Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZNF423
  • Mouse genes Zfp423
  • Rat genes Zfp423
  • Zfish genes znf423
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zfp423

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Zfp423	IPI	RGD:621664	Rat	PMID:9774661|RGD:704357
Molecular Function	GO:0005515	protein binding	ZNF423	IPI	UniProtKB:P10276	Human	PMID:19345331
Molecular Function	GO:0005515	protein binding	ZNF423	IPI	UniProtKB:O15078	Human	PMID:22863007
Molecular Function	GO:0005515	protein binding	ZNF423	IPI	UniProtKB:P09874	Human	PMID:22863007
Molecular Function	GO:0005515	protein binding	Zfp423	IPI	UniProtKB:Q01705	Mouse	MGI:MGI:4844232|PMID:20547764
Molecular Function	GO:0044877	protein-containing complex binding	Zfp423	IPI	RGD:620953	Rat	PMID:9774661|RGD:704357
Molecular Function	GO:0043565	sequence-specific DNA binding	ZNF423	IMP		Human	PMID:27727273
Molecular Function	GO:0043565	sequence-specific DNA binding	Zfp423	IMP	MGI:MGI:2671784	Mouse	PMID:27727273
Molecular Function	GO:0043565	sequence-specific DNA binding	Zfp423	IDA		Rat	PMID:9774661|RGD:704357
Cellular Component	GO:0005654	nucleoplasm	ZNF423	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ZNF423	IDA		Human	PMID:10660046
Cellular Component	GO:0005634	nucleus	Zfp423	IDA		Mouse	MGI:MGI:4844232|PMID:20547764
Cellular Component	GO:0005634	nucleus	Zfp423	IDA		Mouse	PMID:27727273
Biological Process	GO:0050873	brown fat cell differentiation	Zfp423	IMP		Mouse	MGI:MGI:4439456|PMID:20200519
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation	Zfp423	IMP		Mouse	PMID:27727273
Biological Process	GO:0060271	cilium assembly	Zfp423	IMP	MGI:MGI:2671784	Mouse	PMID:27727273
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Zfp423	IMP		Mouse	MGI:MGI:6101090|PMID:27238639
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ZNF423	IMP		Human	PMID:27727273
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ZNF423	IDA		Human	PMID:10660046
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Zfp423	IMP	MGI:MGI:2671784	Mouse	PMID:27727273
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Zfp423	IDA		Rat	PMID:9151733|RGD:4142794
Biological Process	GO:0007219	Notch signaling pathway	Zfp423	IDA		Mouse	MGI:MGI:4844232|PMID:20547764
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Zfp423	IDA		Mouse	MGI:MGI:4844232|PMID:20547764
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ZNF423	IDA		Human	PMID:10660046
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Zfp423	IMP		Mouse	MGI:MGI:4844232|PMID:20547764
Biological Process	GO:0061512	protein localization to cilium	ZNF423	IGI	MGI:MGI:1329045	Human	PMID:27727273
Biological Process	GO:0061512	protein localization to cilium	ZNF423	IMP		Human	PMID:27727273
Biological Process	GO:0061512	protein localization to cilium	Zfp423	IMP	MGI:MGI:2671784	Mouse	PMID:27727273
Biological Process	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	Zfp423	IMP		Mouse	PMID:27727273
Biological Process	GO:0050872	white fat cell differentiation	Zfp423	IMP		Mouse	MGI:MGI:4439456|PMID:20200519

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern