Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZP3
  • Mouse genes Zp3
  • Rat genes Zp3
  • Zfish genes zgc:173556,zp3.2,zp3a.1,zp3a.2,zp3b,zp3e
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zp3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032190	acrosin binding	ZP3	IPI	UniProtKB:P10323	Human	PMID:15950651
Molecular Function	GO:0030246	carbohydrate binding	ZP3	IDA		Human	PMID:19246320
Molecular Function	GO:0005201	extracellular matrix structural constituent	ZP3	HDA		Human	PMID:28344315
Molecular Function	GO:0042802	identical protein binding	ZP3	IPI	UniProtKB:P21754	Human	PMID:26879157
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:P10323	Human	PMID:15950651
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:O14917	Human	PMID:19945174
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:Q14157	Human	PMID:19945174
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:Q8IXA5	Human	PMID:19945174
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:Q8N349	Human	PMID:19945174
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:Q8N3F8	Human	PMID:19945174
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:Q9Y3D3	Human	PMID:19945174
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:P04406	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:P06733	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:P14618-3	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:P21266	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:P36969	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:P45880	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:P45880-3	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:P60174	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:Q2M2E3	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:Q5BJF6	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:Q96PU9	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ZP3	IPI	UniProtKB:P60852|UniProtKB:Q05996	Human	PMID:28886344
Molecular Function	GO:0005515	protein binding	Zp3	IPI	UniProtKB:Q60736	Mouse	MGI:MGI:4942258|PMID:11417900
Molecular Function	GO:0005515	protein binding	Zp3	IPI	PR:Q60736	Mouse	PMID:7604284
Molecular Function	GO:0005515	protein binding	Zp3	IPI	PR:P15535	Mouse	PMID:8089187
Molecular Function	GO:0005515	protein binding	Zp3	IPI	PR:P23578	Mouse	PMID:11739644
Molecular Function	GO:0005515	protein binding	Zp3	IPI	PR:P15535	Mouse	PMID:9374408
Molecular Function	GO:0048018	receptor ligand activity	Zp3	IMP		Mouse	MGI:MGI:4943398|PMID:17258189
Molecular Function	GO:0048018	receptor ligand activity	Zp3	IDA		Mouse	MGI:MGI:4942264|PMID:10793136
Molecular Function	GO:0035804	structural constituent of egg coat	Zp3	IMP		Mouse	MGI:MGI:2682187|PMID:14645511
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ZP3	IDA		Human	PMID:19246320
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ZP3	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Zp3	IDA		Mouse	MGI:MGI:2177349|PMID:11906903
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Zp3	IDA		Mouse	MGI:MGI:4943662|PMID:19052627
Cellular Component	GO:0035805	egg coat	ZP3	IDA		Human	PMID:29895852
Cellular Component	GO:0005615	extracellular space	ZP3	IMP		Human	PMID:19246320
Cellular Component	GO:0005886	plasma membrane	Zp3	IDA		Mouse	MGI:MGI:2682187|PMID:14645511
Cellular Component	GO:0005886	plasma membrane	Zp3	IDA		Mouse	MGI:MGI:4942258|PMID:11417900
Cellular Component	GO:0005886	plasma membrane	Zp3	IDA		Mouse	MGI:MGI:4943662|PMID:19052627
Biological Process	GO:0007339	binding of sperm to zona pellucida	ZP3	IMP		Human	PMID:19004505
Biological Process	GO:0007339	binding of sperm to zona pellucida	ZP3	IDA		Human	PMID:19246320
Biological Process	GO:0007339	binding of sperm to zona pellucida	ZP3	IDA		Human	PMID:19700799
Biological Process	GO:0007339	binding of sperm to zona pellucida	ZP3	IGI	UniProtKB:P10761	Human	PMID:9609824
Biological Process	GO:0007339	binding of sperm to zona pellucida	Zp3	IMP		Mouse	MGI:MGI:4942258|PMID:11417900
Biological Process	GO:0007339	binding of sperm to zona pellucida	Zp3	IGI	UniProtKB:P21754	Mouse	MGI:MGI:2181829|PMID:9609824
Biological Process	GO:0007339	binding of sperm to zona pellucida	Zp3	IPI	PR:P15535	Mouse	PMID:9374408
Biological Process	GO:0007339	binding of sperm to zona pellucida	Zp3	IDA		Mouse	PMID:11739644
Biological Process	GO:0001825	blastocyst formation	Zp3	IMP		Mouse	MGI:MGI:4943828|PMID:20382503
Biological Process	GO:0035803	egg coat formation	Zp3	IMP		Mouse	MGI:MGI:4943385|PMID:18420282
Biological Process	GO:0035803	egg coat formation	Zp3	IMP		Mouse	MGI:MGI:2682187|PMID:14645511
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	Zp3	IDA		Mouse	MGI:MGI:4943828|PMID:20382503
Biological Process	GO:2000360	negative regulation of binding of sperm to zona pellucida	ZP3	IDA		Human	PMID:18667750
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Zp3	IDA		Mouse	MGI:MGI:4943379|PMID:18667753
Biological Process	GO:0048599	oocyte development	Zp3	IMP		Mouse	MGI:MGI:4943385|PMID:18420282
Biological Process	GO:2000368	positive regulation of acrosomal vesicle exocytosis	ZP3	IMP		Human	PMID:19004505
Biological Process	GO:2000368	positive regulation of acrosomal vesicle exocytosis	ZP3	IDA		Human	PMID:19246320
Biological Process	GO:2000344	positive regulation of acrosome reaction	ZP3	IDA		Human	PMID:11751269
Biological Process	GO:2000344	positive regulation of acrosome reaction	ZP3	IDA		Human	PMID:18667750
Biological Process	GO:2000344	positive regulation of acrosome reaction	ZP3	IDA		Human	PMID:20394732
Biological Process	GO:2000344	positive regulation of acrosome reaction	Zp3	IDA		Mouse	MGI:MGI:4942264|PMID:10793136
Biological Process	GO:2000388	positive regulation of antral ovarian follicle growth	Zp3	IMP		Mouse	MGI:MGI:4943385|PMID:18420282
Biological Process	GO:2000388	positive regulation of antral ovarian follicle growth	Zp3	IMP		Mouse	MGI:MGI:4943828|PMID:20382503
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Zp3	IDA		Mouse	MGI:MGI:4943379|PMID:18667753
Biological Process	GO:0002922	positive regulation of humoral immune response	ZP3	IDA		Human	PMID:19004505
Biological Process	GO:0050729	positive regulation of inflammatory response	Zp3	IDA		Mouse	MGI:MGI:4943379|PMID:18667753
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Zp3	IDA		Mouse	MGI:MGI:4943411|PMID:15579591
Biological Process	GO:0002687	positive regulation of leukocyte migration	Zp3	IDA		Mouse	MGI:MGI:4943379|PMID:18667753
Biological Process	GO:2000386	positive regulation of ovarian follicle development	Zp3	IDA		Mouse	MGI:MGI:4943379|PMID:18667753
Biological Process	GO:2000386	positive regulation of ovarian follicle development	Zp3	IMP		Mouse	MGI:MGI:4943411|PMID:15579591
Biological Process	GO:0042102	positive regulation of T cell proliferation	Zp3	IDA		Mouse	MGI:MGI:4943411|PMID:15579591
Biological Process	GO:0032729	positive regulation of type II interferon production	Zp3	IDA		Mouse	MGI:MGI:4943411|PMID:15579591
Biological Process	GO:0001809	positive regulation of type IV hypersensitivity	Zp3	IDA		Mouse	MGI:MGI:4943411|PMID:15579591
Biological Process	GO:0010469	regulation of signaling receptor activity	Zp3	IMP		Mouse	MGI:MGI:4943398|PMID:17258189
Biological Process	GO:0010469	regulation of signaling receptor activity	Zp3	IDA		Mouse	MGI:MGI:4942264|PMID:10793136

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern