
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q99759	Human	PMID:16407301
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:O15151	Human	PMID:16511560
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:O94921	Human	PMID:16775625
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9NRI5	Human	PMID:17043677
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P27348	Human	PMID:17085597
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P31946	Human	PMID:17085597
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P61981	Human	PMID:17085597
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P56524	Human	PMID:18045992
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9GZV5	Human	PMID:18227151
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:O15151	Human	PMID:18356162
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q14678-2	Human	PMID:18458160
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9Y3M2	Human	PMID:18573912
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9UQC2	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q96PX8	Human	PMID:19640509
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P63104	Human	PMID:20618440
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q5S007	Human	PMID:20642453
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P10398	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P27348	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P31946	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P56524	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P61981	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q04917	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q92934	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9GZV5	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q96AP0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9UKT5	Human	PMID:21242966
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:O00257-3	Human	PMID:21282530
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P27348	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P61981	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P63104	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q92934	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P58340	Human	PMID:22151054
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:O14727	Human	PMID:22246185
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q5S007	Human	PMID:23075850
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P54253	Human	PMID:23275563
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q8WUA7	Human	PMID:23572552
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9NU19	Human	PMID:23572552
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9UBF8	Human	PMID:23572552
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P61588	Human	PMID:23622247
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P56524	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P31946	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P46937	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P46937	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q5S007	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q5S007	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9Y580	Human	PMID:25189701
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9NXR1	Human	PMID:25332407
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q6ZS17-2	Human	PMID:25588844
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P46937	Human	PMID:25751139
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P04049	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P10398	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P54253	Human	PMID:25959826
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P63104	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q04917	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:O15553	Human	PMID:27030597
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9Y3M2	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P27348	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P61981	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q04917	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q13671	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q99469	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P09622	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P21796	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P36957	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q53GT1	Human	PMID:29769719
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q3U182	Human	PMID:30611118
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q68ED7	Human	PMID:30611118
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q6UUV7	Human	PMID:30611118
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q91X84	Human	PMID:30611118
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q5S007	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q9NRI5	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P04049	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P27348	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P31946	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P61981	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P63104	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q04917	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q13671	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q92934	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P56524-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q7L804	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:Q86Z20	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P04049	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P10398	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	YWHAE	IPI	UniProtKB:P04049	Human	PMID:7644510
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:Q8C2B3	Mouse	MGI:MGI:5508292|PMID:11585834
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:Q8C2B3	Mouse	MGI:MGI:5512846|PMID:16956611
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:P85037	Mouse	MGI:MGI:6163926|PMID:29861159
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:Q5S006	Mouse	MGI:MGI:6355873|PMID:31046837
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:Q60760	Mouse	MGI:MGI:3579938|PMID:15722337
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:Q8C2B3	Mouse	MGI:MGI:5508274|PMID:15166223
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:Q5S006	Mouse	MGI:MGI:5487519|PMID:21390248
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:Q8CHQ0	Mouse	MGI:MGI:5285136|PMID:21242966
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:O35244	Mouse	MGI:MGI:5520041|PMID:21346153
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:Q64163-4	Mouse	MGI:MGI:5508255|PMID:16482218
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	PR:Q9ERR1	Mouse	PMID:18331715
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	PR:Q9ERR1	Mouse	PMID:12796778
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	PR:Q9DBB1	Mouse	PMID:15284227
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	RGD:3717	Rat	PMID:16679322|RGD:1581353
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:P67828	Rat	PMID:19860830|RGD:8554057
Molecular Function	GO:0005515	protein binding	Ywhae	IPI	UniProtKB:Q9UKT5	Rat	PMID:21242966|RGD:8554619
Molecular Function	GO:0019904	protein domain specific binding	Ywhae	IDA		Mouse	PMID:12446771
Molecular Function	GO:0046982	protein heterodimerization activity	YWHAE	IPI	UniProtKB:Q04917	Human	PMID:11953308
Molecular Function	GO:0019903	protein phosphatase binding	Ywhae	IPI	PR:000045550	Mouse	PMID:23326474
Molecular Function	GO:0044877	protein-containing complex binding	Ywhae	IPI	RGD:620331|RGD:631359|RGD:621235|RGD:1303035	Rat	PMID:17202468|RGD:4107038
Molecular Function	GO:0003723	RNA binding	YWHAE	HDA		Human	PMID:22658674
Molecular Function	GO:0097110	scaffold protein binding	YWHAE	IPI	UniProtKB:Q61097	Human	PMID:10409742
Molecular Function	GO:0044325	transmembrane transporter binding	YWHAE	IPI	UniProtKB:Q12809	Human	PMID:11953308
Molecular Function	GO:0044325	transmembrane transporter binding	YWHAE	IPI	UniProtKB:P20020	Human	PMID:18029012
Molecular Function	GO:0044325	transmembrane transporter binding	YWHAE	IPI	UniProtKB:Q16720	Human	PMID:18029012
Molecular Function	GO:0031625	ubiquitin protein ligase binding	YWHAE	IPI	UniProtKB:O60260	Human	PMID:19725078
Cellular Component	GO:0030424	axon	Ywhae	IDA		Rat	PMID:17202468|RGD:4107038
Cellular Component	GO:0090724	central region of growth cone	Ywhae	IDA		Rat	PMID:17202468|RGD:4107038
Cellular Component	GO:0005737	cytoplasm	YWHAE	IDA		Human	PMID:12917326
Cellular Component	GO:0005737	cytoplasm	Ywhae	IDA		Mouse	PMID:23326474
Cellular Component	GO:0005829	cytosol	YWHAE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Ywhae	IDA		Rat	PMID:17202468|RGD:4107038
Cellular Component	GO:0070062	extracellular exosome	YWHAE	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	YWHAE	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	YWHAE	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	YWHAE	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	YWHAE	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Ywhae	EXP		Rat	PMID:19477150|RGD:13702300
Cellular Component	GO:0098978	glutamatergic synapse	Ywhae	IDA		Rat	PMID:19477150|RGD:13702300
Cellular Component	GO:0005871	kinesin complex	Ywhae	IDA		Rat	PMID:17202468|RGD:4107038
Cellular Component	GO:0016020	membrane	YWHAE	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	Ywhae	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005634	nucleus	YWHAE	IDA		Human	PMID:12917326
Cellular Component	GO:0005886	plasma membrane	YWHAE	IDA		Human	PMID:18029012
Cellular Component	GO:0045202	synapse	Ywhae	IDA		Rat	PMID:7964746|RGD:13702149
Biological Process	GO:0034605	cellular response to heat	YWHAE	IDA		Human	PMID:12917326
Biological Process	GO:0021987	cerebral cortex development	Ywhae	IMP	MGI:MGI:2667341	Mouse	PMID:12796778
Biological Process	GO:0021766	hippocampus development	Ywhae	IMP	MGI:MGI:2667341	Mouse	PMID:12796778
Biological Process	GO:0000165	MAPK cascade	YWHAE	IDA		Human	PMID:12917326
Biological Process	GO:1905913	negative regulation of calcium ion export across plasma membrane	YWHAE	IDA		Human	PMID:18029012
Biological Process	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	YWHAE	IDA		Human	PMID:18029012
Biological Process	GO:1902309	negative regulation of peptidyl-serine dephosphorylation	YWHAE	IDA		Human	PMID:11953308
Biological Process	GO:0035308	negative regulation of protein dephosphorylation	Ywhae	IDA		Mouse	PMID:12796778
Biological Process	GO:0001764	neuron migration	Ywhae	IGI	MGI:MGI:109520	Mouse	PMID:12796778
Biological Process	GO:0001764	neuron migration	Ywhae	IMP	MGI:MGI:2667341	Mouse	PMID:12796778
Biological Process	GO:0046827	positive regulation of protein export from nucleus	YWHAE	IDA		Human	PMID:12917326
Biological Process	GO:0034504	protein localization to nucleus	YWHAE	IMP		Human	PMID:29769719
Biological Process	GO:0006605	protein targeting	Ywhae	IDA		Mouse	PMID:12446771
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	YWHAE	IDA		Human	PMID:18029012
Biological Process	GO:0060306	regulation of membrane repolarization	YWHAE	IDA		Human	PMID:11953308
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Ywhae	EXP		Rat	PMID:19477150|RGD:13702300
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Ywhae	IDA		Rat	PMID:19477150|RGD:13702300
Biological Process	GO:1901016	regulation of potassium ion transmembrane transporter activity	YWHAE	IDA		Human	PMID:11953308
Biological Process	GO:0021762	substantia nigra development	YWHAE	HEP		Human	PMID:22926577

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern