Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	CYP2C8	HGNC:2622 (HGNC) 1558 (Entrez Gene) 601129 (OMIM) CYP2C8 (Alliance of Genome Resources)	Chr10 q23.33	Chr10:95036772-95069497 (-) GRCh38	end stage renal disease renal hypertension	P10632 (UniProt | EBI) NM_001198855 (RefSeq)
	CYP2C9	HGNC:2623 (HGNC) 1559 (Entrez Gene) 601130 (OMIM) CYP2C9 (Alliance of Genome Resources)	Chr10 q23.33	Chr10:94938658-94990091 (+) GRCh38	diabetes mellitus head and neck squamous cell carcinoma hyperglycemia hypertension hypoglycemia type 2 diabetes mellitus urinary bladder cancer warfarin resistance	P11712 (UniProt | EBI) NM_000771 (RefSeq)
	CYP2C18	HGNC:2620 (HGNC) 1562 (Entrez Gene) 601131 (OMIM) CYP2C18 (Alliance of Genome Resources)	Chr10 q23.33	Chr10:94683729-94736190 (+) GRCh38		P33260 (UniProt | EBI) NM_000772 (RefSeq)
	CYP2C19	HGNC:2621 (HGNC) 1557 (Entrez Gene) 124020 (OMIM) CYP2C19 (Alliance of Genome Resources)	Chr10 q23.33	Chr10:94762681-94855547 (+) GRCh38	breast cancer eosinophilic esophagitis head and neck squamous cell carcinoma hepatocellular carcinoma heroin dependence invasive aspergillosis multiple chemical sensitivity multiple myeloma peptic ulcer disease Plasmodium falciparum malaria sickle cell anemia tuberculosis	P33261 (UniProt | EBI) NM_000769 (RefSeq)
mouse	Cyp2c29	MGI:103238 (MGI) 13095 (Entrez Gene) Gene Tree Cyp2c29 (Alliance of Genome Resources)	Chr19 33.91 cM	Chr19:39275541-39319157 (+) GRCm39		13095 (NCBI Gene Model) Q64458 (UniProt | EBI) NM_007815 (RefSeq)
rat	Cyp2c6	RGD:619934 (Rat Genome Database) 293989 (Entrez Gene) Cyp2c6 (Alliance of Genome Resources)	Chr1 q53			P05178 (UniProt | EBI) NM_001013904 (RefSeq)
	Cyp2c7	RGD:620379 (Rat Genome Database) 29298 (Entrez Gene) Cyp2c7 (Alliance of Genome Resources)	Chr1 q53			P05179 (UniProt | EBI) NM_017158 (RefSeq)
zebrafish	cyp2y3	ZDB-GENE-050522-490 (Zebrafish Model Organism Database) 368352 (Entrez Gene) cyp2y3 (Alliance of Genome Resources)	Chr15			NP_001018658 (RefSeq) NM_001020822 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.