Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZEB1
  • Mouse genes Zeb1
  • Rat genes Zeb1
  • Zfish genes zeb1a,zeb1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zeb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Zeb1	IDA		Mouse	PMID:17392792
Molecular Function	GO:0003682	chromatin binding	Zeb1	IDA		Mouse	PMID:16824956
Molecular Function	GO:0003682	chromatin binding	Zeb1	IDA		Rat	PMID:16824956|RGD:2325877
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZEB1	IDA		Human	PMID:23765923
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZEB1	IDA		Human	PMID:23814079
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Zeb1	IDA		Mouse	PMID:24735878
Molecular Function	GO:0003690	double-stranded DNA binding	Zeb1	IDA		Rat	PMID:8769566|RGD:730026
Molecular Function	GO:0070888	E-box binding	Zeb1	IDA		Mouse	MGI:MGI:4830798|PMID:20346398
Molecular Function	GO:0005515	protein binding	ZEB1	IPI	UniProtKB:P51532	Human	PMID:20418909
Molecular Function	GO:0005515	protein binding	Zeb1	IPI	UniProtKB:O88712	Mouse	MGI:MGI:4939879|PMID:21224849
Molecular Function	GO:0005515	protein binding	Zeb1	IPI	PR:Q6ZQ88	Mouse	PMID:17392792
Molecular Function	GO:0005515	protein binding	Zeb1	IPI	PR:Q9JM73	Mouse	PMID:16824956
Molecular Function	GO:0005515	protein binding	Zeb1	IPI	RGD:3032	Rat	PMID:16824956|RGD:2325877
Molecular Function	GO:0043565	sequence-specific DNA binding	Zeb1	IDA		Rat	PMID:15226419|RGD:2325878
Cellular Component	GO:0005829	cytosol	ZEB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ZEB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ZEB1	IDA		Human	PMID:20418909
Cellular Component	GO:0005634	nucleus	ZEB1	IDA		Human	PMID:23814079
Cellular Component	GO:0005634	nucleus	ZEB1	IDA		Human	PMID:25190660
Cellular Component	GO:0005634	nucleus	Zeb1	IDA		Mouse	MGI:MGI:4830798|PMID:20346398
Cellular Component	GO:0005634	nucleus	Zeb1	IDA		Mouse	PMID:14643678
Cellular Component	GO:0005634	nucleus	Zeb1	IDA		Rat	PMID:15226419|RGD:2325878
Biological Process	GO:0048513	animal organ development	Zeb1	IMP	MGI:MGI:1861230	Mouse	PMID:11681996
Biological Process	GO:0051216	cartilage development	Zeb1	IMP	MGI:MGI:1857799	Mouse	PMID:9389660
Biological Process	GO:0048469	cell maturation	zeb1a	IMP	ZFIN:ZDB-MRPHLNO-170327-1	Zfish	PMID:28049660
Biological Process	GO:0008283	cell population proliferation	Zeb1	IMP	MGI:MGI:1857515	Mouse	PMID:18436818
Biological Process	GO:0071230	cellular response to amino acid stimulus	Zeb1	IDA		Mouse	PMID:20548288
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Zeb1	IEP		Rat	PMID:16824956|RGD:2325877
Biological Process	GO:0007417	central nervous system development	Zeb1	IGI	MGI:MGI:1344407	Mouse	PMID:16598713
Biological Process	GO:0090103	cochlea morphogenesis	Zeb1	IMP	MGI:MGI:1861230	Mouse	PMID:21980308
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Zeb1	IMP	MGI:MGI:1857515	Mouse	PMID:18436818
Biological Process	GO:0048598	embryonic morphogenesis	Zeb1	IGI	MGI:MGI:1344407	Mouse	PMID:16598713
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Zeb1	IMP	MGI:MGI:1857799	Mouse	PMID:9389660
Biological Process	GO:0050673	epithelial cell proliferation	Zeb1	IMP	MGI:MGI:1857515	Mouse	PMID:18436818
Biological Process	GO:0030900	forebrain development	Zeb1	IEP		Rat	PMID:11731009|RGD:2325879
Biological Process	GO:0014831	gastro-intestinal system smooth muscle contraction	zeb1a	IMP	ZFIN:ZDB-MRPHLNO-170327-1	Zfish	PMID:28049660
Biological Process	GO:0007369	gastrulation	zeb1b	IMP	ZFIN:ZDB-MRPHLNO-130910-1	Zfish	PMID:20036349
Biological Process	GO:0043616	keratinocyte proliferation	Zeb1	IMP	MGI:MGI:1857515	Mouse	PMID:18436818
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ZEB1	IMP		Human	PMID:12937339
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ZEB1	IDA		Human	PMID:20418909
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Zeb1	IDA		Mouse	MGI:MGI:4830798|PMID:20346398
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	ZEB1	IMP		Human	PMID:23765923
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	Zeb1	IMP		Mouse	PMID:18192284
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Zeb1	IMP	MGI:MGI:1857515	Mouse	PMID:18436818
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	Zeb1	IMP	MGI:MGI:1857515	Mouse	PMID:18436818
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ZEB1	IDA		Human	PMID:23765923
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ZEB1	IDA		Human	PMID:23814079
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Zeb1	IMP		Mouse	PMID:17392792
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Zeb1	IDA		Rat	PMID:11476947|RGD:2325880
Biological Process	GO:0007389	pattern specification process	Zeb1	IMP	MGI:MGI:1857799	Mouse	PMID:9389660
Biological Process	GO:0045666	positive regulation of neuron differentiation	Zeb1	IDA		Mouse	MGI:MGI:4830798|PMID:20346398
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zeb1	IDA		Mouse	PMID:16824956
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zeb1	IGI	MGI:MGI:1201674	Mouse	PMID:16824956
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zeb1	IGI	MGI:MGI:106658	Mouse	PMID:16824956
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zeb1	IGI	MGI:MGI:894293	Mouse	PMID:16824956
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zeb1	IMP		Rat	PMID:16824956|RGD:2325877
Biological Process	GO:2000145	regulation of cell motility	zeb1b	IGI	ZFIN:ZDB-MRPHLNO-050413-1,ZFIN:ZDB-MRPHLNO-120823-1,ZFIN:ZDB-MRPHLNO-120823-2,ZFIN:ZDB-MRPHLNO-120823-3,ZFIN:ZDB-MRPHLNO-120823-4,ZFIN:ZDB-MRPHLNO-120823-5	Zfish	PMID:22705393
Biological Process	GO:0070587	regulation of cell-cell adhesion involved in gastrulation	zeb1b	IGI	ZFIN:ZDB-MRPHLNO-130801-1,ZFIN:ZDB-MRPHLNO-130801-2	Zfish	PMID:23667256
Biological Process	GO:0070587	regulation of cell-cell adhesion involved in gastrulation	zeb1a	IGI	ZFIN:ZDB-MRPHLNO-130801-1,ZFIN:ZDB-MRPHLNO-130801-2	Zfish	PMID:23667256
Biological Process	GO:0010470	regulation of gastrulation	zeb1b	IGI	ZFIN:ZDB-MRPHLNO-130801-1,ZFIN:ZDB-MRPHLNO-130801-2	Zfish	PMID:23667256
Biological Process	GO:0010470	regulation of gastrulation	zeb1a	IGI	ZFIN:ZDB-MRPHLNO-130801-1,ZFIN:ZDB-MRPHLNO-130801-2	Zfish	PMID:23667256
Biological Process	GO:0010464	regulation of mesenchymal cell proliferation	Zeb1	IMP		Mouse	PMID:18192284
Biological Process	GO:0051150	regulation of smooth muscle cell differentiation	Zeb1	IMP		Mouse	PMID:16824956
Biological Process	GO:0033081	regulation of T cell differentiation in thymus	Zeb1	IMP	MGI:MGI:1857799	Mouse	PMID:9389660
Biological Process	GO:0033081	regulation of T cell differentiation in thymus	Zeb1	IMP	MGI:MGI:1857515	Mouse	PMID:9126927
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	Zeb1	IGI	MGI:MGI:1201674	Mouse	PMID:16824956
Biological Process	GO:0014823	response to activity	Zeb1	IEP		Rat	PMID:19366873|RGD:2325875
Biological Process	GO:0031667	response to nutrient levels	Zeb1	IEP		Rat	PMID:19366873|RGD:2325875
Biological Process	GO:0048752	semicircular canal morphogenesis	Zeb1	IMP	MGI:MGI:1861230	Mouse	PMID:21980308
Biological Process	GO:0048745	smooth muscle tissue development	zeb1a	IMP	ZFIN:ZDB-MRPHLNO-170327-1	Zfish	PMID:28049660
Biological Process	GO:0090130	tissue migration	zeb1a	IMP	ZFIN:ZDB-MRPHLNO-170327-1	Zfish	PMID:28049660

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern