Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Zc3h12a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ZC3H12A
- Mouse genes Zc3h12a
- Rat genes Zc3h12a
- Zfish genes zc3h12ab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zc3h12a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	ZC3H12A	IDA		Human	PMID:18364357
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	ZC3H12A	IMP		Human	PMID:25861989
Molecular Function	GO:0003677	DNA binding	ZC3H12A	IDA		Human	PMID:18364357
Molecular Function	GO:0035198	miRNA binding	ZC3H12A	IDA		Human	PMID:22055188
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding	Zc3h12a	IDA		Mouse	MGI:MGI:3842851\|PMID:19322177
Molecular Function	GO:0003730	mRNA 3'-UTR binding	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Molecular Function	GO:0003730	mRNA 3'-UTR binding	Zc3h12a	IDA		Mouse	MGI:MGI:5706909\|PMID:23185455
Molecular Function	GO:0003730	mRNA 3'-UTR binding	Zc3h12a	IDA		Mouse	MGI:MGI:5706859\|PMID:26000482
Molecular Function	GO:0003729	mRNA binding	ZC3H12A	IDA		Human	PMID:19909337
Molecular Function	GO:0003729	mRNA binding	Zc3h12a	EXP		Mouse	MGI:MGI:7310021\|PMID:26927947
Molecular Function	GO:0004518	nuclease activity	Zc3h12a	IMP		Mouse	MGI:MGI:6142401\|PMID:25282160
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q9NZD4	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q9Y297	Human	PMID:21900206
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:O43187	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:P84022	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q9Y297	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q14694	Human	PMID:24270572
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q9Y297	Human	PMID:24270572
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q9Y6K9	Human	PMID:24270572
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q7Z4N8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q9NZD4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q14694	Human	PMID:25861989
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q92844	Human	PMID:25861989
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q9Y4K3	Human	PMID:25861989
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q9Y6K9	Human	PMID:25861989
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:A2A288	Human	PMID:26134560
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q8NDV7	Human	PMID:26134560
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:P59910	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZC3H12A	IPI	UniProtKB:Q7Z4N8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Zc3h12a	IPI	UniProtKB:Q92900	Mouse	MGI:MGI:5751631\|PMID:26255671
Molecular Function	GO:0005515	protein binding	Zc3h12a	IPI	UniProtKB:Q92900	Mouse	MGI:MGI:5706859\|PMID:26000482
Molecular Function	GO:0005515	protein binding	Zc3h12a	IPI	UniProtKB:O14920\|UniProtKB:P51617	Mouse	MGI:MGI:5300871\|PMID:22037600
Molecular Function	GO:0043022	ribosome binding	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Molecular Function	GO:0003723	RNA binding	ZC3H12A	IDA		Human	PMID:23355615
Molecular Function	GO:0004521	RNA endonuclease activity	Zc3h12a	IDA		Mouse	MGI:MGI:5706859\|PMID:26000482
Molecular Function	GO:0004521	RNA endonuclease activity	Zc3h12a	IDA		Mouse	MGI:MGI:5706911\|PMID:22055188
Molecular Function	GO:0004521	RNA endonuclease activity	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Molecular Function	GO:0004532	RNA exonuclease activity	Zc3h12a	IDA		Mouse	MGI:MGI:3842851\|PMID:19322177
Molecular Function	GO:0004540	RNA nuclease activity	ZC3H12A	IDA		Human	PMID:23355615
Molecular Function	GO:0035613	RNA stem-loop binding	Zc3h12a	IDA		Mouse	MGI:MGI:5706859\|PMID:26000482
Molecular Function	GO:0035613	RNA stem-loop binding	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Molecular Function	GO:0035613	RNA stem-loop binding	Zc3h12a	IDA		Mouse	MGI:MGI:5706909\|PMID:23185455
Cellular Component	GO:0005737	cytoplasm	ZC3H12A	IDA		Human	PMID:18178554
Cellular Component	GO:0005737	cytoplasm	ZC3H12A	IDA		Human	PMID:19909337
Cellular Component	GO:0005737	cytoplasm	Zc3h12a	IDA		Mouse	MGI:MGI:3842851\|PMID:19322177
Cellular Component	GO:0005737	cytoplasm	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Cellular Component	GO:0005737	cytoplasm	Zc3h12a	IDA		Mouse	MGI:MGI:5706859\|PMID:26000482
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ZC3H12A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005856	cytoskeleton	ZC3H12A	IDA		Human	PMID:19909337
Cellular Component	GO:0042406	extrinsic component of endoplasmic reticulum membrane	Zc3h12a	IDA		Mouse	MGI:MGI:5706859\|PMID:26000482
Cellular Component	GO:0042406	extrinsic component of endoplasmic reticulum membrane	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Cellular Component	GO:0005654	nucleoplasm	ZC3H12A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ZC3H12A	IDA		Human	PMID:16574901
Cellular Component	GO:0005634	nucleus	Zc3h12a	IDA		Mouse	MGI:MGI:3842851\|PMID:19322177
Cellular Component	GO:0005634	nucleus	Zc3h12a	IDA		Mouse	MGI:MGI:5706916\|PMID:16574901
Cellular Component	GO:0000932	P-body	ZC3H12A	IDA		Human	PMID:22055188
Cellular Component	GO:0000932	P-body	ZC3H12A	IDA		Human	PMID:26134560
Cellular Component	GO:0032991	protein-containing complex	ZC3H12A	IDA		Human	PMID:25861989
Cellular Component	GO:0005791	rough endoplasmic reticulum	Zc3h12a	IDA		Mouse	MGI:MGI:5706859\|PMID:26000482
Cellular Component	GO:0005791	rough endoplasmic reticulum	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	ZC3H12A	IDA		Human	PMID:19909337
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	Zc3h12a	IDA		Mouse	MGI:MGI:5706909\|PMID:23185455
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	Zc3h12a	IDA		Mouse	MGI:MGI:5706859\|PMID:26000482
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	Zc3h12a	IDA		Mouse	MGI:MGI:3842851\|PMID:19322177
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	Zc3h12a	IDA		Mouse	MGI:MGI:5707103\|PMID:26134560
Biological Process	GO:1990869	cellular response to chemokine	ZC3H12A	IDA		Human	PMID:16574901
Biological Process	GO:1990869	cellular response to chemokine	ZC3H12A	IDA		Human	PMID:18364357
Biological Process	GO:1990869	cellular response to chemokine	Zc3h12a	IDA		Mouse	MGI:MGI:5706914\|PMID:19666473
Biological Process	GO:0042149	cellular response to glucose starvation	Zc3h12a	IDA		Mouse	MGI:MGI:5297619\|PMID:21971051
Biological Process	GO:0071347	cellular response to interleukin-1	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Biological Process	GO:1904637	cellular response to ionomycin	Zc3h12a	IDA		Mouse	MGI:MGI:5706909\|PMID:23185455
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ZC3H12A	IDA		Human	PMID:18178554
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ZC3H12A	IDA		Human	PMID:19909337
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ZC3H12A	IDA		Human	PMID:22055188
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ZC3H12A	IMP		Human	PMID:25861989
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Zc3h12a	IDA		Mouse	MGI:MGI:5706859\|PMID:26000482
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Zc3h12a	IDA		Mouse	MGI:MGI:3842851\|PMID:19322177
Biological Process	GO:0034599	cellular response to oxidative stress	Zc3h12a	IDA		Mouse	MGI:MGI:5297619\|PMID:21971051
Biological Process	GO:1903936	cellular response to sodium arsenite	Zc3h12a	IDA		Mouse	MGI:MGI:5297619\|PMID:21971051
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ZC3H12A	IDA		Human	PMID:19909337
Biological Process	GO:0098586	cellular response to virus	ZC3H12A	IDA		Human	PMID:23355615
Biological Process	GO:0006974	DNA damage response	ZC3H12A	IMP		Human	PMID:25861989
Biological Process	GO:0002757	immune response-activating signaling pathway	ZC3H12A	IDA		Human	PMID:19909337
Biological Process	GO:0010587	miRNA catabolic process	ZC3H12A	IDA		Human	PMID:22055188
Biological Process	GO:0044828	negative regulation by host of viral genome replication	ZC3H12A	IDA		Human	PMID:23355615
Biological Process	GO:0055118	negative regulation of cardiac muscle contraction	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:0010629	negative regulation of gene expression	ZC3H12A	IDA		Human	PMID:18178554
Biological Process	GO:0010629	negative regulation of gene expression	Zc3h12a	IMP		Mouse	MGI:MGI:5486545\|PMID:18178554
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ZC3H12A	IMP		Human	PMID:25861989
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ZC3H12A	IDA		Human	PMID:18178554
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ZC3H12A	IDA		Human	PMID:18178554
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ZC3H12A	IDA		Human	PMID:18178554
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Zc3h12a	IDA		Mouse	MGI:MGI:5297619\|PMID:21971051
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	Zc3h12a	IMP		Mouse	MGI:MGI:6142401\|PMID:25282160
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ZC3H12A	IDA		Human	PMID:18178554
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:0032689	negative regulation of type II interferon production	Zc3h12a	IDA		Mouse	MGI:MGI:5142149\|PMID:21616078
Biological Process	GO:0000294	nuclear-transcribed mRNA catabolic process, RNase MRP-dependent	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Biological Process	GO:0045766	positive regulation of angiogenesis	ZC3H12A	IDA		Human	PMID:18364357
Biological Process	GO:0045766	positive regulation of angiogenesis	ZC3H12A	IMP		Human	PMID:24048733
Biological Process	GO:0010508	positive regulation of autophagy	ZC3H12A	IDA		Human	PMID:22739135
Biological Process	GO:0010508	positive regulation of autophagy	Zc3h12a	IMP		Mouse	MGI:MGI:5487497\|PMID:22739135
Biological Process	GO:0010942	positive regulation of cell death	ZC3H12A	IDA		Human	PMID:16574901
Biological Process	GO:0002230	positive regulation of defense response to virus by host	ZC3H12A	IDA		Human	PMID:23355615
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ZC3H12A	IDA		Human	PMID:18364357
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis	Zc3h12a	IDA		Mouse	MGI:MGI:5297619\|PMID:21971051
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ZC3H12A	IDA		Human	PMID:22739135
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Zc3h12a	IDA		Mouse	MGI:MGI:5706914\|PMID:19666473
Biological Process	GO:0010628	positive regulation of gene expression	ZC3H12A	IDA		Human	PMID:22739135
Biological Process	GO:0010884	positive regulation of lipid storage	ZC3H12A	IDA		Human	PMID:22739135
Biological Process	GO:0010884	positive regulation of lipid storage	Zc3h12a	IMP		Mouse	MGI:MGI:5487497\|PMID:22739135
Biological Process	GO:2000627	positive regulation of miRNA catabolic process	ZC3H12A	IDA		Human	PMID:24048733
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	ZC3H12A	IDA		Human	PMID:19909337
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	Zc3h12a	IDA		Mouse	MGI:MGI:5706859\|PMID:26000482
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	Zc3h12a	IDA		Mouse	MGI:MGI:3842851\|PMID:19322177
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	Zc3h12a	IDA		Mouse	MGI:MGI:5706909\|PMID:23185455
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	ZC3H12A	IDA		Human	PMID:24048733
Biological Process	GO:1903003	positive regulation of protein deubiquitination	ZC3H12A	IMP		Human	PMID:25861989
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ZC3H12A	IDA		Human	PMID:24048733
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ZC3H12A	IDA		Human	PMID:22739135
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ZC3H12A	IDA		Human	PMID:16574901
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ZC3H12A	IDA		Human	PMID:18364357
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zc3h12a	IDA		Mouse	MGI:MGI:5706914\|PMID:19666473
Biological Process	GO:0051259	protein complex oligomerization	ZC3H12A	IDA		Human	PMID:22055188
Biological Process	GO:0051259	protein complex oligomerization	ZC3H12A	IDA		Human	PMID:23355615
Biological Process	GO:0016579	protein deubiquitination	ZC3H12A	IDA		Human	PMID:24048733
Biological Process	GO:0010468	regulation of gene expression	ZC3H12A	IDA		Human	PMID:24048733
Biological Process	GO:0090501	RNA phosphodiester bond hydrolysis	Zc3h12a	IDA		Mouse	MGI:MGI:3842851\|PMID:19322177
Biological Process	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	Zc3h12a	IDA		Mouse	MGI:MGI:5706859\|PMID:26000482
Biological Process	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	Zc3h12a	IDA		Mouse	MGI:MGI:5751631\|PMID:26255671
Biological Process	GO:0050852	T cell receptor signaling pathway	Zc3h12a	IMP		Mouse	MGI:MGI:6142401\|PMID:25282160
Biological Process	GO:0050852	T cell receptor signaling pathway	Zc3h12a	IDA		Mouse	MGI:MGI:5706909\|PMID:23185455

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/27/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.