Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	CASP8	HGNC:1509 (HGNC) 841 (Entrez Gene) 601763 (OMIM) CASP8 (Alliance of Genome Resources)	Chr2 q33.1	Chr2:201233443-201361836 (+) GRCh38	autoimmune lymphoproliferative syndrome type 2B breast cancer esophagus adenocarcinoma hepatocellular carcinoma lung cancer pancreatic cancer primary immunodeficiency disease	Q14790 (UniProt | EBI) NM_001400679 (RefSeq)
mouse	Casp8	MGI:1261423 (MGI) 12370 (Entrez Gene) Gene Tree Casp8 (Alliance of Genome Resources)	Chr1 29.19 cM	Chr1:58834533-58886662 (+) GRCm39	atopic dermatitis autoimmune lymphoproliferative syndrome type 2B	ENSMUSG00000026029 (Ensembl Gene Model) ENSMUSP00000140546 (Ensembl) ENSMUST00000191201 (Ensembl)
rat	Casp8	RGD:620945 (Rat Genome Database) 64044 (Entrez Gene) Casp8 (Alliance of Genome Resources)	Chr9 q31			Q9JHX4 (UniProt | EBI) NM_022277 (RefSeq)
zebrafish	casp8	ZDB-GENE-000713-1 (Zebrafish Model Organism Database) 58022 (Entrez Gene) casp8 (Alliance of Genome Resources)	Chr6			NP_571585 (RefSeq) NM_131510 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.