Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZNRF3
  • Mouse genes Znrf3
  • Rat genes
  • Zfish genes kremen1,znrf3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Znrf3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	ZNRF3	IPI	UniProtKB:O60353	Human	PMID:22575959
Molecular Function	GO:0005109	frizzled binding	ZNRF3	IPI	UniProtKB:Q13467	Human	PMID:22575959
Molecular Function	GO:0005109	frizzled binding	ZNRF3	IPI	UniProtKB:Q9H461	Human	PMID:22575959
Molecular Function	GO:0005109	frizzled binding	ZNRF3	IPI	UniProtKB:Q9ULV1	Human	PMID:22575959
Molecular Function	GO:0005515	protein binding	ZNRF3	IPI	UniProtKB:O60353	Human	PMID:22575959
Molecular Function	GO:0005515	protein binding	ZNRF3	IPI	UniProtKB:O75581	Human	PMID:22575959
Molecular Function	GO:0005515	protein binding	ZNRF3	IPI	UniProtKB:Q2MKA7	Human	PMID:22575959
Molecular Function	GO:0005515	protein binding	ZNRF3	IPI	UniProtKB:Q9BXB1	Human	PMID:22575959
Molecular Function	GO:0005515	protein binding	ZNRF3	IPI	UniProtKB:Q2MKA7	Human	PMID:24165923
Molecular Function	GO:0005515	protein binding	ZNRF3	IPI	UniProtKB:Q6UXX9	Human	PMID:29769720
Molecular Function	GO:0005515	protein binding	ZNRF3	IPI	UniProtKB:Q6UX01	Human	PMID:31073040
Molecular Function	GO:0005515	protein binding	ZNRF3	IPI	UniProtKB:Q5BVD1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Znrf3	IPI	UniProtKB:Q2MKA7	Mouse	MGI:MGI:6414718|PMID:24349440
Molecular Function	GO:0005515	protein binding	Znrf3	IPI	UniProtKB:Q9D1E5	Mouse	MGI:MGI:6303730|PMID:31073040
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ZNRF3	IDA		Human	PMID:22575959
Cellular Component	GO:0005886	plasma membrane	ZNRF3	IDA		Human	PMID:22575959
Biological Process	GO:0001525	angiogenesis	kremen1	IGI	ZFIN:ZDB-MRPHLNO-111104-11,ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:22007135
Biological Process	GO:0048903	anterior lateral line neuromast hair cell differentiation	kremen1	IMP	ZFIN:ZDB-GENO-161220-12	Zfish	PMID:27550540
Biological Process	GO:0001889	liver development	kremen1	IGI	ZFIN:ZDB-GENE-040426-2209	Zfish	PMID:23484855
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ZNRF3	IMP		Human	PMID:22575959
Biological Process	GO:2000051	negative regulation of non-canonical Wnt signaling pathway	ZNRF3	IMP		Human	PMID:22575959
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Znrf3	IMP		Mouse	MGI:MGI:5433224|PMID:22895187
Biological Process	GO:0048884	neuromast development	kremen1	IMP	ZFIN:ZDB-MRPHLNO-131119-10	Zfish	PMID:23891113
Biological Process	GO:0048916	posterior lateral line development	kremen1	IMP	ZFIN:ZDB-GENO-141113-8	Zfish	PMID:25038040
Biological Process	GO:0016567	protein ubiquitination	ZNRF3	IDA		Human	PMID:22575959
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	Znrf3	IMP		Mouse	MGI:MGI:5424263|PMID:22575959
Biological Process	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway	Znrf3	IMP		Mouse	MGI:MGI:5424263|PMID:22575959
Biological Process	GO:0072089	stem cell proliferation	Znrf3	IMP		Mouse	MGI:MGI:5433224|PMID:22895187
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ZNRF3	IMP		Human	PMID:22575959
Biological Process	GO:0038018	Wnt receptor catabolic process	ZNRF3	IMP		Human	PMID:22575959

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern