Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZNF281
  • Mouse genes Zfp281
  • Rat genes Zfp281
  • Zfish genes znf281a,znf281b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zfp281

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ZNF281	IDA		Human	PMID:10448078
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Zfp281	IMP		Mouse	MGI:MGI:5448086|PMID:22988117
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Zfp281	IMP		Mouse	MGI:MGI:5448369|PMID:21915945
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF281	IDA		Human	PMID:10448078
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Zfp281	IMP		Mouse	MGI:MGI:5448369|PMID:21915945
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Zfp281	IMP		Mouse	MGI:MGI:5448086|PMID:22988117
Molecular Function	GO:0005515	protein binding	ZNF281	IPI	UniProtKB:P01106	Human	PMID:17314511
Molecular Function	GO:0005515	protein binding	ZNF281	IPI	UniProtKB:Q06945	Human	PMID:19147588
Molecular Function	GO:0005515	protein binding	ZNF281	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ZNF281	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ZNF281	IPI	UniProtKB:Q96CV9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Zfp281	IPI	UniProtKB:Q80Z64	Mouse	MGI:MGI:4399017|PMID:17093407
Molecular Function	GO:0005515	protein binding	Zfp281	IPI	UniProtKB:Q80Z64	Mouse	MGI:MGI:5532893|PMID:23892456
Molecular Function	GO:0005515	protein binding	Zfp281	IPI	UniProtKB:Q80Z64	Mouse	MGI:MGI:5448369|PMID:21915945
Molecular Function	GO:0005515	protein binding	Zfp281	IPI	UniProtKB:Q80Z64	Mouse	MGI:MGI:5448086|PMID:22988117
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF281	IDA		Human	PMID:10448078
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Zfp281	IDA		Mouse	MGI:MGI:5448086|PMID:22988117
Molecular Function	GO:0043565	sequence-specific DNA binding	ZNF281	IDA		Human	PMID:10405178
Molecular Function	GO:0043565	sequence-specific DNA binding	ZNF281	IDA		Human	PMID:12771217
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ZNF281	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ZNF281	IDA		Human	PMID:10448078
Cellular Component	GO:0005654	nucleoplasm	ZNF281	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ZNF281	IDA		Human	PMID:10448078
Biological Process	GO:0010172	embryonic body morphogenesis	Zfp281	IMP		Mouse	MGI:MGI:5448369|PMID:21915945
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ZNF281	IMP		Human	PMID:10448078
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ZNF281	IDA		Human	PMID:12771217
Biological Process	GO:0010629	negative regulation of gene expression	ZNF281	IMP		Human	PMID:10448078
Biological Process	GO:0010629	negative regulation of gene expression	ZNF281	IDA		Human	PMID:12771217
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ZNF281	IDA		Human	PMID:10448078
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ZNF281	IDA		Human	PMID:10405178
Biological Process	GO:0048863	stem cell differentiation	Zfp281	IMP		Mouse	MGI:MGI:5448369|PMID:21915945
Biological Process	GO:0048863	stem cell differentiation	Zfp281	IMP		Mouse	MGI:MGI:5448086|PMID:22988117

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern