Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZIC1
  • Mouse genes Zic1
  • Rat genes Zic1
  • Zfish genes zic1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zic1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Zic1	IDA		Mouse	MGI:MGI:4942260|PMID:11053430
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Zic1	IDA		Mouse	MGI:MGI:4942260|PMID:11053430
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Zic1	IDA		Mouse	MGI:MGI:3056015|PMID:15465018
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:A0PJW8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:A1KXE4-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:O43186	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:O43482	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:O60806	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:O75593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:P35250-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:P59990	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q03989	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q13077	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q13485	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q15654	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q3LHN2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q3LI59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q3LI64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q3LI72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q3LI76	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q3SYF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q496A3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q52LG2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q53HC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q53HV7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q5TA45	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q6NVU6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q6NVV7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q6S9Z5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q6ZNG0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q86WV8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q86XJ1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q8IUB9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q8IUC1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q8IUC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q8IUC3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q8N6F8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q8NFV4-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q8NI38	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q8TDS5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q93062-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q96AZ1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q96N21	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q96RK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q99732	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q99932-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9BVN2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9BYR7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9H2G9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9H5F2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9H7B4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9HBE1-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9HDD0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9NR55	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9NRY6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9NXR5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9NZC7-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9UBV8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9ULX6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9UMX1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9Y5V3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ZIC1	IPI	UniProtKB:Q9Y6H3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Zic1	IPI	UniProtKB:P08151|UniProtKB:P10071|UniProtKB:Q0VGT2	Mouse	MGI:MGI:3688043|PMID:11238441
Molecular Function	GO:0005515	protein binding	Zic1	IPI	UniProtKB:Q8BX65	Mouse	MGI:MGI:4943413|PMID:15207726
Molecular Function	GO:0005515	protein binding	Zic1	IPI	UniProtKB:P08151|UniProtKB:P10071|UniProtKB:Q8K0K3	Mouse	MGI:MGI:3688043|PMID:11238441
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Zic1	IDA		Mouse	MGI:MGI:4942260|PMID:11053430
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Zic1	IDA		Mouse	PMID:18298960
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ZIC1	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Zic1	IDA		Mouse	MGI:MGI:4943413|PMID:15207726
Cellular Component	GO:0005654	nucleoplasm	ZIC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ZIC1	IDA		Human	PMID:8542595
Cellular Component	GO:0005634	nucleus	Zic1	IDA		Mouse	MGI:MGI:3688043|PMID:11238441
Cellular Component	GO:0005634	nucleus	Zic1	IDA		Mouse	MGI:MGI:4943413|PMID:15207726
Biological Process	GO:0007628	adult walking behavior	Zic1	IMP	MGI:MGI:2156822	Mouse	PMID:9412507
Biological Process	GO:0007420	brain development	ZIC1	IDA		Human	PMID:8542595
Biological Process	GO:0007420	brain development	Zic1	IDA		Mouse	MGI:MGI:78770|PMID:7931345
Biological Process	GO:0007420	brain development	zic1	IEP		Zfish	PMID:9778500
Biological Process	GO:0007049	cell cycle	Zic1	IGI	MGI:MGI:106676	Mouse	PMID:17507568
Biological Process	GO:0021534	cell proliferation in hindbrain	zic1	IGI	ZFIN:ZDB-MRPHLNO-080514-2,ZFIN:ZDB-MRPHLNO-080514-3,ZFIN:ZDB-MRPHLNO-080514-6	Zfish	PMID:18191121
Biological Process	GO:0007417	central nervous system development	Zic1	IGI	MGI:MGI:106679	Mouse	PMID:11756505
Biological Process	GO:0007417	central nervous system development	Zic1	IMP	MGI:MGI:2156822	Mouse	PMID:9412507
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	zic1	IMP	ZFIN:ZDB-MRPHLNO-091102-1	Zfish	PMID:19528322
Biological Process	GO:0030900	forebrain development	Zic1	IGI	MGI:MGI:106676	Mouse	PMID:17507568
Biological Process	GO:0048853	forebrain morphogenesis	zic1	IMP	ZFIN:ZDB-MRPHLNO-091102-1	Zfish	PMID:19528322
Biological Process	GO:0021592	fourth ventricle development	zic1	IMP	ZFIN:ZDB-MRPHLNO-080514-4	Zfish	PMID:18191121
Biological Process	GO:0021592	fourth ventricle development	zic1	IMP	ZFIN:ZDB-MRPHLNO-080514-3	Zfish	PMID:18191121
Biological Process	GO:0021592	fourth ventricle development	zic1	IMP	ZFIN:ZDB-MRPHLNO-080514-2	Zfish	PMID:18191121
Biological Process	GO:0010467	gene expression	Zic1	IDA		Mouse	PMID:21211521
Biological Process	GO:0030902	hindbrain development	zic1	IMP	ZFIN:ZDB-MRPHLNO-080514-2	Zfish	PMID:18191121
Biological Process	GO:0030902	hindbrain development	zic1	IMP	ZFIN:ZDB-MRPHLNO-080514-3	Zfish	PMID:18191121
Biological Process	GO:0030902	hindbrain development	zic1	IMP	ZFIN:ZDB-MRPHLNO-080514-4	Zfish	PMID:18191121
Biological Process	GO:0021766	hippocampus development	Zic1	IGI	MGI:MGI:106676	Mouse	PMID:17507568
Biological Process	GO:0098727	maintenance of cell number	Zic1	IGI	MGI:MGI:106676	Mouse	PMID:17507568
Biological Process	GO:0021772	olfactory bulb development	Zic1	IGI	MGI:MGI:106676	Mouse	PMID:17507568
Biological Process	GO:0007389	pattern specification process	Zic1	IDA		Mouse	MGI:MGI:85935|PMID:9070329
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Zic1	IDA		Mouse	MGI:MGI:3056015|PMID:15465018
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Zic1	IDA		Mouse	MGI:MGI:3688043|PMID:11238441
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Zic1	IDA		Mouse	MGI:MGI:4942260|PMID:11053430
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Zic1	IDA		Mouse	MGI:MGI:3688043|PMID:11238441
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zic1	IDA		Mouse	MGI:MGI:4942260|PMID:11053430
Biological Process	GO:0008589	regulation of smoothened signaling pathway	Zic1	IPI	UniProtKB:P47806	Mouse	MGI:MGI:3688043|PMID:11238441
Biological Process	GO:0021510	spinal cord development	Zic1	IMP		Mouse	MGI:MGI:2178698|PMID:11944941

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern