Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Zap70

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ZAP70
- Mouse genes Zap70
- Rat genes Zap70
- Zfish genes zap70
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zap70

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Zap70	IDA		Mouse	PMID:8798454
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ZAP70	IDA		Human	PMID:12447358
Molecular Function	GO:0001784	phosphotyrosine residue binding	ZAP70	IMP		Human	PMID:12051764
Molecular Function	GO:0001784	phosphotyrosine residue binding	ZAP70	IPI	UniProtKB:Q96P31	Human	PMID:12051764
Molecular Function	GO:0001784	phosphotyrosine residue binding	Zap70	IPI	PR:P22646	Mouse	PMID:8196616
Molecular Function	GO:0001784	phosphotyrosine residue binding	Zap70	IPI	PR:P11942	Mouse	PMID:8196616
Molecular Function	GO:0001784	phosphotyrosine residue binding	Zap70	IPI	MGI:MGI:88334	Mouse	PMID:8196616
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P06239	Human	PMID:10318843
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P20963	Human	PMID:10704231
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P20963	Human	PMID:10752619
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P07766	Human	PMID:11855827
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:Q9H6Q3	Human	PMID:11891219
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:Q8IWV1	Human	PMID:12359715
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:O43561	Human	PMID:12646565
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P20963	Human	PMID:15832366
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P06239	Human	PMID:16461343
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:Q9Y2R2	Human	PMID:16461343
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:Q96P31	Human	PMID:19843936
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P20963	Human	PMID:21957439
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P22681	Human	PMID:22266821
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:Q8N1K5-1	Human	PMID:23460737
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:Q8BGG7	Human	PMID:24256567
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P20963	Human	PMID:26783323
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P20963	Human	PMID:7509083
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P20963	Human	PMID:7528772
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P07766	Human	PMID:7761456
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P20963	Human	PMID:8648092
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P20963	Human	PMID:8901551
Molecular Function	GO:0005515	protein binding	ZAP70	IPI	UniProtKB:P20963	Human	PMID:9185620
Molecular Function	GO:0005515	protein binding	Zap70	IPI	UniProtKB:P24161	Mouse	MGI:MGI:5532887\|PMID:24034254
Molecular Function	GO:0005515	protein binding	Zap70	IPI	UniProtKB:P24161	Mouse	MGI:MGI:5568870\|PMID:24584089
Molecular Function	GO:0005515	protein binding	Zap70	IPI	UniProtKB:Q9D3G9	Mouse	MGI:MGI:3686961\|PMID:17028588
Molecular Function	GO:0005515	protein binding	Zap70	IPI	PR:P70315	Mouse	PMID:15699074
Molecular Function	GO:0005515	protein binding	Zap70	IPI	PR:Q811D0	Mouse	PMID:15699074
Molecular Function	GO:0005515	protein binding	Zap70	IPI	PR:P06240	Mouse	PMID:16501569
Molecular Function	GO:0005515	protein binding	Zap70	IPI	PR:P22682	Mouse	PMID:8551236
Molecular Function	GO:0004672	protein kinase activity	Zap70	IDA		Mouse	PMID:14738763
Molecular Function	GO:0004713	protein tyrosine kinase activity	ZAP70	IDA		Human	PMID:15292186
Molecular Function	GO:0004713	protein tyrosine kinase activity	Zap70	IDA		Mouse	PMID:8798454
Molecular Function	GO:0004713	protein tyrosine kinase activity	Zap70	IDA		Mouse	PMID:9169414
Molecular Function	GO:0004713	protein tyrosine kinase activity	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839
Cellular Component	GO:0005911	cell-cell junction	Zap70	IDA		Mouse	PMID:23793062
Cellular Component	GO:0005737	cytoplasm	Zap70	IDA		Mouse	MGI:MGI:3686961\|PMID:17028588
Cellular Component	GO:0005829	cytosol	Zap70	IDA		Mouse	PMID:15599401
Cellular Component	GO:0005829	cytosol	Zap70	IDA		Mouse	PMID:9182527
Cellular Component	GO:0001772	immunological synapse	Zap70	IDA		Mouse	MGI:MGI:3686961\|PMID:17028588
Cellular Component	GO:0016020	membrane	Zap70	IDA		Mouse	PMID:15599401
Cellular Component	GO:0045121	membrane raft	ZAP70	IDA		Human	PMID:12150984
Cellular Component	GO:0005886	plasma membrane	ZAP70	IDA		Human	PMID:12150984
Cellular Component	GO:0005886	plasma membrane	Zap70	IDA		Mouse	MGI:MGI:3686961\|PMID:17028588
Cellular Component	GO:0042101	T cell receptor complex	ZAP70	IDA		Human	PMID:8176201
Biological Process	GO:0046632	alpha-beta T cell differentiation	Zap70	IMP	MGI:MGI:2677447	Mouse	PMID:7630421
Biological Process	GO:0046632	alpha-beta T cell differentiation	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839
Biological Process	GO:0046632	alpha-beta T cell differentiation	Zap70	IGI	MGI:MGI:99515	Mouse	PMID:9275205
Biological Process	GO:0043366	beta selection	Zap70	IGI	MGI:MGI:99515	Mouse	PMID:9275205
Biological Process	GO:0019722	calcium-mediated signaling	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839
Biological Process	GO:0019722	calcium-mediated signaling	Zap70	IMP	MGI:MGI:2677447	Mouse	PMID:7630421
Biological Process	GO:0006955	immune response	ZAP70	IDA		Human	PMID:1423621
Biological Process	GO:0035556	intracellular signal transduction	Zap70	IMP	MGI:MGI:2677447	Mouse	PMID:7630421
Biological Process	GO:0001946	lymphangiogenesis	zap70	IGI	ZFIN:ZDB-GENE-040702-3,ZFIN:ZDB-GENE-050522-257	Zfish	PMID:20096681
Biological Process	GO:0001946	lymphangiogenesis	zap70	IMP	ZFIN:ZDB-MRPHLNO-100407-4	Zfish	PMID:20096681
Biological Process	GO:0045060	negative thymic T cell selection	Zap70	IMP	MGI:MGI:2677447	Mouse	PMID:7630421
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ZAP70	IDA		Human	PMID:22732588
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ZAP70	IMP		Human	PMID:23620790
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Zap70	IDA		Mouse	PMID:8798454
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Zap70	IMP	MGI:MGI:2677447	Mouse	PMID:7630421
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Zap70	IGI	MGI:MGI:99515	Mouse	PMID:9275205
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	Zap70	IGI	MGI:MGI:99515	Mouse	PMID:9275205
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Zap70	IMP	MGI:MGI:2677447	Mouse	PMID:7630421
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	zap70	IGI	ZFIN:ZDB-GENE-040702-3,ZFIN:ZDB-GENE-050522-257	Zfish	PMID:20096681
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	zap70	IMP	ZFIN:ZDB-MRPHLNO-100407-3	Zfish	PMID:20096681
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	zap70	IMP	ZFIN:ZDB-MRPHLNO-100407-4	Zfish	PMID:20096681
Biological Process	GO:0045582	positive regulation of T cell differentiation	ZAP70	IDA		Human	PMID:7630421
Biological Process	GO:0045582	positive regulation of T cell differentiation	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839
Biological Process	GO:0045582	positive regulation of T cell differentiation	Zap70	IMP	MGI:MGI:2677447	Mouse	PMID:9208839
Biological Process	GO:0045059	positive thymic T cell selection	ZAP70	IDA		Human	PMID:7630421
Biological Process	GO:0045059	positive thymic T cell selection	Zap70	IMP	MGI:MGI:2677447	Mouse	PMID:7630421
Biological Process	GO:0046777	protein autophosphorylation	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839
Biological Process	GO:0046777	protein autophosphorylation	Zap70	IDA		Mouse	PMID:8798454
Biological Process	GO:0006468	protein phosphorylation	ZAP70	IDA		Human	PMID:12447358
Biological Process	GO:0006468	protein phosphorylation	Zap70	IDA		Mouse	PMID:9169414
Biological Process	GO:0030217	T cell differentiation	Zap70	IMP	MGI:MGI:2677447	Mouse	PMID:9208839
Biological Process	GO:0030217	T cell differentiation	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839
Biological Process	GO:0050852	T cell receptor signaling pathway	ZAP70	IDA		Human	PMID:9489702
Biological Process	GO:0050852	T cell receptor signaling pathway	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839
Biological Process	GO:0045061	thymic T cell selection	Zap70	IMP	MGI:MGI:2677447	Mouse	PMID:9208839
Biological Process	GO:0045061	thymic T cell selection	Zap70	IMP	MGI:MGI:3526403	Mouse	PMID:9208839

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.