Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Zeb2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ZEB2
- Mouse genes Zeb2
- Rat genes Zeb2
- Zfish genes zeb2a,zeb2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zeb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2668659	Mouse	PMID:25741725
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZEB2	IDA		Human	PMID:20516212
Molecular Function	GO:0005515	protein binding	ZEB2	IPI	UniProtKB:O94776	Human	PMID:26028330
Molecular Function	GO:0005515	protein binding	ZEB2	IPI	UniProtKB:Q13330	Human	PMID:26028330
Molecular Function	GO:0005515	protein binding	ZEB2	IPI	UniProtKB:Q96KQ7	Human	PMID:26028330
Molecular Function	GO:0070412	R-SMAD binding	Zeb2	IDA		Mouse	PMID:16115198
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZEB2	IDA		Human	PMID:20516212
Cellular Component	GO:0000785	chromatin	ZEB2	IDA		Human	PMID:20516212
Cellular Component	GO:0005829	cytosol	ZEB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	ZEB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ZEB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ZEB2	IDA		Human	PMID:24769727
Cellular Component	GO:0005634	nucleus	Zeb2	IDA		Mouse	MGI:MGI:5574413\|PMID:24769727
Cellular Component	GO:0005634	nucleus	Zeb2	IDA		Rat	PMID:30336567\|RGD:155882532
Cellular Component	GO:0005634	nucleus	Zeb2	IDA		Rat	PMID:34852714\|RGD:155882542
Biological Process	GO:0048143	astrocyte activation	Zeb2	IDA		Rat	PMID:34852714\|RGD:155882542
Biological Process	GO:0021846	cell proliferation in forebrain	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2684610	Mouse	PMID:17644613
Biological Process	GO:0007417	central nervous system development	Zeb2	IGI	MGI:MGI:1344313	Mouse	PMID:16598713
Biological Process	GO:0048668	collateral sprouting	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2668659	Mouse	PMID:25741725
Biological Process	GO:0060028	convergent extension involved in axis elongation	zeb2a	IGI	ZFIN:ZDB-MRPHLNO-080717-4,ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0060028	convergent extension involved in axis elongation	zeb2a	IGI	ZFIN:ZDB-MRPHLNO-080717-3,ZFIN:ZDB-MRPHLNO-080717-5	Zfish	PMID:18351671
Biological Process	GO:0060028	convergent extension involved in axis elongation	zeb2b	IMP	ZFIN:ZDB-MRPHLNO-080717-5	Zfish	PMID:18351671
Biological Process	GO:0060028	convergent extension involved in axis elongation	zeb2b	IGI	ZFIN:ZDB-MRPHLNO-080717-3,ZFIN:ZDB-MRPHLNO-080717-5	Zfish	PMID:18351671
Biological Process	GO:0060028	convergent extension involved in axis elongation	zeb2b	IMP	ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0060028	convergent extension involved in axis elongation	zeb2b	IGI	ZFIN:ZDB-MRPHLNO-080717-4,ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0021540	corpus callosum morphogenesis	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2668659	Mouse	PMID:25741725
Biological Process	GO:0021957	corticospinal tract morphogenesis	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2668659	Mouse	PMID:25741725
Biological Process	GO:0048066	developmental pigmentation	Zeb2	IMP		Mouse	MGI:MGI:5574413\|PMID:24769727
Biological Process	GO:0060030	dorsal convergence	zeb2a	IMP	ZFIN:ZDB-MRPHLNO-080717-3	Zfish	PMID:18351671
Biological Process	GO:0060030	dorsal convergence	zeb2a	IGI	ZFIN:ZDB-MRPHLNO-080717-3,ZFIN:ZDB-MRPHLNO-080717-5	Zfish	PMID:18351671
Biological Process	GO:0060030	dorsal convergence	zeb2b	IGI	ZFIN:ZDB-MRPHLNO-080717-3,ZFIN:ZDB-MRPHLNO-080717-5	Zfish	PMID:18351671
Biological Process	GO:0009953	dorsal/ventral pattern formation	zeb2a	IGI	ZFIN:ZDB-MRPHLNO-080717-4,ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0009953	dorsal/ventral pattern formation	zeb2a	IMP	ZFIN:ZDB-MRPHLNO-080717-4	Zfish	PMID:18351671
Biological Process	GO:0009953	dorsal/ventral pattern formation	zeb2b	IMP	ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0009953	dorsal/ventral pattern formation	zeb2b	IGI	ZFIN:ZDB-MRPHLNO-080717-4,ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0048598	embryonic morphogenesis	Zeb2	IGI	MGI:MGI:1344313	Mouse	PMID:16598713
Biological Process	GO:0043542	endothelial cell migration	Zeb2	IMP		Rat	PMID:31881206\|RGD:155882533
Biological Process	GO:0001935	endothelial cell proliferation	Zeb2	IMP		Rat	PMID:31881206\|RGD:155882533
Biological Process	GO:0072537	fibroblast activation	Zeb2	IDA		Rat	PMID:30336567\|RGD:155882532
Biological Process	GO:0090243	fibroblast growth factor receptor signaling pathway involved in somitogenesis	zeb2a	IMP	ZFIN:ZDB-MRPHLNO-100521-9	Zfish	PMID:20034103
Biological Process	GO:0021766	hippocampus development	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2684610	Mouse	PMID:17644613
Biological Process	GO:0035622	intrahepatic bile duct development	zeb2b	IMP	ZFIN:ZDB-MRPHLNO-120222-3	Zfish	PMID:21336163
Biological Process	GO:0035622	intrahepatic bile duct development	zeb2b	IMP	ZFIN:ZDB-MRPHLNO-120222-4	Zfish	PMID:21336163
Biological Process	GO:0061373	mammillary axonal complex development	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2668659	Mouse	PMID:25741725
Biological Process	GO:0097324	melanocyte migration	Zeb2	IMP		Mouse	MGI:MGI:5574413\|PMID:24769727
Biological Process	GO:0036446	myofibroblast differentiation	Zeb2	IEP		Rat	PMID:24155330\|RGD:155882536
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	zeb2a	IMP	ZFIN:ZDB-MRPHLNO-100521-9	Zfish	PMID:20034103
Biological Process	GO:0010764	negative regulation of fibroblast migration	Zeb2	IDA		Rat	PMID:30336567\|RGD:155882532
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ZEB2	IDA		Human	PMID:12837246
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ZEB2	IDA		Human	PMID:20516212
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ZEB2	IMP		Human	PMID:24769727
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Zeb2	IMP		Mouse	MGI:MGI:5574413\|PMID:24769727
Biological Process	GO:0001755	neural crest cell migration	Zeb2	IMP	MGI:MGI:2387501	Mouse	PMID:12522767
Biological Process	GO:0001755	neural crest cell migration	zeb2b	IMP	ZFIN:ZDB-MRPHLNO-130618-1	Zfish	PMID:23466526
Biological Process	GO:0014029	neural crest formation	zeb2a	IGI	ZFIN:ZDB-MRPHLNO-080717-4,ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0014029	neural crest formation	zeb2a	IMP	ZFIN:ZDB-MRPHLNO-080717-4	Zfish	PMID:18351671
Biological Process	GO:0014029	neural crest formation	zeb2b	IMP	ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0014029	neural crest formation	zeb2b	IGI	ZFIN:ZDB-MRPHLNO-080717-4,ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0001843	neural tube closure	Zeb2	IMP	MGI:MGI:2387501	Mouse	PMID:16598713
Biological Process	GO:0050772	positive regulation of axonogenesis	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2668659	Mouse	PMID:25741725
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ZEB2	IMP		Human	PMID:30592286
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2684610	Mouse	PMID:17644613
Biological Process	GO:1902748	positive regulation of lens fiber cell differentiation	Zeb2	IMP		Mouse	MGI:MGI:3604916\|PMID:16162653
Biological Process	GO:0045636	positive regulation of melanocyte differentiation	Zeb2	IMP		Mouse	MGI:MGI:5574413\|PMID:24769727
Biological Process	GO:1904330	positive regulation of myofibroblast contraction	Zeb2	IDA		Rat	PMID:30336567\|RGD:155882532
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ZEB2	IMP		Human	PMID:24769727
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zeb2	IMP		Mouse	MGI:MGI:5574413\|PMID:24769727
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2668659	Mouse	PMID:25741725
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ZEB2	IMP		Human	PMID:30592286
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	Zeb2	IMP	MGI:MGI:2387499,MGI:MGI:2684610	Mouse	PMID:17644613
Biological Process	GO:0070269	pyroptosis	Zeb2	IDA		Rat	PMID:34852714\|RGD:155882542
Biological Process	GO:1905603	regulation of blood-brain barrier permeability	Zeb2	IMP		Rat	PMID:34334113\|RGD:155882538
Biological Process	GO:1903056	regulation of melanosome organization	Zeb2	IMP		Mouse	MGI:MGI:5574413\|PMID:24769727
Biological Process	GO:1904520	regulation of myofibroblast cell apoptotic process	Zeb2	IMP		Rat	PMID:34321385\|RGD:155882552
Biological Process	GO:0090649	response to oxygen-glucose deprivation	Zeb2	IMP		Rat	PMID:34321385\|RGD:155882552
Biological Process	GO:0001756	somitogenesis	Zeb2	IMP	MGI:MGI:2387501	Mouse	PMID:16157277
Biological Process	GO:0001756	somitogenesis	Zeb2	IMP	MGI:MGI:2387501	Mouse	PMID:16598713
Biological Process	GO:0001756	somitogenesis	zeb2a	IGI	ZFIN:ZDB-MRPHLNO-080717-3,ZFIN:ZDB-MRPHLNO-080717-5	Zfish	PMID:18351671
Biological Process	GO:0001756	somitogenesis	zeb2a	IGI	ZFIN:ZDB-MRPHLNO-080717-4,ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0001756	somitogenesis	zeb2a	IMP	ZFIN:ZDB-MRPHLNO-080717-4	Zfish	PMID:18351671
Biological Process	GO:0001756	somitogenesis	zeb2b	IGI	ZFIN:ZDB-MRPHLNO-080717-4,ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0001756	somitogenesis	zeb2b	IMP	ZFIN:ZDB-MRPHLNO-080717-6	Zfish	PMID:18351671
Biological Process	GO:0001756	somitogenesis	zeb2b	IGI	ZFIN:ZDB-MRPHLNO-080717-3,ZFIN:ZDB-MRPHLNO-080717-5	Zfish	PMID:18351671
Biological Process	GO:0001756	somitogenesis	zeb2b	IMP	ZFIN:ZDB-MRPHLNO-080717-5	Zfish	PMID:18351671
Biological Process	GO:0043149	stress fiber assembly	Zeb2	IMP		Rat	PMID:31784544\|RGD:155882534

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/15/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.