Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	FBN1	HGNC:3603 (HGNC) 2200 (Entrez Gene) 134797 (OMIM) FBN1 (Alliance of Genome Resources)	Chr15 q21.1	Chr15:48408313-48645721 (-) GRCh38	acromicric dysplasia aortic aneurysm autosomal dominant isolated ectopia lentis 1 CREST syndrome geleophysic dysplasia 2 Marfan syndrome mitral valve prolapse mixed connective tissue disease scoliosis stiff skin syndrome systemic scleroderma Weill-Marchesani syndrome	P35555 (UniProt | EBI) NM_001406716 (RefSeq)
mouse	Fbn1	MGI:95489 (MGI) 14118 (Entrez Gene) Gene Tree Fbn1 (Alliance of Genome Resources)	Chr2 61.38 cM	Chr2:125142514-125348417 (-) GRCm39	heart disease Marfan syndrome systemic scleroderma Weill-Marchesani syndrome	14118 (NCBI Gene Model) Q61554 (UniProt | EBI) NM_007993 (RefSeq)
rat	Fbn1	RGD:620908 (Rat Genome Database) 83727 (Entrez Gene) Fbn1 (Alliance of Genome Resources)	Chr3 q36			NP_114013 (RefSeq) NM_031825 (RefSeq)
zebrafish	fbn1	ZDB-GENE-091204-466 (Zebrafish Model Organism Database) 100330961 (Entrez Gene) fbn1 (Alliance of Genome Resources)	Chr18			XP_017207479 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.