Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZIC3
  • Mouse genes Zic3
  • Rat genes Zic3
  • Zfish genes zic3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zic3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ZIC3	IDA		Human	PMID:17764085
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Zic3	IDA		Mouse	MGI:MGI:4942260|PMID:11053430
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ZIC3	IDA		Human	PMID:17764085
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Zic3	IDA		Mouse	MGI:MGI:4942260|PMID:11053430
Molecular Function	GO:0005515	protein binding	ZIC3	IPI	UniProtKB:P10071	Human	PMID:17764085
Molecular Function	GO:0005515	protein binding	ZIC3	IPI	UniProtKB:O35345	Human	PMID:18716025
Molecular Function	GO:0005515	protein binding	ZIC3	IPI	UniProtKB:Q60960	Human	PMID:18716025
Molecular Function	GO:0005515	protein binding	Zic3	IPI	UniProtKB:Q8BX65	Mouse	MGI:MGI:4943413|PMID:15207726
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZIC3	IDA		Human	PMID:17764085
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Zic3	IDA		Mouse	MGI:MGI:4942260|PMID:11053430
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Zic3	IDA		Mouse	PMID:18298960
Molecular Function	GO:0043565	sequence-specific DNA binding	ZIC3	IDA		Human	PMID:17764085
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ZIC3	IDA		Human	PMID:28473536
Molecular Function	GO:0003713	transcription coactivator activity	Zic3	IMP	MGI:MGI:3698161	Mouse	PMID:17468179
Cellular Component	GO:0005737	cytoplasm	Zic3	IDA		Mouse	MGI:MGI:4943413|PMID:15207726
Cellular Component	GO:0005654	nucleoplasm	ZIC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Zic3	IDA		Mouse	MGI:MGI:3688043|PMID:11238441
Cellular Component	GO:0005634	nucleus	Zic3	IDA		Mouse	MGI:MGI:4943413|PMID:15207726
Biological Process	GO:0009948	anterior/posterior axis specification	zic3	IMP	ZFIN:ZDB-MRPHLNO-120322-1	Zfish	PMID:22285814
Biological Process	GO:0009952	anterior/posterior pattern specification	Zic3	IGI	MGI:MGI:97359	Mouse	PMID:16496285
Biological Process	GO:0009952	anterior/posterior pattern specification	zic3	IEP		Zfish	PMID:11748837
Biological Process	GO:0003228	atrial cardiac muscle tissue development	Zic3	IMP	MGI:MGI:3698161	Mouse	PMID:17468179
Biological Process	GO:0048318	axial mesoderm development	Zic3	IGI	MGI:MGI:106679	Mouse	PMID:17490632
Biological Process	GO:0007049	cell cycle	Zic3	IGI	MGI:MGI:106683	Mouse	PMID:17507568
Biological Process	GO:0035283	central nervous system segmentation	Zic3	IGI	MGI:MGI:106679	Mouse	PMID:17490632
Biological Process	GO:1904888	cranial skeletal system development	Zic3	IMP	MGI:MGI:3698161	Mouse	PMID:17127413
Biological Process	GO:0071907	determination of digestive tract left/right asymmetry	ZIC3	IMP		Human	PMID:9354794
Biological Process	GO:0035545	determination of left/right asymmetry in nervous system	Zic3	IMP		Mouse	MGI:MGI:2178095|PMID:11959836
Biological Process	GO:0007368	determination of left/right symmetry	ZIC3	IMP		Human	PMID:9354794
Biological Process	GO:0007368	determination of left/right symmetry	Zic3	IMP	MGI:MGI:3043027	Mouse	PMID:15384171
Biological Process	GO:0007368	determination of left/right symmetry	Zic3	IGI	MGI:MGI:97359	Mouse	PMID:16496285
Biological Process	GO:0007368	determination of left/right symmetry	Zic3	IMP	MGI:MGI:2180720	Mouse	PMID:16496285
Biological Process	GO:0007368	determination of left/right symmetry	zic3	IMP	ZFIN:ZDB-MRPHLNO-120322-1	Zfish	PMID:22285814
Biological Process	GO:0071910	determination of liver left/right asymmetry	ZIC3	IMP		Human	PMID:9354794
Biological Process	GO:0035469	determination of pancreatic left/right asymmetry	ZIC3	IMP		Human	PMID:9354794
Biological Process	GO:0009880	embryonic pattern specification	Zic3	IMP	MGI:MGI:2180720	Mouse	PMID:16397896
Biological Process	GO:0060324	face development	Zic3	IMP	MGI:MGI:3698161	Mouse	PMID:17127413
Biological Process	GO:0030900	forebrain development	Zic3	IGI	MGI:MGI:106683	Mouse	PMID:17507568
Biological Process	GO:0007369	gastrulation	Zic3	IMP	MGI:MGI:2180720	Mouse	PMID:16397896
Biological Process	GO:0010467	gene expression	Zic3	IGI	MGI:MGI:106679	Mouse	PMID:17490632
Biological Process	GO:0010467	gene expression	Zic3	IMP	MGI:MGI:3698161	Mouse	PMID:17468179
Biological Process	GO:0010467	gene expression	Zic3	IMP		Mouse	PMID:17267691
Biological Process	GO:0010467	gene expression	Zic3	IMP		Mouse	PMID:23184148
Biological Process	GO:0030718	germ-line stem cell population maintenance	Zic3	IMP		Mouse	PMID:32868762
Biological Process	GO:0007507	heart development	Zic3	IMP	MGI:MGI:3698161	Mouse	PMID:17127413
Biological Process	GO:0007507	heart development	Zic3	IMP	MGI:MGI:5476827	Mouse	PMID:23303524
Biological Process	GO:0007507	heart development	Zic3	IMP		Mouse	PMID:23184148
Biological Process	GO:0001947	heart looping	ZIC3	IMP		Human	PMID:9354794
Biological Process	GO:0001947	heart looping	Zic3	IMP	MGI:MGI:2180720	Mouse	PMID:16496285
Biological Process	GO:0001947	heart looping	Zic3	IGI	MGI:MGI:97359	Mouse	PMID:16496285
Biological Process	GO:0001947	heart looping	Zic3	IMP	MGI:MGI:3043027	Mouse	PMID:15384171
Biological Process	GO:0021766	hippocampus development	Zic3	IGI	MGI:MGI:106683	Mouse	PMID:17507568
Biological Process	GO:0070986	left/right axis specification	Zic3	IMP	MGI:MGI:3698161	Mouse	PMID:17127413
Biological Process	GO:0060972	left/right pattern formation	Zic3	IMP	MGI:MGI:5476827	Mouse	PMID:23303524
Biological Process	GO:0060972	left/right pattern formation	Zic3	IMP		Mouse	PMID:23184148
Biological Process	GO:0035108	limb morphogenesis	Zic3	IGI	MGI:MGI:95729	Mouse	PMID:22234993
Biological Process	GO:0030324	lung development	ZIC3	IMP		Human	PMID:9354794
Biological Process	GO:0098727	maintenance of cell number	Zic3	IGI	MGI:MGI:106683	Mouse	PMID:17507568
Biological Process	GO:0007498	mesoderm development	Zic3	IMP	MGI:MGI:2180720	Mouse	PMID:16397896
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	Zic3	IMP		Mouse	PMID:32868762
Biological Process	GO:0001840	neural plate development	Zic3	IGI	MGI:MGI:106679	Mouse	PMID:17490632
Biological Process	GO:0030182	neuron differentiation	Zic3	IMP		Mouse	PMID:17507568
Biological Process	GO:0021772	olfactory bulb development	Zic3	IDA		Mouse	PMID:28814342
Biological Process	GO:0021772	olfactory bulb development	Zic3	IGI	MGI:MGI:106683	Mouse	PMID:17507568
Biological Process	GO:0042473	outer ear morphogenesis	Zic3	IMP	MGI:MGI:3698161	Mouse	PMID:17127413
Biological Process	GO:0048339	paraxial mesoderm development	Zic3	IGI	MGI:MGI:106679	Mouse	PMID:17490632
Biological Process	GO:0007389	pattern specification process	Zic3	IMP	MGI:MGI:2180720	Mouse	PMID:11959836
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Zic3	IDA		Mouse	MGI:MGI:4942260|PMID:11053430
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ZIC3	IDA		Human	PMID:17764085
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zic3	IDA		Mouse	MGI:MGI:4942260|PMID:11053430
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Zic3	IDA		Mouse	PMID:16496285
Biological Process	GO:0090009	primitive streak formation	Zic3	IMP	MGI:MGI:2180720	Mouse	PMID:16397896
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	Zic3	IMP	MGI:MGI:2180720	Mouse	PMID:22234993
Biological Process	GO:0001501	skeletal system development	Zic3	IMP	MGI:MGI:3698161	Mouse	PMID:17127413
Biological Process	GO:0007224	smoothened signaling pathway	Zic3	IGI	MGI:MGI:95729	Mouse	PMID:22234993
Biological Process	GO:0048863	stem cell differentiation	Zic3	IDA		Mouse	PMID:17267691
Biological Process	GO:0019827	stem cell population maintenance	Zic3	IMP		Mouse	PMID:17267691

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern